Can you become "vitamin resistant" like one can become insulin resistant with large doses of vitamins in non-physiologic doses so that there are tons of vitamins but receptor sites not accepting them so that then you need more and more of them to get the same result? With chronic long term supplementation.
asked byThinnerStrength (2204)
Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!
on October 06, 2012
at 04:41 AM
Whenever you have a chronic excess of ligand binding to a receptor and the activation of that receptor is coupled to a negative feedback loop which downmodulates the genetic expression of that receptor, then you can induce 'resistance' as you describe. This is one of the ways in which homeostasis is mediated.
It would follow that people could potentially experience a form of malnutrition if they were to go from hypervitaminosis to a normovitaminosis during the period of adjustment, but there is no evidence of any such effect being recorded. This is not to say such an effect may not occur, however.