5

votes

Do you have the fat gene blues?

Answered on August 19, 2014
Created February 10, 2011 at 11:24 AM

I bought the 23andme DNA service. I sent my spit to the lab a couple of months ago, and my results posted yesterday. Sure enough, I am at super duper high risk for obesity. Looking closer at my data, I find that of all of the well publicized genetic markers for obesity - I have them all, in spades! I couldn't be more predisposed to be fat, fat, fat! I have the ultimate fat code coursing through my body! :: shakes fist at mother for passing these along ::

This explains a lot. On a Paleo diet, if I even look at a carb I gain weight and that insatiable hunger kicks in. I can't even eat leafy greens. Baby, I've tried. I've been following Dr. Harris' blog, and even tried eating those damn Rice Krispies with half-and-half day before yesterday for the hell of it, and walked around the rest of the day wanting to KILL someone, anyone, for their stash of PopTarts and potatoes.

I'm wondering if those of us who must keep on a very low to zero carb diet are those who are carrying around those blasted fat genes.

Anyone else have dna results to share, and how you feel those results explain your response to various Paleo diet issues?

5de2fffda92c0bf2be7ede10cad55546

(1781)

on February 12, 2011
at 01:40 PM

You don't mean skinny blue jeans do you? ;p

691f120a3e7a1a036845d105d86c99a3

(3641)

on February 10, 2011
at 08:36 PM

i find i do best when i avoid carbs altogether--less craving, less chance of derailment. i seem to get gluttened like effects from sugary things and alcohols. i also seem to experience a rise in fat % when i am in the proximity of donuts even though i haven't had one in a very long time. i seem to tolerate the tuber family tho.

Medium avatar

(39831)

on February 10, 2011
at 08:02 PM

What does a typical day's worth of food look like right now?

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on February 10, 2011
at 06:20 PM

the link to that discussion is here "http://robbwolf.com/2011/01/19/nutritional-relativism/" that comment section is rife with great info being traded back and forth by guys like kurt harris, masterjohn and wolf.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on February 10, 2011
at 06:18 PM

Our vast network of transcription factors can regulate genes on a scale of minutes to hours to days, in some cases perhaps weeks or months. Epigenetic modifications can regulate gene expression on this scale and extend it for generations." I'm no scientist but this falls in line with my experiences.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on February 10, 2011
at 06:17 PM

i'm not scientist, but from the bit of reading i've done, gene regulation and the expression of those genes can be affected by outside stimulus. recently on a spirited discussion on a post on robb wolf's site, chris masterjohn said: "The expression of our genes is regulated in response to environmental cues by numerous different mechanisms that range in time span from seconds to generations. For example, phosphorylation and other types of covalent modification of proteins can regulate the activity of proteins coded by our genes on a scale of seconds to minutes in response to the environment.

030e4c293151bf6c70550dcfcfde0f67

(1537)

on February 10, 2011
at 06:07 PM

Hi Mike, like I told luckbastard, I am doing great with VVLC Paleo - I don't have cravings, I feel fantastic, my weight is at a wonderful point. I just can't handle carbs, and I really do believe now, after this testing, that it is my genetics. So my question was for those who have also had the testing, whether they found common ground or something really interesting that has helped them understand their most optimal diet.

030e4c293151bf6c70550dcfcfde0f67

(1537)

on February 10, 2011
at 06:06 PM

It's great that you found what's working for you! I'm not fat at all, I lost 30 pounds when I changed from a "healthy" diet based on all whole foods to a VVLC Paleo diet. I do IF. I exercise. I simply can't handle carbs, and I believe it is my genetic makeup. I don't think it's possible to "reprogram" your genome. That would be like saying I am going to become straight instead of lesbian. ain't gonna happen. Or I am going to reprogram my genes to be a vegan. We are the sum of our genetic code, but we can find out the best pathway that our own codes allow.

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3 Answers

1
66e6b190e62fb3bcf42d4c60801c7bf6

on February 10, 2011
at 05:22 PM

i don't know if i really believe in the fat gene anymore. i've been a heavy kid all my life. (important numbers in my memory- [email protected], [email protected], [email protected], [email protected] then it really got bad) but after high school and during college, i ran and lifted like hell and had a decent composition by exercising twice as much for half the results, but i was fine with that coming where i was when i was younger. i just was going to be in a war of attrition with the fat genes til they finally took me under- hopefully later rather than sooner.

however, after learning more about the science of our bodies while doing paleo, i came across the idea of epigenetics. http://www.marksdailyapple.com/epigenetics/ at first i was skeptical but everything that's happened to me on paleo has made me think that it's indeed possible to reprogram your genes. also, i think the reason many of us haven't been able to handle moderate amounts of low-fructose fruits and starches is because there's still some metabolic derangement there. i spent the first 4-5 months of paleo in the low carb camp. but the last few months after learning more about how insulin sensitivity works with your body when working with tools such as IF and fasted training, i've actually lost weight while consuming several potatoes or sweet potatoes along with a 3-4 pieces of fruit during the week.

to get your insulin sensitivity in line, i would start messing around with some intermittent fasting. I would also start tooling around with some post-workout glucose from either potatoes or sweet potatoes. it'll do wonders for teaching your body how to utilize starches. the further i get into this, the more i realize that good carbohydrates- particularly starches- are not to be something you fear and tubers are as paleo as a nice grass fed steak if you've taken care of insulin sensitivity issues and metabolic syndrome.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on February 10, 2011
at 06:18 PM

Our vast network of transcription factors can regulate genes on a scale of minutes to hours to days, in some cases perhaps weeks or months. Epigenetic modifications can regulate gene expression on this scale and extend it for generations." I'm no scientist but this falls in line with my experiences.

030e4c293151bf6c70550dcfcfde0f67

(1537)

on February 10, 2011
at 06:06 PM

It's great that you found what's working for you! I'm not fat at all, I lost 30 pounds when I changed from a "healthy" diet based on all whole foods to a VVLC Paleo diet. I do IF. I exercise. I simply can't handle carbs, and I believe it is my genetic makeup. I don't think it's possible to "reprogram" your genome. That would be like saying I am going to become straight instead of lesbian. ain't gonna happen. Or I am going to reprogram my genes to be a vegan. We are the sum of our genetic code, but we can find out the best pathway that our own codes allow.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on February 10, 2011
at 06:20 PM

the link to that discussion is here "http://robbwolf.com/2011/01/19/nutritional-relativism/" that comment section is rife with great info being traded back and forth by guys like kurt harris, masterjohn and wolf.

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on February 10, 2011
at 06:17 PM

i'm not scientist, but from the bit of reading i've done, gene regulation and the expression of those genes can be affected by outside stimulus. recently on a spirited discussion on a post on robb wolf's site, chris masterjohn said: "The expression of our genes is regulated in response to environmental cues by numerous different mechanisms that range in time span from seconds to generations. For example, phosphorylation and other types of covalent modification of proteins can regulate the activity of proteins coded by our genes on a scale of seconds to minutes in response to the environment.

0
0ee98c251b5eef357445aefec99c5d7b

(888)

on February 10, 2011
at 07:36 PM

I have skinny gene blues, does that count? ;)

5de2fffda92c0bf2be7ede10cad55546

(1781)

on February 12, 2011
at 01:40 PM

You don't mean skinny blue jeans do you? ;p

0
691f120a3e7a1a036845d105d86c99a3

(3641)

on February 10, 2011
at 05:53 PM

I too have a bunch of fat genes and I've been 'overweight' for most of my adult life but never really obese. I'd blame beer, pizza and candy bar addiction for that though and genetics for making it so hard to get into shape. I think unless you have the "skinny" genes that let you digest sugars and carbs super efficiently, it is just the human genome that predisposes you to getting fat from sugars and grains.

That said, I agree with Luckybastard that it takes time to get the body adjusted after years of abuse. There is also the whole thing about fat cells making us hungry because they steal and store food energy. If you already have fat, you are more predisposed to gaining rather than losing it so it's a tough psychological battle. Luckily, the very nature of the paleo diet can turn off hunger pangs completely if done right and that added with fat burning soon the fat cells wont be able to send out messages to make you hungry and crave sugars. But it takes time to convert.

691f120a3e7a1a036845d105d86c99a3

(3641)

on February 10, 2011
at 08:36 PM

i find i do best when i avoid carbs altogether--less craving, less chance of derailment. i seem to get gluttened like effects from sugary things and alcohols. i also seem to experience a rise in fat % when i am in the proximity of donuts even though i haven't had one in a very long time. i seem to tolerate the tuber family tho.

030e4c293151bf6c70550dcfcfde0f67

(1537)

on February 10, 2011
at 06:07 PM

Hi Mike, like I told luckbastard, I am doing great with VVLC Paleo - I don't have cravings, I feel fantastic, my weight is at a wonderful point. I just can't handle carbs, and I really do believe now, after this testing, that it is my genetics. So my question was for those who have also had the testing, whether they found common ground or something really interesting that has helped them understand their most optimal diet.

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