2

votes

which is more important: T3 or T4?

Answered on August 19, 2014
Created June 15, 2012 at 2:08 PM

Would it ever make sense to take both synthroid and naturethroid? I???ve tried each in isolation, and felt much better on nature throid, but the doctor put me on synthroid anyway. I felt worse on that, so went back to nature throid, but am worried I might be missing something by not taking synthroid. I supplement with selenium, iodine (occasionally, via supplements and seaweed), vitamine D, magnesium, digestive enzymes, probiotics, and cod liver capsules (occasionally). Before taking either synthroid or nature throid, my free t3 was 1.7, tsh 1.33, ferritin 27, free t4 .82. After 3 months on nature throid, I had t3 of 76, tsh of 1.08, t4 of .84. A month later, free t3 of 2.7, t3 of 90, tsh of 1.37, and free t4 of .79. After 6 weeks of synthroid (and no naturethroid), I had tpo Ab of 12, t4 of 6.3, dhea-sulfate of 134.1, t3 of 51, tsh of .765, transferrin of 180, iron of 131, and free t4 of 1.13. So, I think the synthroid (and supplements) were working in terms of free t4, if that???s possible, but obviously not in terms of t3. Do I need both? If I can only have one (i.e., t4 via synthroid or t3 via nature throid), which is better/advisable? Overall, I can???t tell if supplementation helps, but I also don???t know if that???s mediated by the fact that I was switching from nature throid to synthroid. Either way, I???m going to continue supplementing because I don???t feel worse doing so. Is that a good approach?

I should add that I eat fairly strict paleo, and avoid gluten, soy, and dairy.

293ba4c95d190bc616b27d85b10d705a

(661)

on June 20, 2012
at 12:08 AM

Jeeze louise...

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 15, 2012
at 10:03 PM

I personally read that as Holly referring to herself with the "n=1"

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 15, 2012
at 09:09 PM

porcine thyroid replacement does not have enough T4 for many people (me) and when T3 gets too high, it can further suppress T4. such a vicious cycle and why many do best with both T4 (levothyroxine/synthroid) in combination with one of the dessicated porcine products.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 15, 2012
at 08:34 PM

So important for people to know this. Not converting is a big issue with Hashi's. I convert, but not enough.

5e5ff249c9161b8cd96d7eff6043bc3a

(4713)

on June 15, 2012
at 03:40 PM

Your statements are incongruous. You say n=1 and then that because you personally felt awful on something the OP would need both. That makes no sense.

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5 Answers

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0
4ef079c57d2140bba4dbf4e30240a645

on June 15, 2012
at 04:41 PM

Yes it makes sense! Very good sense for many people according to my ND who specializes in thyroid issues.

Ultimately, and after years of the one or the other roller coaster, I am now on both and it is absolutely best for me. After years of Hashi's (now in the negative range!) I have apparently suffered unrepairable damage and do not convert T4 to T3 well enough I am now on:

        AM 25mcg Synthroid plus 1 grain Nature-Throid

        PM 1.5 gr Nature-Throid. 

The other thing you need to know besides the issue of being able to convert T4 to T3 is that T3 (too high T3) LOWERS or suppresses T4.. such a fine balance.

I feel great (thyroid-wise) FINALLY. good luck

2
Ff1dbd6cecad1e69a8234fb2c2c5c5ed

(1409)

on June 15, 2012
at 03:35 PM

Short lecture here.

T3 is the active form, T4 is the storage hormone. A healthy thyroid will produce both.

The theory behind synthroid is that you should be able to convert T4 into T3 as needed. This works well for some people. Others have problems with conversion and benefit from taking T3.

Armour/Naturethroid is porcine thyroid and contains both, but has a higher percentage of T3 than a human thyroid will produce. So with taking naturethroid, you get both. Some people are bothered by the high percentage of T3 in natural thyroid, so they combine it with synthroid.

Personal opinion: you can juggle lab values, but what about going by how you feel? I take the local equivalent of naturethroid. I take so much that a CW doctor would send me to the next emergency room without asking. My lab values are rock-bottom despite this dose and I feel great.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 15, 2012
at 09:09 PM

porcine thyroid replacement does not have enough T4 for many people (me) and when T3 gets too high, it can further suppress T4. such a vicious cycle and why many do best with both T4 (levothyroxine/synthroid) in combination with one of the dessicated porcine products.

0
B514acafd0a6cc251279b6cb21b48941

on June 15, 2012
at 05:06 PM

The theory behind synthroid is that you should be able to convert T4 into T3 as needed. This works well for some people. Others have problems with conversion and benefit from taking T3

My body doesn't create T3 at all and naturally my T4 levels are pretty low, so I personally take armour thyroid, which provides the T3 I need, and increases my T4. Prior to taking my meds, I felt horrible, but because the symptoms for low t3 and low t4 are different, I was able to determine that it was the lack of T3 making me feel that way. (I was irritable and having anxiety attacks, my hair was thinning, I was cold all the time, etc.) By having both hormones at their proper levels - and actually my t4 is a little high, so I'm hungrier than normal - I feel much better. Through my experience, I'd say that they're equally important.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 15, 2012
at 08:34 PM

So important for people to know this. Not converting is a big issue with Hashi's. I convert, but not enough.

0
293ba4c95d190bc616b27d85b10d705a

(661)

on June 15, 2012
at 02:40 PM

n=1

i was on t3 only and i felt AWFUL so i think you need both

5e5ff249c9161b8cd96d7eff6043bc3a

(4713)

on June 15, 2012
at 03:40 PM

Your statements are incongruous. You say n=1 and then that because you personally felt awful on something the OP would need both. That makes no sense.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 15, 2012
at 10:03 PM

I personally read that as Holly referring to herself with the "n=1"

293ba4c95d190bc616b27d85b10d705a

(661)

on June 20, 2012
at 12:08 AM

Jeeze louise...

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