4

votes

What supplement made the biggest difference in how you feel?

Answered on August 19, 2014
Created December 06, 2011 at 11:54 AM

For me it was Iodoral. I'm not interested in eating seaweed everyday nor is there a good source around my area. 2nd would be selenium and 3rd magnesium.

Update March 9, 2012: I'm reneging the Iodoral, selenium, and Mg claims.

Fc6a9e07f6056d465573c8969d3a2ddd

(370)

on April 30, 2012
at 12:29 AM

Mainly constipation. Now I've dropped the D and the Mg (the Mg was making me too tired).

6bf3beba009adf49b2e2668942a432f1

on March 14, 2012
at 10:46 PM

What side effects did you start getting from Vitamin D supplementation?

9b0a4701e373d4dd13831cfb9b13f42d

(1677)

on March 09, 2012
at 10:33 PM

You are onto something

Medium avatar

(39831)

on March 09, 2012
at 10:30 PM

So...uh...what happened?

B9cc28905ec54389c47cde031d709703

on March 09, 2012
at 05:37 PM

I just wanted to be upfront and not give the impression that I was still using the stuff.

B9cc28905ec54389c47cde031d709703

on March 09, 2012
at 05:36 PM

Yes, quite sure, I can be delusional sometimes. There is, I believe, a honeymoon period with most things. In this case I spoke to soon. And it wasn't a sudden reversal, it's been reversed for a long time, but I hadn't been on here for a while. I just wanted to admit that I was wrong in my particular case. Maybe for others these things are of benefit but for me it was wrong.

B0fe7b5a9a197cd293978150cbd9055f

(8938)

on March 09, 2012
at 08:05 AM

I don't understand, Edward. You're saying those supplements made you better, then suddenly you say the opposite... So the supplements basically did nothing? Are you sure you didn't have a deficiency at first but now don't?

B9cc28905ec54389c47cde031d709703

on March 09, 2012
at 02:52 AM

Yes, straight-English: Iodoral, selenium, and Mg claims; they all made me feel like shit.

25b139cc1954456d9ea469e40f984cd3

on December 07, 2011
at 07:09 AM

YOU PROBABLY KNOW THIS, but be careful with tramadol. It isn't methadone, or oxycodone or fentanyl--all of which I've gotten off of (breaking a methadone addiction is a "unique" experience, shall I say)--but a combo of an http://en.wikipedia.org/wiki/Serotonin%E2%80%93norepinephrine_reuptake_inhibitor and an http://en.wikipedia.org/wiki/Opiod (tramadol is actually a weak opiod and a prodrug to a strong opiod) is, by definition, a highly addictive drug with a pretty nasty Effexor-meets-Vicodin withdrawal syndrome...

6b365c14c646462210f3ef6b6fecace1

(1784)

on December 06, 2011
at 07:42 PM

LOL! amen to that

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 06:20 PM

Makes sense to a layman (me included), but so does eating grains...

324bf94d3d6f9322d6e4dba4becfaab1

on December 06, 2011
at 05:59 PM

3beta-hydroxyandrost-5-ene-17-one

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 04:00 PM

And this one: http://www.ncbi.nlm.nih.gov/pubmed/18793245

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 03:57 PM

This study would contradict that. http://www.ncbi.nlm.nih.gov/pubmed/20584525

Ca2c940a1947e6200883908592956680

(8574)

on December 06, 2011
at 03:54 PM

If "feelings" are psychological then they are physiologically driven. Either that or they are just purely physiological, well unless there is a third option here.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 03:51 PM

So, fermentation is done with no heat, while standard production includes heat. Heat destroys many of the benefits of the oil. How is that reliance on unresearched marketing claims?

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:46 PM

I'm not disputing anything, except for reliance on unresearched marketing claims. majkinetor covered the PUFA question.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 03:41 PM

Yes, it increases prostate cancer risk in la-la land significantly.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 03:39 PM

Its conflict of interest I guess.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 03:39 PM

Lol @Wisper. No one is trying to convert you. This question was simply about which supplements PHers have seen actual personal benefits from taking. I was simply sharing the one that works for me. YMMV. However, I do have to ask: Are you disputing the negative impact of heat on PUFAs? If so, please provide some research to back that up.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:17 PM

Oh, looks like vit E supplementation INCREASES prostate cancer risk significantly.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:14 PM

Do you mean vit E lessnes prostate cancer risk? It's unclear from your OP.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:13 PM

So it's more of a dogmatic preference than one based on research. Got it.

A03f0d03067a43c61786481d91e5d3a0

(1078)

on December 06, 2011
at 03:06 PM

The only argument in what you provided that's relevant to me with regard to prostate cancer is that the increased risk rate is small. But it's almost certainly larger than my risk of cardiovascular problems at this age, or at any age if I eat well.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:42 PM

yeh, in one lousy study sponsored by Big Pharma. Here is rebutal: orthomolecular.org/resources/omns/v07n11.shtml

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:41 PM

yeh, in one lousy study. Here is rebutal: http://orthomolecular.org/resources/omns/v07n11.shtml

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:39 PM

Many people report that. I never heard about cravings tho. Thx for sharing.

A03f0d03067a43c61786481d91e5d3a0

(1078)

on December 06, 2011
at 02:39 PM

Vitamin E supplements are linked to prostate cancer, my primary cancer risk at my current age.

61b801de5dc345b557cd4623d4a4f26b

(2682)

on December 06, 2011
at 02:26 PM

Ditto...but I probably haven't given them a fair length of time, either.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:20 PM

good decision...

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:19 PM

bad decision.....

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:19 PM

Kewpie, heat is major problem with PUFAs, so its probably better. That said, rancidity could be tasted, and you can always add vitamin E to the mix.

3aea514b680d01bfd7573d74517946a7

(11996)

on December 06, 2011
at 02:17 PM

Well, Vitamin D3 annihilated my asthma (except when I get trapped in a house with five cats for eight hours, lol). That did a lot to improve my mood right there.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:17 PM

Maybe off topic, but I don't think difference in 'how you feel' is necessarily representative of supplement value, both positive or negative. Some negative ones (at the beginning) might be good on longer run (for instance Iodoral) while some that are hard to notice are beneficial a lot (CoQ10 for instance). This is disconnection is understandable. For example, negative effects of hyperglicemia and hypertension are mostly asympthomatic, yet may be detrimental. Its equally possible that you don't notice positive effects of supplement. Context is important in judgement

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:16 PM

Maybe off topic, but I don't think difference in 'how you feel' is necessarily representative of supplement value, both positive or negative. Some negative at start ones might be good on longer run (for instance Iodoral) while some that are hard to notice are beneficial a lot (CoQ10 for instance). This is disconnection is understandable. For example, negative effects of hyperglicemia and hypertension are mostly asympthomatic, yet may be detrimental. Its equally possible that you don't notice positive effects of supplement. Context is important in judgement.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 01:44 PM

I eat whole foods. I don't generally take supplements because they are not whole foods. Fermented cod liver oil is a whole food that is very minimally processed in a way that does not require any of it's essential nutrients to be added back in because they were lost in the processing. I'm not sure what kind of research you would need to know that heat destroys the nutrients in fish oils--just as it does in many other oils. This is pretty basic chemistry. Just as I would never use industrial seed oils, I would never use industrial fish oil.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 01:19 PM

Define "problematic." I'm not looking for a feeling, attacking other supplements just because they are found at Wal-Mart, or regurgitating marketing material; I'm after research.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 01:13 PM

Non-fermented is processed with heat which could be problematic. Additionally, I feel better about the quality of ingredients and the integrity of the process used by the company producing the fermented cod liver oil (there is currently only one) as opposed to something I would find on the shelf at Wal-Mart. Some of the other cod liver oils are so processed vitamins A & D are removed in the process and have to be added back in.

A968087cc1dd66d480749c02e4619ef4

(20436)

on December 06, 2011
at 12:54 PM

Is Tramadol a supplement?

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 12:14 PM

What's the difference between non-fermented when it comes to vitamins and other benefits? The quick googling I did only came up with marketing claims unsubstantiated by independent research - or any research.

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18 Answers

best answer

6
B3c62d89cd47b7d7209b6a99243d0ded

on December 06, 2011
at 03:46 PM

Coffee has done wonders for me!

6b365c14c646462210f3ef6b6fecace1

(1784)

on December 06, 2011
at 07:42 PM

LOL! amen to that

7
Da3d4a6835c0f5256b2ef829b3ba3393

on December 06, 2011
at 12:20 PM

I don't get any immediate feedback from any supplements I take except for maybe lower triglycerides from fish oil. Basically, I'm just trusting the science for the stuff I take, which is fish oil, vitamins D, K2 and C, and magnesium.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:20 PM

good decision...

3
7842808cd699f35741248f8e55c776bd

(218)

on December 06, 2011
at 02:48 PM

Vitamin D for sure has been a huge mood improver for me. I didn't notice this, however, until I took it regularly for a few months, then went off it. Suffice it to say I turned into quite a sour puss! As soon as I started taking it again I felt AMAZING (and continue to). I take fish oil as well, but I don't really notice much difference in how I feel.

3
Ca2c940a1947e6200883908592956680

(8574)

on December 06, 2011
at 12:27 PM

In terms of mood: I started 1500iu of Vitamin D3 and 2000mg of Omega3 Fish Oil at the same time and I do think my mood has improved quite considerably.

Last week I started taking 30mg of Zinc and 450mg of Magnesium before bed, and I am waking up without my alarm exactly at 6:20am which is amazing for me!

The other two which have made a big difference are 5000mg of Creatine and 5000mg of BCAA which have really given me so much more general motivation and strength to continue working out, even if it's just 20 pull-ups before dashing off to work.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:39 PM

Many people report that. I never heard about cravings tho. Thx for sharing.

3
13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 12:02 PM

Fermented cod liver oil. It's made a big difference in my mood.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 03:39 PM

Lol @Wisper. No one is trying to convert you. This question was simply about which supplements PHers have seen actual personal benefits from taking. I was simply sharing the one that works for me. YMMV. However, I do have to ask: Are you disputing the negative impact of heat on PUFAs? If so, please provide some research to back that up.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 01:44 PM

I eat whole foods. I don't generally take supplements because they are not whole foods. Fermented cod liver oil is a whole food that is very minimally processed in a way that does not require any of it's essential nutrients to be added back in because they were lost in the processing. I'm not sure what kind of research you would need to know that heat destroys the nutrients in fish oils--just as it does in many other oils. This is pretty basic chemistry. Just as I would never use industrial seed oils, I would never use industrial fish oil.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 12:14 PM

What's the difference between non-fermented when it comes to vitamins and other benefits? The quick googling I did only came up with marketing claims unsubstantiated by independent research - or any research.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:46 PM

I'm not disputing anything, except for reliance on unresearched marketing claims. majkinetor covered the PUFA question.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:19 PM

Kewpie, heat is major problem with PUFAs, so its probably better. That said, rancidity could be tasted, and you can always add vitamin E to the mix.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:13 PM

So it's more of a dogmatic preference than one based on research. Got it.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 03:51 PM

So, fermentation is done with no heat, while standard production includes heat. Heat destroys many of the benefits of the oil. How is that reliance on unresearched marketing claims?

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 01:13 PM

Non-fermented is processed with heat which could be problematic. Additionally, I feel better about the quality of ingredients and the integrity of the process used by the company producing the fermented cod liver oil (there is currently only one) as opposed to something I would find on the shelf at Wal-Mart. Some of the other cod liver oils are so processed vitamins A & D are removed in the process and have to be added back in.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 01:19 PM

Define "problematic." I'm not looking for a feeling, attacking other supplements just because they are found at Wal-Mart, or regurgitating marketing material; I'm after research.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 03:39 PM

Its conflict of interest I guess.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 06:20 PM

Makes sense to a layman (me included), but so does eating grains...

2
Medium avatar

on December 06, 2011
at 03:41 PM

With most supplements there's no basis for evaluating differences in how one feels. Dummy pills would probably have the same "effect." Placebo 101.

Just to be clear: I'm talking about supplements and their discernable causal effect on "feelings," not saying supplements have no bodily effects.

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 03:57 PM

This study would contradict that. http://www.ncbi.nlm.nih.gov/pubmed/20584525

13a44ea00b0c9af0b6d0f3d5f5c2cfca

(7223)

on December 06, 2011
at 04:00 PM

And this one: http://www.ncbi.nlm.nih.gov/pubmed/18793245

Ca2c940a1947e6200883908592956680

(8574)

on December 06, 2011
at 03:54 PM

If "feelings" are psychological then they are physiologically driven. Either that or they are just purely physiological, well unless there is a third option here.

2
5ef574d7893bc816ec52e04139e9bc09

(6097)

on December 06, 2011
at 01:24 PM

No supplement has ever made a difference in how I feel.

61b801de5dc345b557cd4623d4a4f26b

(2682)

on December 06, 2011
at 02:26 PM

Ditto...but I probably haven't given them a fair length of time, either.

2
559a1bf85bfe38a0fbbf56377c7278b4

on December 06, 2011
at 12:23 PM

Alpha lipoic acid is tremendous for insulin resistance / carb intolerance and can give relief from cravings within less than half an hour.

2
A03f0d03067a43c61786481d91e5d3a0

(1078)

on December 06, 2011
at 12:17 PM

I haven't noticed any change in mood between my fish oil, magnesium, vitamin D and E (since abandoned).

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:41 PM

yeh, in one lousy study. Here is rebutal: http://orthomolecular.org/resources/omns/v07n11.shtml

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:17 PM

Oh, looks like vit E supplementation INCREASES prostate cancer risk significantly.

9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 03:14 PM

Do you mean vit E lessnes prostate cancer risk? It's unclear from your OP.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:42 PM

yeh, in one lousy study sponsored by Big Pharma. Here is rebutal: orthomolecular.org/resources/omns/v07n11.shtml

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 02:19 PM

bad decision.....

A03f0d03067a43c61786481d91e5d3a0

(1078)

on December 06, 2011
at 03:06 PM

The only argument in what you provided that's relevant to me with regard to prostate cancer is that the increased risk rate is small. But it's almost certainly larger than my risk of cardiovascular problems at this age, or at any age if I eat well.

77877f762c40637911396daa19b53094

(78467)

on December 06, 2011
at 03:41 PM

Yes, it increases prostate cancer risk in la-la land significantly.

A03f0d03067a43c61786481d91e5d3a0

(1078)

on December 06, 2011
at 02:39 PM

Vitamin E supplements are linked to prostate cancer, my primary cancer risk at my current age.

1
Bee4e0fda817da9857443bd40f552a75

on December 07, 2012
at 06:12 PM

Vitamin D3 and magnesium.

1
77877f762c40637911396daa19b53094

(78467)

on March 09, 2012
at 08:39 PM

Licorice powder allowed me to stop taking 20 mg of hyrocortisone(Cortef). alpha lipoic acid is chelating mercury from my brain/body. ashwaganda is terrific for bedroom activities.My wife can always tell.She's mentioned it the last four times I've taken it.

1
1dcfcebc5f36408d121f124a78292d42

on March 09, 2012
at 02:20 PM

Vitamin D3, a good quality fish oil supplement (I like Nordic Naturals), and a good quality probiotic. Those are my foundational supplements, and I definitely don't feel right if I don't take them consistently.

After that, I will sometimes supplement with holy basil, turmeric, and magnesium.

9b0a4701e373d4dd13831cfb9b13f42d

(1677)

on March 09, 2012
at 10:33 PM

You are onto something

1
66974b2cb291799dcd661b7dec99a9e2

(11121)

on December 06, 2011
at 03:57 PM

I seem to benefit from Vit D + Chromium - almost seems to give me extra energy.

1
9f54852ea376e8e416356f547611e052

(2957)

on December 06, 2011
at 01:16 PM

ZMA is the only supplement I've ever taken which has any noticeable psychological effect on me. It improves my sleep tremendously, and I get a headache the following day if I take it "wrong" - it is supposed to be taken on an empty stomach before going to bed.

It's a patented zinc and magnesium blend, and doesn't use a mixing agent found in non-ZMA zinc-magnesium supplements. The agent prevents either zinc or magnesium from absorbing properly (don't remember which one, and what that agent is).

I did notice improvement on my skin when I started taking fish oil, and later moved to cod liver oil - I used to get the occasional pimple before that. I had bad acne as a teenager, Roaccutane fixed most of it.

For others - probiotics, C/D/K vitamin, BCAA, creatine - never noticed any difference whatsoever mentally or physically. I trust the research.

0
5623f2e264246a497fce7c4a7e00f6d2

on December 07, 2012
at 06:19 PM

I feel better when I take fermented cod liver oil

I sleep better and am less prone to "crazy legs" (aka restless legs syndrome) when I take natural calm.

FWIW: I added in FCLO, mega doses of D3 (8k IU) plus being more intentinal with the coconut oil around the same time. But since I track of a lot of other data as well, I ovulated for the first time in months 5 weeks after starting that protocol

0
1c67bc28f4e44bbb8770b86df0463df3

on March 09, 2012
at 08:20 PM

Vit D FTW, with calcium.

0
Fc6a9e07f6056d465573c8969d3a2ddd

(370)

on March 09, 2012
at 07:01 PM

Bifera (for my borderline anemia) and D3, plus Mg to offset some unfortunate side effects that appeared when I started supplementing Vitamin D.

6bf3beba009adf49b2e2668942a432f1

on March 14, 2012
at 10:46 PM

What side effects did you start getting from Vitamin D supplementation?

Fc6a9e07f6056d465573c8969d3a2ddd

(370)

on April 30, 2012
at 12:29 AM

Mainly constipation. Now I've dropped the D and the Mg (the Mg was making me too tired).

0
A2c38be4c54c91a15071f82f14cac0b3

(12682)

on March 09, 2012
at 02:49 AM

People seem to be exclusively focusing on supplements that made a positive difference in how they felt. Mine did the opposite. A while back (maybe 2 years ago) I started taking 5-htp for sleep issues and depression. It made me feel terrible. At first it worked a little bit. Then it seemed to stop helping. Then I started feeling off, eventually getting headaches and random bouts of anxiety. These stopped quite soon after I trashed the stuff.

B9cc28905ec54389c47cde031d709703

on March 09, 2012
at 02:52 AM

Yes, straight-English: Iodoral, selenium, and Mg claims; they all made me feel like shit.

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