5

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Pyroluria and Paleo

Answered on August 19, 2014
Created September 13, 2011 at 11:34 PM

Pyroluria-- Is it real? Is it permanent? Those that pay attention to it regard it as genetic, requiring permanent B6 supplementation. Nora Gedgaudas in "Primal Mind Primal Body" has a whole appendix on it and seems to share this view. Any experience reversing this dependency with Paleo diet/lifestyle? Or other perspectives, experiences out there?

Just to be clear- I'm talking pyroluria, the theoretical B6 pathway dysfunction.

543a65b3004bf5a51974fbdd60d666bb

(4493)

on March 22, 2013
at 01:45 AM

hi Harry, just in case you are monitoring this. i recently posted a couple of questions to you on your web site, here, http://www.myhealthjourney.info/carnitine-deficiency/ Which i think may have got stuck in your spam filter...thx

6eb2812b40855ba64508cbf2dc48f1b6

(2119)

on August 01, 2012
at 06:13 PM

I've doubled my zinc supplements and added METHYLATED B vitamins (inc. B6) and I actually remembered a dream when I woke up this morning! I typically have no dream recall, so that's something for me.

C8b2136ef95ba6aac211825ff38cc0e9

(971)

on July 22, 2012
at 05:47 PM

I had never heard of this. The list of symptoms pretty much describes my life. Also, B6 supplementation seems to have a positive effect for me. Interesting.

47a42b6be94caf700fce9509e38bb6a4

(9647)

on September 14, 2011
at 01:00 AM

Yes, I assumed you had mistyped polyuria in your question also ....

3f11b5fda91063846bba45daac3541bd

(1186)

on September 14, 2011
at 12:36 AM

The question is regarding pyroluria which is a theoretical dysfunction in B6 and zinc metabolism. Great answer for polyuria (frequent urination) though!! :)

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5 Answers

5
5b5b7efa9b3df6c2d80e43883e4957c1

on May 16, 2012
at 10:56 AM

Oh its real alright. I have Pyroluria, it took me 8 years to work out what caused all my symptoms, these symptoms included:

  • Brain fog
  • Poor concentration and memory
  • Depression
  • Anxiety
  • Chronic fatigue (really adrenal fatigue)
  • Digestive issues

I've known for a year that I actually suffer from Pyroluria and it took a bit of working out but the Pyroluria supplements have turned me back into a normal person. I tried so many different treatments before I was diagnosed with Pyroluria.

It's not just zinc and vitamin B6 I take. I also take other supplements such as P5P, manganese, Evening Primrose oil, vitamin b3, biotin, vitamin E, vitamin C, magnesium, vitamin D to name a few.

I believe the condition is life long and cannot be 'cured'. But I would be very happy to be proven wrong on this belief. Seems genetic to me from what I have read and see in other family members.

I also think it is best to not go untreated as it leads to copper buildup in your body, from the low zinc levels.

I blog about living life with Pyroluria at: http://pyrolurialife.com

6eb2812b40855ba64508cbf2dc48f1b6

(2119)

on August 01, 2012
at 06:13 PM

I've doubled my zinc supplements and added METHYLATED B vitamins (inc. B6) and I actually remembered a dream when I woke up this morning! I typically have no dream recall, so that's something for me.

543a65b3004bf5a51974fbdd60d666bb

(4493)

on March 22, 2013
at 01:45 AM

hi Harry, just in case you are monitoring this. i recently posted a couple of questions to you on your web site, here, http://www.myhealthjourney.info/carnitine-deficiency/ Which i think may have got stuck in your spam filter...thx

2
559a1bf85bfe38a0fbbf56377c7278b4

on November 18, 2011
at 11:13 AM

I suspected I might have pyoluria and benefited a lot from B6 supplementation. I don't think zinc supplements on their own made anywhere near so much difference. Sometimes I find I need magnesium, sometimes I don't. At the moment I take a multimineral. I am sure eating paleo (and reducing stress) has helped but I'm going to try B6 again to see if I'm even better with both paleo and B6. If I am better with both, I will be a bit more persuaded that it is real.

1
C8a5c6d2804326646bb274e491f7f21b

on January 03, 2013
at 02:48 PM

Great post. WAPF witnessed most primitive cultures eating some raw meat, clearly they were lacking something without it. They include vitamin b6 discussion in this article:

http://www.keeperofthehome.org/2008/07/the-health-benefits-of-eating-raw-meat.html

1
1e37ebcdd71f0a21bff953a418db8d87

on January 02, 2013
at 10:12 PM

Look into Pyroluriatesting.com !!

0
095ef76482234d3db444b77d7ed01c29

(2755)

on September 14, 2011
at 12:24 AM

I've actually found that most often when someone first changes to paleo, primal, or any other ancestral eating way of life where they are eating much less carbs than they were before, they often get into ketosis. Ketosis is where the body is producing ketones as the byproduct of lypolosis, or the burning of fat for energy. It happens faster with the higher fat ways of eating, slower with the lower fat ways, but eventually with reduced carbs from legumes, grains, and grain products...especially if even tubers and dairy are eliminated too. This is different from diabetic ketoacidosis which is the product of very high blood glucose levels...in fact it's quite the opposite, it's the product of a low-normal BGL with resulting fat burning.

What ketones aren't utilized for energy are eleminated from the body in the urine. Often, especially at first, this is manifested as polyuria. This is a good thing. Remember that every 1 gram of carbohydrate in the body holds 4 grams of water, since you have less glucose, glycogen and other carbohydrates available you get rid of the water and the excess ketones by urinating more.

It's not a bad thing at all. Just for a couple of weeks, you think you might actually pee out a kidney. Don't worry, your system is just reaching homeostasis (balance) and all is well.

3f11b5fda91063846bba45daac3541bd

(1186)

on September 14, 2011
at 12:36 AM

The question is regarding pyroluria which is a theoretical dysfunction in B6 and zinc metabolism. Great answer for polyuria (frequent urination) though!! :)

47a42b6be94caf700fce9509e38bb6a4

(9647)

on September 14, 2011
at 01:00 AM

Yes, I assumed you had mistyped polyuria in your question also ....

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