Why do I feel sharp decline in mood 24h after 1000mg of taurine ?

Answered on September 15, 2013
Created September 15, 2013 at 2:28 PM

I am visually impaired and suffer from PTSD. I'm looking into how diet can prevent visual decline and improve my PTSD.

On suggestion of Perfect Health Diet supplement recs, I tried 1000mg of taurine. For 24 hours I felt very calm, in control, but also energetic. After that I had a huge drop in mood in energy. This is a effect I have experienced previously when taking taurine, but now I'm wondering why this could be. Are there other people with the same problems?

What I found out so far: - Taurine influences nervous system regulation (the mode of action the brain chooses for functioning), for example by helping with GABA regulation. This is of high interest as I have PTSD, and in one study, people with PTSD had lower GABA serum levels then controls. - Taurine is involved in retinal development in embryo, as well as 1) development of retinal photorecepters 2) survival of retinal ganglian cells and 3) overall eye health. My mother was born visually impaired, and after she became a vegetarian her vision declined even more, resulting in blindness. Taurine is mostly found in rare meats. (NB: I don't assume causality) I have the same handicap as my mother, but still no decline, fortunately,, and therefore interested in preventive dietary measures. - There is a up-regulating gene (RNA, brain, retina) for taurine. That I experience a profound effect during 24 hours after taking taurine and a sharp decline after, and that it might be involved in both PTSD and my specific visual impairment, makes it of great interest to me. All feedback is incredibly appreciated.

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on September 15, 2013
at 04:03 PM

No personal experience, but I found this from an abstract in an interesting thread on anxiety:

Taurine is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. Chronic supplementation of taurine in drinking water to mice increases brain excitability mainly through alterations in the inhibitory GABAergic system. These changes include elevated expression level of glutamic acid decarboxylase (GAD) and increased levels of GABA. Additionally we reported that GABAA receptors were down regulated with chronic administration of taurine. Here, we investigated pharmacologically the functional significance of decreased / or change in subunit composition of the GABAA receptors by determining the threshold for picrotoxin-induced seizures. Picrotoxin, an antagonist of GABAA receptors that blocks the channels while in the open state, binds within the pore of the channel between the beta2 and beta3 subunits. These are the same subunits to which GABA and presumably taurine binds.


I don't suppose Jaminet's recommendation of 500-1000 mg per week would enter this territory.

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