Cholesterol is converted to Vitamin D in our skin by UVB rays, right? So if we already have higher vitamin D levels from supplementation, our body doesn't need to make more vitamin D, so that dietary cholesterol goes unused. Could this explain why some people have high cholesterol levels? Or is it a different pathway/different type of vitamin D?
asked byjeneane (354)
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on June 14, 2011
at 07:30 PM
You're talking two different pathways that don't interact. Vitamin D in the skin self limits on Vitamin D creation. Supplemented Vitamin D bypasses that. So you're still using the same amount of cholesterol you would be either way. Plus you have a chance of overdosing on Vitamin D over time.
on June 14, 2011
at 04:18 PM
If your D is optimized it will knock your LDL down over 18 months but vit D supplementation increases your LDL short term because of the way it's calculated. Not a huge effect as long as you and the doc know it
on July 25, 2012
at 05:21 PM
I know this is an old thread, but I've had the same thought.
@James: Can you elaborate on the different pathways? From what little I've read, 7-Dehydrocholesterol is used to produce cholesterol as well as vitamin D. So it seems that it might be possible that if more 7-Dehydrocholesterol were converted into vitamin D, it would leave less to be converted into cholesterol. Just a thought I had that might easily be disproven.
I also came across this study abstract: http://www.jlr.org/content/39/3/647.abstract I don't totally understand it, but it mentions that 7-Dehydrocholesterol seems to exhibit an inhibitory effect on cholesterol production by inhibiting HMG-CoA reductase (same mechanism as statins). This study was performed with cells from people with Smith-Lemli-Opitz Symdrome, so it may not apply to the general population. Any biochemists care to chime in?