High Dose Vitamin D Therapy

Answered on January 28, 2014
Created January 28, 2014 at 12:43 PM

I was on accutane for about a year - low dose 20mg. However I have been left with dry eyes and either dry skin or seborrheic dermatitis. I believe it is the latter.

Accutane is a form of vitamin A.

I read a few things on Vitamin D about it reducing/curing the toxic effects of vitamin A and about how too much of one vitamin can mess up the other.

It makes sense to me that my body may have lots of accutane stored up so I arnt getting proper levels of Vitamin D, or I need higher levels to combat the effects.

Anybody know anything about this? Or High Dose Vitamin D Therapy?

I have heard that if I decide to do High Dose Vitamin D Therapy I'd need to take vitamin K2 aswell? If thats true, how much? Or how much is a normal ratio of vitamin D to K2

Thanks alot for taking the time to read and help!


Heres a medical journal that you may wish to read before answering:

Isotretinoin is an effective therapy for severe nodulocystic acne. Several experimental studies suggest that it may have an effect on vitamin D physiology. In the present study, the authors aimed to investigate the effect of isotretinoin treatment on the metabolism of vitamin D in acne patients. A prospective analysis of 50 consecutive acne patients who were treated with isotretinoin for 3 months was done. Before and after 3 months of treatment, 25 hydroxy vitamin D, 1,25 dihydroxy vitamin D, and bone alkaline phosphatase, calcium, phosphate, and parathormone levels were measured. The 25 hydroxy vitamin D and serum calcium levels decreased significantly (p < 0.0001, p < 0.05, respectively), whereas 1,25 dihydroxy vitamin D, parathormone, and bone alkaline phosphatase levels increased significantly after 3 months of isotretinoin treatment (p < 0.005, p < 0.005, p < 0.0001, respectively). Aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels also increased significantly after isotretinoin treatment. This prospective clinical study showed that isotretinoin has an effect on vitamin D metabolism. Further clinical studies with longer periods of follow-up are needed to understand the effect of isotretinoin on vitamin D and bone metabolism.

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1 Answers



on January 28, 2014
at 02:03 PM

If anything Accutane appears to ramp up active vitamin D (1,25-dihydroxy) production. I don't think you can draw any conclusions about whether vitamin D treatment will clear Accutane faster than normal.

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