2

votes

What makes this supplement work so well?

Answered on August 19, 2014
Created November 08, 2011 at 5:33 AM

Ive been taking this supplement for a week now and it does work great. But its super expensive. One of the owners of the company openly tells people to copy the formula if they like it but cant afford it. Some of the ingredients such as AC-11 cant be found easily but like most supplement formulas Im guessing that only a handful of the ingredients provide all of the benefits.

Ingredients are listed on the right side in a pop down menu. http://www.onnit.com/alphabrain/

Side note but my personal philosophy is evolving from Paleo only to Paleo is the BEST hands-down base out there and is essential. But once you get your food, sleep, exercise, social interactions, stress, needed supplements, natural products down then you can tweak your operating system for optimal performance. Just like how my engineer buddy rewrote his car computer for better performance and better gas mileage. I am the type of person that needs 9 hrs sleep, and close to a perfect diet so supplements such as this allow me to compete with the "normal" working world and do my best.

Edit: Here is the ingredient list and some science behind it.

Choline:

http://www.ncbi.nlm.nih.gov/pubmed/1428296

http://www.ncbi.nlm.nih.gov/pubmed/15640516

Huperzine A

http://www.webmd.com/vitamins-supplements/ingredientmono-764-HUPERZINE%20A.aspx?activeIngredientId=764&activeIngredientName=HUPERZINE%20A

Vinpocetine:

http://www.drugs.com/npp/vinpocetine.html

Bacopa:

http://en.wikipedia.org/wiki/Bacopa_monnieri#Physiological_Effects

Pterostibene (looks like its not brain related)

http://www.ars.usda.gov/is/AR/archive/nov06/health1106.htm

Mucuna Pruriens

http://jnnp.bmj.com/content/75/12/1672

GABA - Im curious if this can cross the brain-blood barrier

Oat Straw - ??

AC-11

http://www.optigenex.com/ac11.htm#Important_Links_to_AC-11??_Science

B6 - we are all familiar with this

77877f762c40637911396daa19b53094

(78467)

on September 07, 2013
at 01:28 AM

I am sure somebody will post this one so let me do it in advance: http://www.sciencebasedmedicine.org/index.php/alpha-brain-whats-wrong-with-the-supplement-industry/

B22e5946e28a1845a6006737e59edfc6

(2437)

on March 06, 2013
at 04:08 AM

Year later and I still take it. Amazing but I also have ADD so perhaps it helps those with dopamine issues.

696079a860ef54810406ae25e4650863

(1623)

on November 14, 2011
at 02:04 PM

BTW, I've read that GABA is supposed to be too large to cross the blood brain barrier... One of the ways to diagnose a 'leaky brain' situation is by taking GABA and seeing if it actually relaxes you quickly(within 15 min or so) if so it presumably means you have too much permeability to your BBB. (sorry, no references- read this a while ago and it just stuck with me- perhaps someone else has the references/ciations.)

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 14, 2011
at 03:11 AM

Have you tried the pills you linked to? Ive tried Russian adaptogens before with bad results. Im hesitant to try a product containing a Russian nootropic.

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 14, 2011
at 03:08 AM

I hope that Im one of the ones who report the "continuous state of well being." These things are the shiz!

6cca02352c216b4ca8325fda7d83832c

(1042)

on November 08, 2011
at 09:49 PM

One of my favorite movies. A science fiction metaphor for what happens when one transitions from a modern lifestyle to a Paleo lifestyle? I agree that the experience of the person asking this question closely resembles the experience of the main character in that movie.

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 02:32 PM

okay you win one point because I mis-spelled nootropic

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 02:31 PM

Please stop with the strawmen. I never said animal studies are irrelevant. Animal studies have their place, as a first step before human studies. If you want to put your trust in rat fetuses, that's your choice.

77877f762c40637911396daa19b53094

(78467)

on November 08, 2011
at 09:42 AM

BTW, concel, nootropics do not seem to work for some people. I am basing that on my experience from more then my N=1 case

77877f762c40637911396daa19b53094

(78467)

on November 08, 2011
at 09:42 AM

BTW, concel, nootropics do not seem to work for some people. I am basing my experience from more then my N=1 case.

77877f762c40637911396daa19b53094

(78467)

on November 08, 2011
at 08:59 AM

Conceilliator, so you think that animal studies are not relevant to humans ? If so, we should probably ban all drugs in existence.

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 07:31 AM

"as someone who once looked deeply into neutropics" A) Most studies are done one rats at first. B) Im glad youve studied neutropics which are viruses but Im addressing nootropics :-)

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 07:27 AM

A) Most studies are done one rats at first. B) Im glad youve studies neutropics which are viruses but Im addressing nootropics :-)

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:43 AM

Yeah misspellings abound above. No I didnt take it today :-)

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:41 AM

...octane of your fuel. Taking this without getting all cylinders firing first would be a waste as would get minimal gain. But once the engine is running nicely perhaps it gives an extra boost?

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:41 AM

Yeah Id be curious to see what Dr K has to say. Ive taken astaxanthin before to improve my night vision (study out of Japan proved its legit) but it didnt make me more alert, sharp, motivated and focused like this supp. Plus Im stronger in the gym and can do more physical work. Once again, my stanford bud hacks all of his electronics making them work better and last longer. I think that once you have all your ducks in a row these supps can possibly help. Paleo make your 8 cylinder thats only firing on 4 cylinders fire on all eight again. This just seems to maximize the...

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:36 AM

@ concilator. I already meditate, I already go to a chan (chinese zen) center, I already have used binaural beats. I just posted some studies to all but one of the ingredients used

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:29 AM

I am not saying this supplement does not do something. But you asked why it works so well. For that, the only answer is the placebo effect. All the good chemicals aren't legal :(

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:19 AM

Meditation is probably more useful, and free.

Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on November 08, 2011
at 06:19 AM

You would have to go into the biochemistry of it, right? It claims antioxidant, anti-inflammatory, immune-boosting and other properties. Sounds like astaxanthin which I take. Basically keeps your neurons in a good state so everything flows nicely, I think. I'm sure Dr. K will come along and actually explain this stuff in technical jargon. There may be more than just the health of the cells.

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:17 AM

Choline is in eggs, I eat eggs. I think most people here eat eggs or liver.

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:16 AM

Straw men are fun.

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:16 AM

Here is the very first ingredient. http://www.ncbi.nlm.nih.gov/pubmed/15640516

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:11 AM

Yeah, the paleo diet is a placebo as well. Be sure to stack up on bagels and corn flakes tomorrow morning. Its all in your head

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7 Answers

5
07ca188c8dac3a17f629dd87198d2098

(7970)

on November 08, 2011
at 01:54 PM

This reminds me of the movie Limitless. Please note that it's a work of fiction ;-)

6cca02352c216b4ca8325fda7d83832c

(1042)

on November 08, 2011
at 09:49 PM

One of my favorite movies. A science fiction metaphor for what happens when one transitions from a modern lifestyle to a Paleo lifestyle? I agree that the experience of the person asking this question closely resembles the experience of the main character in that movie.

4
Cf32992bfa1907147c7cdc451bba9c63

on November 08, 2011
at 06:02 AM

The placebo effect is incredibly powerful. Don't believe the naysayers who tell you it isn't real!

And last I read, research says the placebo effect is actually getting stronger as time goes by.

In response to your studies:

Choline Study 1

  1. Uses intramuscular injections, not relevant
  2. Conclusion is simply that it raises choline levels, again not relevant
  3. Uses a choline precursor

Choline Study 2

  1. Used rats. You're not a rat.
  2. Used pups/babies. You're not a baby.
  3. Mentioned that choline is present in real foods, e.g. eggs. Why supplement?

Huperzine Study

  1. This isn't a study, it's webmd. I did find This study which showed a miniscule difference. I am too busy to run the statistics tests but 115+/-6 is not much better than 104+/-9.

Vinpocetine

  1. Drugs.com?

Bacopa

  1. Wikipedia? And on rats?

I'll get to the rest later, going to sleep. If you want to take this opportunity to find relevant statistically significant AND meaningful human studies, be my guest.

My honest advice to you, as someone who once looked deeply into nootropics, is spend less time worrying about getting smarter and more time studying what you want to be smart at.

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 07:31 AM

"as someone who once looked deeply into neutropics" A) Most studies are done one rats at first. B) Im glad youve studied neutropics which are viruses but Im addressing nootropics :-)

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:11 AM

Yeah, the paleo diet is a placebo as well. Be sure to stack up on bagels and corn flakes tomorrow morning. Its all in your head

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 07:27 AM

A) Most studies are done one rats at first. B) Im glad youve studies neutropics which are viruses but Im addressing nootropics :-)

77877f762c40637911396daa19b53094

(78467)

on November 08, 2011
at 09:42 AM

BTW, concel, nootropics do not seem to work for some people. I am basing my experience from more then my N=1 case.

77877f762c40637911396daa19b53094

(78467)

on November 08, 2011
at 09:42 AM

BTW, concel, nootropics do not seem to work for some people. I am basing that on my experience from more then my N=1 case

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:16 AM

Straw men are fun.

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:17 AM

Choline is in eggs, I eat eggs. I think most people here eat eggs or liver.

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:16 AM

Here is the very first ingredient. http://www.ncbi.nlm.nih.gov/pubmed/15640516

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 02:32 PM

okay you win one point because I mis-spelled nootropic

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:29 AM

I am not saying this supplement does not do something. But you asked why it works so well. For that, the only answer is the placebo effect. All the good chemicals aren't legal :(

77877f762c40637911396daa19b53094

(78467)

on November 08, 2011
at 08:59 AM

Conceilliator, so you think that animal studies are not relevant to humans ? If so, we should probably ban all drugs in existence.

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 06:19 AM

Meditation is probably more useful, and free.

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 08, 2011
at 06:36 AM

@ concilator. I already meditate, I already go to a chan (chinese zen) center, I already have used binaural beats. I just posted some studies to all but one of the ingredients used

Cf32992bfa1907147c7cdc451bba9c63

(2890)

on November 08, 2011
at 02:31 PM

Please stop with the strawmen. I never said animal studies are irrelevant. Animal studies have their place, as a first step before human studies. If you want to put your trust in rat fetuses, that's your choice.

1
77877f762c40637911396daa19b53094

(78467)

on November 08, 2011
at 08:55 AM

Those are all well known nootropics that in synergy produce better effect [or some effect] then taken alone. Its not placebo, that is for sure. I don't know about this one you bought, but some people report diminishing returns, on the other hand, some report continuous state of well being.

There is a lot of science behind it, its easy to find and most of them are used for more then 50 years. Piracetam, for instance, has millions of users worldwide and its used to regenerate brain cells after stroke. Some of it tend to be suppressed because nobody wants smarter people.

I don't think those should be taken constantly - its probably the best to use them few bottles a year, when extensive thinking is required.

Concilator obviously never tried the stuff. I suggest him GetSmart for the start and then he can decide if to call it placebo or not. Even if it is placebo, as concilator claims, its a good thing.

77877f762c40637911396daa19b53094

(78467)

on September 07, 2013
at 01:28 AM

I am sure somebody will post this one so let me do it in advance: http://www.sciencebasedmedicine.org/index.php/alpha-brain-whats-wrong-with-the-supplement-industry/

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 14, 2011
at 03:08 AM

I hope that Im one of the ones who report the "continuous state of well being." These things are the shiz!

B22e5946e28a1845a6006737e59edfc6

(2437)

on November 14, 2011
at 03:11 AM

Have you tried the pills you linked to? Ive tried Russian adaptogens before with bad results. Im hesitant to try a product containing a Russian nootropic.

0
96440612cf0fcf366bf5ad8f776fca84

(19463)

on September 07, 2013
at 12:44 AM

The first bunch of those ingredients is in FocusFactor.

0
6b49bc0bbcba984eaefc3f188fd933e0

(0)

on February 27, 2013
at 10:38 PM

I have tried this supplement Alpha Brain and I felt a difference almost immediatley after taking it.

B22e5946e28a1845a6006737e59edfc6

(2437)

on March 06, 2013
at 04:08 AM

Year later and I still take it. Amazing but I also have ADD so perhaps it helps those with dopamine issues.

0
Medium avatar

(3029)

on November 14, 2011
at 01:16 PM

You say it works great. What does it actually do for you? Do you feel clear changes that you can safely ascribe to the supplement?

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