Experiences with vitamin C megadosing?

Answered on November 20, 2013
Created September 16, 2013 at 7:26 PM

Hi everyone,

I know there's been discussion here before about why to megadose vitamin C, but what I'm interested in is the experience of anyone who's tried it. I am currently getting over laryngitis and have a mild case of shingles, having just gone through a period of high stress and inadequate sleep. I've tried upping the quality of my diet - liver, lots of green leafies, oily fish every day, coconut oil, fermented cod liver oil, vegetables of as many colours as I can get my hands on - and eventually caved and began taking a prescription for Amoxicillin, but nothing seems to have had any effect and I still sound like Barry White on 40 a day.

So, I bought some vit C powder and for the past 2 days have ramped up the dose to 20,000 mg. I can't say I've noticed much difference in the shingles rash (which is in any case very small), but the difference in the laryngitis was striking. It was immediate. I've barely coughed at all, my throat has cleared and no longer hurts, it doesn't make horrible rattling noises when I breathe. I don't know if this is merely coincidence, or if there really is something to high doses of vitamin C as having powerful antiviral properties.

So far, I'm sold. I'm actually amazed. Once I'm back to normal health again I'm going to continue with a good dose each day, maybe around 5000 mg.

Has anyone else tried this? What was your experience of it?

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8 Answers


on November 20, 2013
at 10:23 AM

Did you know that all animals in the world produce vitamin C except for higher order primates, guinea pigs and fruit bats?

Did you know, mammals produce vitamin C in their livers and birds in their kidneys and the amount produced changes according to "stressors" like toxins, physical wounds, viruses etc

Did you know, an adult rat produces about 4000mg of vitamin c for itself on a normal day when it isnt sick. If this rat is provided a salmonella infected meal it can produce up to 16000mg or 16grams of vitamin c to counteract the toxins produced by salmonella!

Did you know, when scientists visited an outer island of Fiji in the 70s to measure the local diet (pre western diet) they found that an adult Fijian consumed 10grams (10,000mg) of vitamin C per day!

The recommended daily intake according to mainstream medicine is a mere 100mg per day! This is the amount required to prevent scurvy in 95% of the population. Scurvy is the ultimate lack of vitamin C and takes months without any vitamin C to develop this disease. 100mg per day is insufficient for "optimal health".

Vitamin C is actually not a vitamin but a hormone. It is normally produced in the liver of mammals which is the body's largest internal organ (skin is largest organ).

Our common ancestor with the higher order primates had a genetic mutation that prevented the last of 4 enzymatic processes that occur in the liver which convert glucose into ascorbic acid. This genetic mutation was a massive benefit to the individual as their diet (and environment) was full of fresh fruit and green leaves picked straight from trees full of vitamin C. The benefit was that they stopped converting glucose (energy) into something they had abundance of in their diet (vit c). So this provided more energy to chase girls, fight boys etc etc and was such an advantage that over time (via evolution) the genetic mutation allowed complete displacement of those that produced vit c needlessly and thus had less energy available to them.

For further information I recommend the following google searches:

Irvin Stone - free online vitamin C book

Dr Frederick Klenner - free online book

Dr Linus Pauling - read his books (many have put this great man down but he was one of the greatest scientists of all time).

Dr Robert Cathcart

Dr Thomas Levy

The Vitamin C Foundation website also has a plethora of great scientific studies for vit C.

Oh and Vitamin D (also a hormone!) is very different to Vit C however is equivalent in its benefits to the human body and most people are deficient in both!

All the best!! :D

Mike K


on September 18, 2013
at 07:10 PM

Thanks for all the insights, everyone. If anyone is interested in how effective megadosing can (apparently) be, watch this video. This man was near death and he and his family believe it was a vit C dose of up to 100g(!!) daily that saved his life:


I've had to reduce my intake dramatically as my stomach wasn't at all happy yesterday. If it's true that bowel tolerance increases with need - which certainly appears to be the case with me as I had no problems for the first couple of days at 20,000 mg - I should definitely have reduced my dose yesterday as I was feeling almost back to normal. I dropped to 7,500 mg today and have had no problems at all.

@PortlandPandy - what you say about being less stressed is interesting, as there's no doubt in my mind that stress has contributed heavily toward my suboptimal health over the past month. As you say there's evidence pointing to vitamin C as a suppressor of stress hormones, and I can honestly say that the past couple of mornings - even following one night of crappy sleep - I was in an awesome mood when walking to work, feeling happy, full of energy and ready to face the day. Coincidence? Perhaps.

@Matt 11, I hear what you're saying - of course it did occur to me that it was merely chance that my long (LONG!)-awaited recovery coincided with my vitamin C experiment. I wasn't taking 20,000 in one go - it was spread out throughout the day, so my levels would have been more constant during daylight hours at least. Of course there's no way of really knowing, but I'm convinced enough that I will try it again next time I get ill. Then again, my intention as I said in my first post is to continue at 5,000 mg/day as a preventative measure, so it may not be necessary!



on September 17, 2013
at 02:57 AM

I've used megadose vitamin C with success to treat a HSV-1 flare up. With 1g liposomal c, I repeatedly felt some side effects (increased heart rate, anxious feeling), although, I did like the flavor and the look of the concoction. I think it hits too hard too fast. I found the best route was for me to take 2g abscorbic acid when I woke up on an empty stomach, 2g before dinner, and 2g before bed for about a week. Also, around 5,000iu of d3 a day, plenty of bright vegetables, and a 100mcg k2 supplement. I've also been taking 400mcg methyl-b12, 400mcg methyl-folate, and 50mg niacin. Also, an occasional 15mg/1mg zinc/copper, and 200-400mg chelated Mg. Feels good.



on September 17, 2013
at 01:35 AM

Good question, I have not really mega dosed myself, currently upped my dose from around 1 gram per day to 2.5 to 3.5 g per day. & Thinking of going higher.

So on the topic of very high doses of Vitamin C, & to add to the conversation,

I would be interested on comments/answers/refs regarding the best form or forms to take (& ones to avoid), when taking high doses of Vitamin C long term.

From what i have read the two best forms are Ascorbic Acid and Sodium Ascorbate...

it would seem (again, from what i have read) that ascorbic acid can be a bit 'hard' on the digestion for some people, in which case sodium ascorbate should be easier on the stomach.

Ascorbic acid may also be a bit rough on the teeth (i've heard), so if using the powder/liquid form, swill your mouth with water afterwards (or brush/clean teeth).

One caveat with the high doses of sodium ascorbate is if you are watching your sodium intake, tho i doubt there are many paleo people on low salt diets.

& my 'google research' is 'telling me' to avoid high dose calcium ascorbate, as you may/will get too much calcium (calcium buildup?) with this form.


Just reading this related article, the many faces of vitamin C, which basically says that sodium ascorbate and hypertension is not a concern,

Quote: "...it appears that only sodium really results in significant fluid retention when administered with the chloride anion. Sodium when given with the anions citrate, ascorbate, or bicarbonate does not appear to adversely affect hypertension or to increase blood volume. Because of these findings, it has been directly suggested that the concept of "sodium-dependent" hypertension should be changed to "sodium chloride-dependent" hypertension (Kurtz and Morris, 1983; Kurtz et al., 1987)."


on September 17, 2013
at 12:03 AM

I won't speak for other people's bodies, but my body really likes megadoses of Vitamin C; often I go up to 10 grams daily, taken in 3-4 doses. I recommend it highly (though everyone needs to find their optimal sublaxative dose).

The major benefits: I'm a lot less stressed out (the adrenals are a major consumer of Vitamin C); my post-workout recovery is lots better; my stretch marks go down to almost nothing (which I didn't expect, but collagen formation uses up a lot of C), and any nicks, cuts, or abrasions heal much more quickly. I also get a lot of compliments on my skin when I'm dosing regularly. My gums are firmer and healthier, as well.

I use ascorbic acid crystals--which are much cheaper than tabs. The only downsides: (1) It tastes nasty/bitter, though drinking it with a pinch of salt helps; and (2) I make sure to follow doses with a couple of swigs of water, to ensure none lingers too long on my tooth enamel.



on September 16, 2013
at 08:23 PM

You were going to recover independent of vitamin C megadosing. Our bodies actually don't like excess ascorbate (vitamin C) around. Check out the pharmacokinetics. Our bodies want to keep a steady state of 100 µM of ascorbate around to do its thing. The top graph shows that to keep levels elevated, you need oral doses at regular intervals. A single megadose is nearly gone within 12 hours. IV vitamin C can achieve 100 times higher levels in serum, but is just as quickly eliminated. Humans have unique vitamin C recycling capabilities, we need a relatively tiny amount to maintain balance.


on September 16, 2013
at 07:52 PM

You might also be interested in how to make liposomal vitamin C. Haven't tried it myself, but those who have sure seem sold:




on September 16, 2013
at 07:44 PM

would also like to know the theory behind this; aswell as the normal daily optimal(and why), the RDA is less than 100 mg, yet i commonly see people recommend atleast 500 mg daily. then you have megadosing like what your talking about,(5-20g) i was under the assumption that was a bit of bs and didnt really do much?

http://paleohacks.com/questions/97030/why-megadose-vitamin-c.html (old thread about it, didnt really get a good answer and also conflicting views)

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