6

votes

High vitamin D levels bad?

Answered on September 12, 2014
Created September 15, 2011 at 8:41 PM

Per Chris Kresser:

Contrary to what some researchers and doctors have recommended, there???s no evidence that raising blood levels of 25D above 50 ng/mL is beneficial, and there???s some evidence that it may cause harm. Studies show that bone mineral density peaks at 45 ng/mL and then falls again as 25D levels rise above 45. Other studies have shown that the risk of kidney stones and CVD increase with high 25D levels, due to elevated serum calcium levels that accompany excess vitamin D.

Yet, others promote high levels of 25D in excess of 50. Someone else on here recently promoted 25D to be ideal when it's between 70 and 100 ng/mL.

What's the evidence that there are benefits to raising 25D above 50, and what other evidence is there that going beyond 50 is either not beneficial, or outright worse for you?

64433a05384cd9717c1aa6bf7e98b661

(15236)

on September 23, 2011
at 01:07 AM

46. I'm not upset but I'm not thrilled either. I'm going to start supplementing and visiting the tanning beds.

Medium avatar

(39831)

on September 19, 2011
at 03:09 AM

For some weird reason that vitamin d/calcium bun sounds good.

3864f9a2af09b1b447c7963058650a34

(3703)

on September 19, 2011
at 12:19 AM

Rose, Sondra -- I had asthma which vitamin D (+ omega-3/Mag) cleared it i[ but low thyroid and low adrenals/cortisol) are also under-appreciated factors for asthma as well.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 18, 2011
at 04:23 PM

No, majikinetor. After exhaustive reading of the available research, I am not concerned about having a "high" level. Like Rose, I have noticed I need to keep my levels in the high end to avoid any asthma symptoms. I ensure that I get sufficient A, K, and magnesium.

77877f762c40637911396daa19b53094

(78467)

on September 18, 2011
at 03:37 PM

Have you checked for calcification ? That borders with hypervitaminosis (100ng/ml)

77877f762c40637911396daa19b53094

(78467)

on September 18, 2011
at 03:36 PM

Have you checked for calcification ? That borders with hypervitaminosis.

77877f762c40637911396daa19b53094

(78467)

on September 18, 2011
at 03:35 PM

Thats MK4 I presume, MK7 is taken in mcg doses, right ?

3864f9a2af09b1b447c7963058650a34

(3703)

on September 18, 2011
at 06:02 AM

HOLY COW. *haa!!* My sister required high doses for a while (like 20,000/day) but that was before she realized fats were not digesting per a Metametrix GI fx that I ordered on her. We're both on Ness (and NOW and Thorne) digestive lipases and enzymes, and she reports she only takes 4000-5000 IU per day unless sick. Thanks for all of your insights John.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 18, 2011
at 03:54 AM

Oh, and I have a dark complexion, so don't get much from the sun.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 18, 2011
at 03:52 AM

I don't weigh myself anymore, but guessing ~125 lbs. Everyone's different, from what I've seen on the MDA forum. That's why testing every 6 months is a good idea.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 18, 2011
at 02:56 AM

I have a patient who takes 75k a day grace.......has a snp and this is what it takes to keep her at sixty. She lives in Florida and has lost sixty pounds and has 12% BF now.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 18, 2011
at 02:52 AM

Lol....namby I have a few patients with real lod HDL levels from FH who are on 45 mgs of k2 a day......they ar few and far between but their labs dictate what to do.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 18, 2011
at 02:49 AM

Maj.....my C intake is pretty stiff.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 18, 2011
at 01:33 AM

Dragonfly, u mind if I ask what your weight is? My aunt (90 lber) started supplementing only 2000 per day for 3 months and is now at 95. Hard to believe. Me, a 160 lber. did 5000 per day for a year when I reached the mid 90s. D kind of creeps up on you.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 18, 2011
at 01:31 AM

What do you mean by a C megadose? I take 500mg Vit C since I think I'm taking in at least 500mg from food sources.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:57 PM

Quilt, have you tried it in combination with C megadose ? There is synergy for sure. I have not been sick, together with my close friends who practice exactly the same protocol for years.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:53 PM

@Quilt, yes, If I could I would integrate bunch of loggers bellow the skin. I currently generate lots of data and use data mining algorythms to find correlations based on my input/output and that of my environment [I am mathematican]. Medical testing is expensive and I have to use another means to achieve my goals.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:49 PM

@Quilt, yes, I suspect some genetic problem. My syster has low levels after vacation and lots of supplementing and my mother has hypertension. However, genetic testing is out of my price domain for now and things in Serbia aren't quite at latest level. Doctors here looked at me like a lunatic when I said I want D test.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:48 PM

@Namby, 100mcg not mg. Try mixed ones, like that of LEF.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:48 PM

@WyldKard, maybe not anti, but low supplementation regime for sure.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:47 PM

@WyldKard, maybe not anti, but low supplementation regime for sure. @Namby, 100mcg not mg. Try mixed ones, like that of LEF. @Quilt, yes, I suspect some genetic problem. My syster has low levels after vacation and lots of supplementing and my mother has hypertension. However, genetic testing is out of my price domain for now. Doctors here looked at me like a lunatic when I said I want D test.

Da8e709acde269e8b8bfbc09d1737841

(1906)

on September 16, 2011
at 03:11 PM

@majkinetor - Calling Kresser anti-supplementation isn't entirely accurate. The post I linked on his blog in the OP, after all, is about supplements he recommends for some people.

D10ca8d11301c2f4993ac2279ce4b930

(5242)

on September 16, 2011
at 02:57 PM

Over supplementation may cause depletion of other fat soluble vitamins particularly k2. If you're levels aren't rising, it doesn't mean mega dosing is called for.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 16, 2011
at 02:30 PM

Quilt, what's your suggestion for daily Vit K-2 dose? 100mg or higher?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:56 PM

I have had my levels above sixty for close to six yrs. No colds flu or any sickness. It's an n-1 but I found the same to be true of my patients in clinic.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:55 PM

Keep us update Jeff.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:54 PM

Maj read my vitamin D post called sunshine of your life. You might be one of the patients that has a snp or a VDR issue

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:53 PM

Maj you and I both know there is no magic bullet or magic test. Everything is about context and measured on a continuum.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:52 PM

Ultimately patients will decide what works for them. The sicker they are the lower their D's are becoming. As a spine surgeon I see a pretty amazing amount of hypovitaminosis and human disease

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 01:05 PM

I did K2 for few months (50-100mcg K2 MQ7) and 10K mixed A. My PTH Is 3.31 pmol/L [1.5-7.2], CRP 1.3 mg/L [0-10] and HDL is 1.2 [0.9-1.55]. I also did 20-30 min sunshine for 3 months during spring with 30% body exposed.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 01:02 PM

I did K2 for few months (50-100mcg K2 MQ7) and 10K mixed A. My PTH Is 3.31 pmol/L [1.5-7.2], CRP 1.3 mg/L [0-10] and HDL is 1.2 [0.9-1.55].

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 01:00 PM

BTW, small question for you. I never broke a bone and I have crepitus. I was 1 month on sea, returned basically black. I did 50K IU for 2 weeks then 10K for 2 months and 1 year or so constantly fish oil (1-2tbsp and even 2 tsp, but its not liver oil). I eat eggs and butter every day and get some more from multi. My level is 33 after all that stuff.... how can that be.... the only thing that crosses my mind is history of morphea (linear scleroderma).

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 12:57 PM

I agree with you, but keep in mind that fixing up 1 thing isn't magic bullet. You need redundant pathways of recovery. What, if, for example, some pathogen disables conversion of D3 into 1,25D or disables nuclear receptor for that matter. What if your liver for some reason can't 25-hydroxylate vitamin D3. I think that people tend to be preoccupied with single molecules and forgetting that there are other things that matter, while better effects are achieved with synergy of important resources as each can let the body approach the 'problem' from different perspective.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 12:39 PM

As someone who has over ten yrs of experience using vitamin d 3 on humans and seeing them from the outside and more importantly on the inside and assessing their bone .......I know a higher vitamin d and optimal vit k2 are very important.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 09:11 AM

BTW, Chris Kresser is in anti-supplementation camp.

33907fee54e98865a1988e5eef59147e

(480)

on September 16, 2011
at 03:26 AM

please update with a comment when the level comes back

3aea514b680d01bfd7573d74517946a7

(11996)

on September 15, 2011
at 10:04 PM

Yes, for asthma. Sorry to be unclear.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 15, 2011
at 10:03 PM

By inhaler you mean for your asthma?

3aea514b680d01bfd7573d74517946a7

(11996)

on September 15, 2011
at 09:58 PM

Another N=1: My level in June was 78 ng/ml, and at that level I don't use my inhaler -- *ever*. (I've used it nearly daily for over 20 years.) Since my lab work in June, I've tried dropping my supps to about 60% of my former dosage, and the chest tightness came back. So I'm sticking to the high side; it has immediate physical repercussions for me.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 15, 2011
at 09:54 PM

Moved from the Pac NW to Santa Fe, so more chances to get sun. Staying on the higher end due to longstanding inflammation issues that seem to be sorting themselves out. May consider dropping down to 60 ng/ml once I feel I am where I want to be in terms of resilience.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on September 15, 2011
at 09:29 PM

It's not about teams, it's about science and using common sense and caution in absence of perfect knowledge. I'm generally comfortable with the ranges that people were designed to get if they spent all day outside working. That's between about 30 and 55 ng/ml. More than that and you're doing a self-experiment.

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on September 15, 2011
at 09:01 PM

Mine went from 31 to 44 after 2 months of FCLO. Then I dropped CLO and went from 44 to 58 on lots of sun as my only non food source. (no supps in other words). Not sure what to make of it but that's my story.

11838116de44ae449df0563f09bd3d73

(655)

on September 15, 2011
at 08:50 PM

Pick your team: Kresser and Harris on the low end, The Quilt and others on the high end. I'm a wimp shooting for 50ng. There's no strong evidence one way or another, AFAIK. Supplementation and sun exposure are probably not equivalent.

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7 Answers

4
Medium avatar

on September 18, 2011
at 12:00 AM

Vitamin D increases the absorption of dietary Ca (via the CaT1 duodenal epithelial calcium channel) and Mg. http://www.ncbi.nlm.nih.gov/pubmed/477243 (Something to note is that magnesium absorption rises, but so does magnesium excretion). If you couple this with a high-calcium diet (the SAD) and a deficiency in retinol, K-2 etc., you could very well increase your serum calcium levels into the danger range and calcify your soft tissues and eventually cause a heart attack. If you eat a paleo diet, or even if you eat a SAD-level of calcium with dairy/supplements but get enough of the other fat solubles, you'll just build strong bones and teeth.

Something to consider is that most of us (especially the former veg*ns) are coming to paleo with much weaker bones and teeth than we would otherwise have. If you'd like to accelerate the mineralization process, you may want to overshoot for a bit.

That all said, because I don't weigh very much, 5000IU through last winter got me to 85ng/mL. This winter I'm going to take 4000IU/day. I'm also going to split up the dose into smaller parts just in case.

3
3864f9a2af09b1b447c7963058650a34

(3703)

on September 17, 2011
at 11:44 PM

I've been on/off vitamin D since 2008 when dx'd w/ deficiency -- for my whole life I had seasonal affective d/o in the winter with major blues since my teens, bronchitis, mild tinnitus (ears ringing) and RAD asthma. Once on vitamin D, I stopped all inhalers (which were worthless for the most part) and my mood was 200% better in the winters. I found that any level < 60 ng/ml would trigger asthma with a cold, plus more frequent colds. My kids are on D and off inhalers and now rarely get sick as well.

Sunlight -- esp noon time with a run/sprint or long run -- gives me a high just like when I initially supplemented, me but since I am dark-skinned I wonder how much of the melanain actually shuts down the vitamin D conversion in the skin? I suspect a lot is blocked. I was diagnosed w/D deficiency (19 ng/ml) at the end of summer where I was in the sun nearly daily w/my kids in a bikini (with sunscreen but no reapplication and some dips in the water/sweat).

Ancestrally we all evolved in different microniches and exposures to UVA, UVB, UVC, etc. There are SNPs, VDR polymorphisms and rare post-receptor and translational variations. I actually suspect there are also adrenal and thyroidal effects on the liver/kidney and other metabolism changes which effect intracellular 1,25OHD2 concentrations that scientists haven't elucidated. Just like drugs and low thyroid/adrenal slow liver enzymes and P450 pathways and depress the elimination of steroids and certain drugs.

I've only heard of VERY rare side effects (eg one blogger), but for the great majority a combo of ancestrally derived UV radiation/sun exposures, food sources (grub, fatty seafood, livers, animal fat, CLO, mushrooms (D2) etc), cofactors (minerals, vit A/retinoids, carotenoids, mixed tocopherols, mixed menaquinones, etc) and supplementation as needed appears to me to provide the most benefits with least downsides...

In checking out the other extreme -- I tried OD'ing once on high dose A and D (like 20k per day each) and gave myself the same symptoms of D deficiency, namely fat gain, insulin resistance and feeling 'weird' (my ears 'ring' with supra-therapeutic doses or bad deficiency). Didn't know about K2 and the depletion of other fat-soluble nutrients at the time!

To me, labs sometimes (?often) are irrelevant (like TSH without context of rT3, FT4, FT3, antibodies, etc). LIke thyroid panels and magnesium, the intracellular conc is MOST important yet we don't check this with the current $$$ and other limitations.

EDIT: Though I love medical science, the limitations are that they are studies done on poor lab rats (humans) who are probably on the SAD, high fiber, sunlight deficient/indoor, fermented food/K2-deficient. How can we extrapolate bone density when they are not paleo and extremely micro- and macro-nutrient deficient? The contraindication for bioidentical D3 is sarcoidosis, a rare autoimmune condition where errant cells are producing endogenous 25OHD and/or 1,25OHD2 or other vitamin D analogues (like pheochromocytoma where errant cells are producing BP-raising, palpitation inducing adrenaline and/noradrenaline).

3864f9a2af09b1b447c7963058650a34

(3703)

on September 18, 2011
at 06:02 AM

HOLY COW. *haa!!* My sister required high doses for a while (like 20,000/day) but that was before she realized fats were not digesting per a Metametrix GI fx that I ordered on her. We're both on Ness (and NOW and Thorne) digestive lipases and enzymes, and she reports she only takes 4000-5000 IU per day unless sick. Thanks for all of your insights John.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 18, 2011
at 02:56 AM

I have a patient who takes 75k a day grace.......has a snp and this is what it takes to keep her at sixty. She lives in Florida and has lost sixty pounds and has 12% BF now.

3
77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 07:27 AM

There is no proof that every day supplementation of <= 10 000 IU causes calcification on the long run. More might, however. Vitamin K is antidote used with rat poison which basically calcifies the pure creature and your cat. Kidney stones are preventable with ascorbate [stones can't form in acidic environment] and Mg [has higher affinity to oxalates].

There are other functions of Vitamin D apart from bone density - it controls 10% of your genome.

This is generally true for standard medicine - while good in acute things and baby deliveries, it fails to recognize that supplements are needed for more then to prevent deficiencies. Deficiency of any vitamin is the last stage and levels needed for optimal health are far higher. You will not feel the difference ASAP as our body is crazy adaptive machine, but it will substitute with lesser evil [plan B] in absence of resources. For instance, if you are scorbutic it will affect your blood vehicles first and body will deposit LP(a) cholesterol to prevent collagen breaks - the reasoning is its better to die 10 years later because of atherosclerosis then in a month because of internal bleeding [prolonged survival is important as we need to pass our genome and educate-it/protect it but longevity isn't].

I wouldn't be too much concerned about lower levels. My level is 35 and I wasn't seek in 3 years, not a single caugh, except 1 day virus. If you synergies nutrients you need lesser levels of all. If you give all your hopes to D, then you better boost it up.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 12:39 PM

As someone who has over ten yrs of experience using vitamin d 3 on humans and seeing them from the outside and more importantly on the inside and assessing their bone .......I know a higher vitamin d and optimal vit k2 are very important.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 09:11 AM

BTW, Chris Kresser is in anti-supplementation camp.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:53 PM

Maj you and I both know there is no magic bullet or magic test. Everything is about context and measured on a continuum.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:48 PM

@WyldKard, maybe not anti, but low supplementation regime for sure.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:52 PM

Ultimately patients will decide what works for them. The sicker they are the lower their D's are becoming. As a spine surgeon I see a pretty amazing amount of hypovitaminosis and human disease

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:53 PM

@Quilt, yes, If I could I would integrate bunch of loggers bellow the skin. I currently generate lots of data and use data mining algorythms to find correlations based on my input/output and that of my environment [I am mathematican]. Medical testing is expensive and I have to use another means to achieve my goals.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 12:57 PM

I agree with you, but keep in mind that fixing up 1 thing isn't magic bullet. You need redundant pathways of recovery. What, if, for example, some pathogen disables conversion of D3 into 1,25D or disables nuclear receptor for that matter. What if your liver for some reason can't 25-hydroxylate vitamin D3. I think that people tend to be preoccupied with single molecules and forgetting that there are other things that matter, while better effects are achieved with synergy of important resources as each can let the body approach the 'problem' from different perspective.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 16, 2011
at 02:30 PM

Quilt, what's your suggestion for daily Vit K-2 dose? 100mg or higher?

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 01:05 PM

I did K2 for few months (50-100mcg K2 MQ7) and 10K mixed A. My PTH Is 3.31 pmol/L [1.5-7.2], CRP 1.3 mg/L [0-10] and HDL is 1.2 [0.9-1.55]. I also did 20-30 min sunshine for 3 months during spring with 30% body exposed.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:54 PM

Maj read my vitamin D post called sunshine of your life. You might be one of the patients that has a snp or a VDR issue

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:47 PM

@WyldKard, maybe not anti, but low supplementation regime for sure. @Namby, 100mcg not mg. Try mixed ones, like that of LEF. @Quilt, yes, I suspect some genetic problem. My syster has low levels after vacation and lots of supplementing and my mother has hypertension. However, genetic testing is out of my price domain for now. Doctors here looked at me like a lunatic when I said I want D test.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 01:02 PM

I did K2 for few months (50-100mcg K2 MQ7) and 10K mixed A. My PTH Is 3.31 pmol/L [1.5-7.2], CRP 1.3 mg/L [0-10] and HDL is 1.2 [0.9-1.55].

Da8e709acde269e8b8bfbc09d1737841

(1906)

on September 16, 2011
at 03:11 PM

@majkinetor - Calling Kresser anti-supplementation isn't entirely accurate. The post I linked on his blog in the OP, after all, is about supplements he recommends for some people.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 01:00 PM

BTW, small question for you. I never broke a bone and I have crepitus. I was 1 month on sea, returned basically black. I did 50K IU for 2 weeks then 10K for 2 months and 1 year or so constantly fish oil (1-2tbsp and even 2 tsp, but its not liver oil). I eat eggs and butter every day and get some more from multi. My level is 33 after all that stuff.... how can that be.... the only thing that crosses my mind is history of morphea (linear scleroderma).

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:48 PM

@Namby, 100mcg not mg. Try mixed ones, like that of LEF.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:49 PM

@Quilt, yes, I suspect some genetic problem. My syster has low levels after vacation and lots of supplementing and my mother has hypertension. However, genetic testing is out of my price domain for now and things in Serbia aren't quite at latest level. Doctors here looked at me like a lunatic when I said I want D test.

77877f762c40637911396daa19b53094

(78467)

on September 18, 2011
at 03:35 PM

Thats MK4 I presume, MK7 is taken in mcg doses, right ?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 18, 2011
at 02:52 AM

Lol....namby I have a few patients with real lod HDL levels from FH who are on 45 mgs of k2 a day......they ar few and far between but their labs dictate what to do.

3
3c6b4eed18dc57f746755b698426e7c8

on September 15, 2011
at 10:26 PM

I've heard anecdotal accounts of people not catching cold once their Vit D-3 started going up above 50. I haven't heard of any negative consequences from those around me but I'm aware of the claims of kidney stones and heart arrythmia. I have been as high as the mid-90s and experienced no side effect.

But, if you're supplementing at 10,000 or 5,000 iu, it does amount to a very potent, isolated nutrient in a single dose. I do wonder what the implication of this is, since Vitamin D supplementation is a recent thing in human history. Before the 1990s, we only got D-3 through sunlight.

Why not just be slightly above 50? Like around 65 or so but not above 75? I'm now at 50 and I do plan on increasing my dose just a little, since I cut back on my dose (2,000 every other day) during the summer.

77877f762c40637911396daa19b53094

(78467)

on September 16, 2011
at 05:57 PM

Quilt, have you tried it in combination with C megadose ? There is synergy for sure. I have not been sick, together with my close friends who practice exactly the same protocol for years.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 18, 2011
at 01:31 AM

What do you mean by a C megadose? I take 500mg Vit C since I think I'm taking in at least 500mg from food sources.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:56 PM

I have had my levels above sixty for close to six yrs. No colds flu or any sickness. It's an n-1 but I found the same to be true of my patients in clinic.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 18, 2011
at 02:49 AM

Maj.....my C intake is pretty stiff.

3
Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 15, 2011
at 09:45 PM

My n=1 "evidence" is that at 91 ng/ml (tested after one year of supplementing 8,000 IUs) I haven't been sick with a virus in almost 2 years.

I have lowered my dose to 6,000 IUs and will be testing again very soon. My intention is to stay at or above 80 ng/ml.

3aea514b680d01bfd7573d74517946a7

(11996)

on September 15, 2011
at 10:04 PM

Yes, for asthma. Sorry to be unclear.

3aea514b680d01bfd7573d74517946a7

(11996)

on September 15, 2011
at 09:58 PM

Another N=1: My level in June was 78 ng/ml, and at that level I don't use my inhaler -- *ever*. (I've used it nearly daily for over 20 years.) Since my lab work in June, I've tried dropping my supps to about 60% of my former dosage, and the chest tightness came back. So I'm sticking to the high side; it has immediate physical repercussions for me.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 15, 2011
at 10:03 PM

By inhaler you mean for your asthma?

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 15, 2011
at 09:54 PM

Moved from the Pac NW to Santa Fe, so more chances to get sun. Staying on the higher end due to longstanding inflammation issues that seem to be sorting themselves out. May consider dropping down to 60 ng/ml once I feel I am where I want to be in terms of resilience.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on September 18, 2011
at 01:33 AM

Dragonfly, u mind if I ask what your weight is? My aunt (90 lber) started supplementing only 2000 per day for 3 months and is now at 95. Hard to believe. Me, a 160 lber. did 5000 per day for a year when I reached the mid 90s. D kind of creeps up on you.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 18, 2011
at 03:52 AM

I don't weigh myself anymore, but guessing ~125 lbs. Everyone's different, from what I've seen on the MDA forum. That's why testing every 6 months is a good idea.

77877f762c40637911396daa19b53094

(78467)

on September 18, 2011
at 03:36 PM

Have you checked for calcification ? That borders with hypervitaminosis.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 18, 2011
at 04:23 PM

No, majikinetor. After exhaustive reading of the available research, I am not concerned about having a "high" level. Like Rose, I have noticed I need to keep my levels in the high end to avoid any asthma symptoms. I ensure that I get sufficient A, K, and magnesium.

3864f9a2af09b1b447c7963058650a34

(3703)

on September 19, 2011
at 12:19 AM

Rose, Sondra -- I had asthma which vitamin D (+ omega-3/Mag) cleared it i[ but low thyroid and low adrenals/cortisol) are also under-appreciated factors for asthma as well.

Ce41c230e8c2a4295db31aec3ef4b2ab

(32556)

on September 18, 2011
at 03:54 AM

Oh, and I have a dark complexion, so don't get much from the sun.

77877f762c40637911396daa19b53094

(78467)

on September 18, 2011
at 03:37 PM

Have you checked for calcification ? That borders with hypervitaminosis (100ng/ml)

2
3864f9a2af09b1b447c7963058650a34

(3703)

on September 19, 2011
at 12:36 AM

Here is a good primer on vitamin D (and K2) with citations. The risk for kidney stones and cad with therapeutic replacement with bioidentical vitamin D (not D2 or drug analogues) is rare in the literature, that I could find. In fact, my sister passed 2 kidney stones and it turns out vitamin D deficiency is A RISK FACTOR FOR KIDNEY STONES (esp gluten intolerance folks). T-W-O PAINFUL KIDNEY STONES.

http://www.lmreview.com/articles/view/vitamin-d-and-vitamin-k-team-up-to-lower-cvd-risk-part-II/

"As noted in Part I of this review, the body's ability to utilize cholecalciferol in the numerous roles played by the vitamin D endocrine system is not optimized until blood levels of 25(OH)D are ???40 ng/ml (98 nmol/L). Not until this level is the Vmax, of the 25-hydroxylase enzyme achieved (i.e., are all enzyme sites saturated). Below this level, chronic substrate deficiency prevents full actualization of the myriad benefits of vitamin D.82 For some individuals, supplementation of vitamin D3 in the range of 5,000 ??? 10,000 IU/day may be necessary to reach and maintain these blood levels, which underscores the concomitant need for adequate supplies of vitamin A as well as vitamin K. The National Institutes of Health has set the RDI for vitamin A at 3,000 IU for males ??? 14 years and 2,310 IU for females ??? 14 years, and the tolerable upper limits for retinols in both men and women at 10,000 IU."

Calcium and all biochemical markers were all normal in nursing home residents provided 5000 IU (125 mcg) vitamin D3 + calcium baked in a bread bun daily for 1 year. Bone mineral density (BMD) improved for both hip and lumbar spine at the end of 1 year. [There is another study which used 5000 IU but I can't find it w/improved BMD, PTH and 25OHD.] It is a shame is someone is taking a bisphosphonate for osteopenia/-porosis when K2/Mag/Ca/D3 work better in the medical literature without causing spontaneous non-traumatic fractures, atrial fibrillation and esophageal ulcerations that are linked to these HEDIS-mandated drug class for secondary fracture prevention.

http://www.ajcn.org/content/89/4/1132/T2.expansion.html

Medium avatar

(39831)

on September 19, 2011
at 03:09 AM

For some weird reason that vitamin d/calcium bun sounds good.

1
64433a05384cd9717c1aa6bf7e98b661

(15236)

on September 16, 2011
at 03:16 AM

I came into this past summer with levels in the 60s after a winter of as much sun exposure as possible, 5-10,000 iu/day supplementing, and some tanning bed time.

Haven't supplemented all summer and got a pretty good amount of full body sun exposure. Just got my blood tests done and I'll find out on tuesday what my D level is.

For me this will be an important number. Starting out with a healthy level, whatever the sun gave me naturally will be a good number for me to strive towards via supplementation during the winter.

(I'll definitely add the results here when I get it)

33907fee54e98865a1988e5eef59147e

(480)

on September 16, 2011
at 03:26 AM

please update with a comment when the level comes back

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on September 16, 2011
at 01:55 PM

Keep us update Jeff.

64433a05384cd9717c1aa6bf7e98b661

(15236)

on September 23, 2011
at 01:07 AM

46. I'm not upset but I'm not thrilled either. I'm going to start supplementing and visiting the tanning beds.

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