6

votes

Is there any benefit to supplementing with Glutathione?

Answered on April 22, 2016
Created March 09, 2011 at 5:02 AM

Recently a friend of mine became an agent for MaxOne glutathione and is trying to convince me it is the best thing since sliced bread. Well we know how good sliced bread is!

I haven't been able to find any independent research on the product. Plus most of the chatter on the net seems to be slugfests between skeptics vs those selling the stuff with little science backing up either view.

Links to research/your experience much appreciated.

And if this is the real deal, is there a cheaper no-name variety one should look at?

56fa5f31142f8e886269ebcf45f4822b

(0)

on June 24, 2014
at 05:01 PM

Glutathione is an approved dietary supplement, not a drug. It is available from a variety of sources.

56fa5f31142f8e886269ebcf45f4822b

(0)

on June 24, 2014
at 04:59 PM

There are no human studies on Acetyl Glutathione, only animal and studies supporting reduced glutathione are referenced. If you know of any please post the links, I would like to see them.

56fa5f31142f8e886269ebcf45f4822b

(0)

on June 24, 2014
at 04:57 PM

A new study in the European Journal of Nutrition shows that oral glutathione supplements are available to the body and have a positive immune benefit.

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione.

http://www.ncbi.nlm.nih.gov/pubmed/24791752

an>

96440612cf0fcf366bf5ad8f776fca84

(19413)

on May 10, 2014
at 01:16 PM

Except that glutathione is broken down during digestion, and must be liposomally coated or in another form (acetyl I believe), to make it past the gut lining intact. This is a key factor if you're going to supplement with it.

7147c5a67e8bf852b4a511085a239e09

on October 07, 2013
at 03:13 PM

We now have answers that indicate that YES, oral supplementation of glutathione does work. See answer below with details.

7147c5a67e8bf852b4a511085a239e09

on October 07, 2013
at 03:12 PM

This answer is no longer entirely valid: "1,000 mg dose [of glutathione] increased GSH levels in many physiological compartments, while 250 mg dose increased GSH in whole blood." NK, natural killer, cells cytotoxicity were increased two fold as well. So the answer now is YES, oral glutathione supplementation DOES work! See: "Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation" in Experimental Biology 2013 (April 22, 2013).

D396b126240f584bc358e6e4fd84e9e3

(455)

on August 29, 2013
at 01:55 AM

Good tip and I've thought about doing this myself since both liposomal GSH and vitamin C are insanely expensive.

D396b126240f584bc358e6e4fd84e9e3

(455)

on August 29, 2013
at 01:51 AM

Actually, there is some evidence that a liposomal formulation of GSH is absorbable.

96440612cf0fcf366bf5ad8f776fca84

(19413)

on August 28, 2013
at 06:18 PM

Because it isn't a patented drug that they can exclusively sell. If it were, you'd see ads on TV for it every few hours like crazy, "ask your doctor." Glutathione is produced endogenously by everyone, provided we have the right precursors and are healthy. It's our master antioxidant.

7e65e7c3794834b3526b77f92cabee55

(214)

on March 09, 2011
at 06:29 AM

Thanks. The MaxOne claim is that it is "300% more effective than NAC" - but I find nothing to back this up.

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24 Answers

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7
86f9e83c849a70233b6bf4b78d249d0f

on March 09, 2011
at 05:23 AM

Negative, taking a glutathione supplement is worthless. The body cannot absorb dietary glutathione. Rather, the body assembles GSH (glutathione) by using three amino acids: cysteine, glutamine, and glutamic acid.

If you're interested in naturally boosting your GSH via supplementation, your best bet is to take some NAC (N-Acetyl Cysteine) and increase the amount of antioxidants you're currently taking in (eat more greens).

Raw dairy such as unpasteurized whey (if you can get your hands on it, it's really expensive and hard to find) or plain raw milk also boost GSH.

7e65e7c3794834b3526b77f92cabee55

(214)

on March 09, 2011
at 06:29 AM

Thanks. The MaxOne claim is that it is "300% more effective than NAC" - but I find nothing to back this up.

D396b126240f584bc358e6e4fd84e9e3

(455)

on August 29, 2013
at 01:51 AM

Actually, there is some evidence that a liposomal formulation of GSH is absorbable.

7147c5a67e8bf852b4a511085a239e09

on October 07, 2013
at 03:12 PM

This answer is no longer entirely valid: "1,000 mg dose [of glutathione] increased GSH levels in many physiological compartments, while 250 mg dose increased GSH in whole blood." NK, natural killer, cells cytotoxicity were increased two fold as well. So the answer now is YES, oral glutathione supplementation DOES work! See: "Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation" in Experimental Biology 2013 (April 22, 2013).

56fa5f31142f8e886269ebcf45f4822b

(0)

on June 24, 2014
at 04:57 PM

A new study in the European Journal of Nutrition shows that oral glutathione supplements are available to the body and have a positive immune benefit.

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione.

http://www.ncbi.nlm.nih.gov/pubmed/24791752

an>

2
737f13eca77628ccd9af597e16edadaf

(20)

on August 09, 2012
at 03:09 PM

I've become a distributor for Max International after doing a heap of research. Not interested in a slugfest, I'll give you the guts of the science, and a bit of the background so you can do your own research and make up your own mind :)

MaxONE contains the ingredient D-Ribose-L-Cysteine, a cysteine pro-drug, which goes by the name RiboCeine. There is no glutathione in the products. As the others have stated whole glutathione supplements are practically worthless.

First and foremost the independent research, 20 published articles over the last 25 years, funded by the National Institutes of Health, the Veterans Administration and more: http://159326.max.com/max4u/pages/?wicket:bookmarkablePage=:com.max.web.page.RiboceinePage

I also recommend the patent, it's probably the best science overview of it, and references a number of the other published articles on it: http://www.google.com/patents/US20090042822?printsec=abstract#v=onepage&q&f=false

See Table 1 for the "300% more effective than NAC" claim. Note the 1.3x increase with NAC was a concentration 2.5 higher than the RiboCeine, which produced a 1.7x increase.

That kinda answers the question of "is there a cheaper no-name variety one should look at?" Not until the patent expires.

Also studies have shown RiboCeine supports GSH levels in the kidneys better than NAC http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2005.pto_96613.x/pdf

There is evidence in humans that administration of N-acetylcysteine will reverse or prevent acetaminophen-induced liver injury, but it does not always antagonize kidney injury (Davenport & Finn 1988). Unlike N-acetylcysteine, Ribose Cysteine is a cysteine prodrug that antagonized acetaminophen-induced target organ injury in both liver and kidney (Roberts et al. 1992; Lucas et al. 2000).

A little more background to support the "best thing since sliced bread" claim :P RiboCeine was created by Dr Herbert Nagasawa. A few career highlights:

  • Senior Editor of the Journal of Medicinal Chemistry for 32 years
  • Published over 165 papers in peer-reviewed journals
  • Ad hoc grant reviewer for the NCI and NIAAA, National Institutes of Health
  • Senior Career Research Scientist for the Veterans Administration
  • Creator of the new 3-minute cyanide antidote for the US Department of Defense

25 years ago he initially developed it for alcoholic Vietnam War vets to protect their liver while working at the Veterans Administration. He was onto glutathione long before before most, and as you can see not just in the role of GSH, but also the chemistry of increasing glutathione.

Dr Nagasawa actually missed the his first RiboCeine product launch event at Max International in 2010. He was at the National Institutes of Health-Homeland Security 4th Annual Countermeasures Against Chemical Threats Network Symposium to presenting his work on the cyanide antidote.

If you don't think Dr Nagasawa knows what he's doing when it comes to glutathione, then don't ask me cause I ain't got nothing compared him! :)

FYI the Cellgevity product (http://www.getmaxed.net/max-cellgevity) is the one to get now, not MaxONE. It has the same amount of RiboCeine plus 12 other ingredients, including a bunch which are known to be Nrf2 activators, which increases the various gluathione enzymes. That's a whole other interesting topic :)

As for my experience, I noticed something in a few days. Have friends and family on it who like what it does for them. Plenty of big name athletes and doctors using it (http://www.getmaxed.net/who-has-taken-cellgevity). Hope that gives you the info you're after.

2
A727956fa3f943057c4edb08ad9e864e

on March 10, 2011
at 11:05 AM

I concur with Paleo lover. Supplementary glutathione is useless. Best to get it from foods:

http://www.naturalhealthweb.com/articles/shah5.html

Seems to me like anything that's slightly toxic enough to produce a hormetic effect will boost glutathione, so tumeric etc.

Other than that, undenatured whey or raw egg yolks are good sources of raw materials for glutathione.

I head NAC supplementation can have untoward long term side-effects, this was touched on in this post:

http://evolutionarypsychiatry.blogspot.com/2011/03/problems-i-have-nac-for-that.html

"What are the downsides of NAC? I can think of two problems that might be biggies - first off, NAC is a mucolytic that thins mucus by cutting disulfide bonds. I suspect that might raise risks - one wouldn't want too little mucus. Mucus is important. Paul Jaminet mentions this issue and links a study here. Also, cutting disulfide bridges within the body is what that inflammatory baddie homocysteine is supposed to do, leading to crispy collagen and inelastic elastin in the arteries (which would possibly first show up as high blood pressure). "

1
96440612cf0fcf366bf5ad8f776fca84

(19413)

on January 12, 2015
at 03:10 PM

I know I'm replying to an acient thread, but, it turns out that there's new research that shows plain old glutathione does have some benefit and is absorbed, even the non-acetyl/liposomal versions: http://freetheanimal.com/2014/12/glutathione-supplementation-bioavailable.html

1
96440612cf0fcf366bf5ad8f776fca84

(19413)

on August 28, 2013
at 06:27 PM

You could also make your own in a liposomal form. I have, and I have seen some improvement when taking it, but it's not the holy grail.

The idea is to encapsulate the glutathione in a lecithin layer to help it pass digestion unharmed.

You'll need some glutathione - comes in powdered form, fairly expensive, some powdered lecithin, though you could use liquid if you can find it. Sadly the lecithin usually comes from soy, and GMO soy at that, there are non-GMO versions and sunflower lecithin (sadly pills only).

You'll also need an ultrasonic jewelery cleaner, and a blender, and some warm, water.

See the directions here: http://www.hawkeshealth.net/community/archive/index.php/t-6456.html

You'd blend the lecithin and warm water together, then add the glutathione, blend some more, then move the mixture to the ultrasonic jewelery cleaner, and buzz it up in there for 20 minutes or so.

I mix in some ascorbic acid powder (vitamin C) to protect the glutathione, plus this also makes it a liposomal vitamin C as well, so it provides its own benefits still.

D396b126240f584bc358e6e4fd84e9e3

(455)

on August 29, 2013
at 01:55 AM

Good tip and I've thought about doing this myself since both liposomal GSH and vitamin C are insanely expensive.

1
D3916637d6d039167b4ac25ea7d9d7eb

on August 28, 2013
at 05:43 AM

For a bioavailable form of Glutathione look for Acetyl Glutathione, in conjunction with N Acetyl Cysteine, R Alpha Lipoic Acid and Acetyl L Carnitine you can significantly raise Glutathione levels through supplementation. The simple answer is yes it is very beneficial to supplement Glutathione, but once again look for Acetyl Glutathione specifically, and if possible incorporate the above precursors to maximize levels, production and recycling of this master antioxidant.

56fa5f31142f8e886269ebcf45f4822b

(0)

on June 24, 2014
at 04:59 PM

There are no human studies on Acetyl Glutathione, only animal and studies supporting reduced glutathione are referenced. If you know of any please post the links, I would like to see them.

1
D4217939e230b4e167255e7720e5df9d

on October 24, 2012
at 07:22 PM

I use maxone. Adrenal issues, liver issues have been quite sick for a few years. Maxone is awesome!!!! I love it. My husband uses it for workouts. He stopped taking it for 3 days and said he couldn't live without it. My husband is 40 this weekend. And he actually is looking younger because of it!!! Maxone is not just any old glutathione suppliment. I've done the other amino acids. Did nothing. We are also paleo. Well I am, very strictly. My husbands not so strict. We love maxone!!!! We love paleo!!!!!

1
Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on August 09, 2012
at 04:18 PM

Raw Milk/Whey is one of the best sources of glutathione.

I haven't been able to find any independent research on the product. Plus most of the chatter on the net seems to be slugfests between skeptics vs those selling the stuff with little science backing up either view.

Links to research/your experience much appreciated.

Here is a great article from CMast on Glutathione:

http://www.westonaprice.org/blogs/2010/09/11/the-biochemical-magic-of-raw-milk-and-other-raw-foods-glutathione/

Also, by clicking the "Glutathione" tag on the right hand side of Chris's blog (The Daily Lipid)... you get several more articles that dig into some other great points about glutathione.

http://blog.cholesterol-and-health.com/search/label/Glutathione

1
6371f0ae0c075ded1b8cd30aafd4bf16

on March 10, 2011
at 05:53 AM

I work with many in the Filipino Culture and they say that Glutathione supplementation is big there. They say many people take it to turn their skin white but that it has some adverse side effects. I was sold a similar supplement and told it was the supplement of youth. It turned out to be expensive whey and creatine. I know you can get it naturally from a lot of the foods found in the paleo diet (coconut) and the it does have some anti aging effects, but like any nutrient in concentrated quantities it can become detrimental instead of beneficial.

0
955889350ac8cdbc9cba33ffd6cd1b78

on January 09, 2015
at 08:23 AM

Glutathione is certainly the "real deal". The latest study done on oral L-glutathione supplements proved it is an effective way to enhance the body's GSH levels, so it puts the absorption myth to bed.
I have been taking GSH Gold for a while now, it has the L-glutathione, but it also has the precursors, along with some other vitamins. I found their information page quite helpful, and it was cited which was refreshing, i'd recomend their What Is Glutathione page.
They would be my own personal suggestion, having tried a few others (I won't mention any names specifically), it is by far the best in terms of quality and quantity of ingredients. Good dosages at a fair price.

0
Medium avatar

on May 10, 2014
at 07:58 AM

Glutathione is a substance that is naturally produced in liver. It is present in meat, fruits and vegetables. Generally glutathione is supplemented or taken by mouth for treating and preventing heart disease, asthma, liver disease preventing aging and Parkinson’s disease. Healthcare providers give glutathione or preventing poisonous side effects of cancer treatment. These are some of the benefits. And supplementing them for any other reason is not a good idea.

96440612cf0fcf366bf5ad8f776fca84

(19413)

on May 10, 2014
at 01:16 PM

Except that glutathione is broken down during digestion, and must be liposomally coated or in another form (acetyl I believe), to make it past the gut lining intact. This is a key factor if you're going to supplement with it.

0
7a777966a2b7f30251c358b6fe35936f

on April 30, 2014
at 12:16 PM

Glutathione, or GSH, is a characteristically happening protein that secures each phone, tissue, and organ from lethal free radicals and maladies. The supplement holds three amino acids: glycine, glutamate (glutamic corrosive) and cysteine. Glutathione can help repair harmed cells brought about by anxiety, radiation, contamination, disease and an assembly of different sicknesses. Profiting your body with glutathione supplements increments levels of this commonly happening cancer prevention agent. While vitamins C and E are the most well known cell reinforcement supplements, in light of the fact that they kill free radicals, glutathione has the included profit of being an effective cancer prevention agent in light of the fact that glutathione exists inside the cell.

0
7e8c375b50a5e5e6717c3d5ab664f0ab

on April 30, 2014
at 11:43 AM

I have been taking meta switch for weight loss by max international. This product has the ribocine in it as well. I was injured in a car accident in 2005 and took 2 years to learn to walk again. I struggled with extreme pain for 9 years as my left leg was shattered with a bilateral spiral fracture to the femur and tibia. I have a well documented court case against the person who hit me, so lots of documentation to prove my claims. I also suffed from loss of sensation to my left hand due to nerve damage. Here is what has happens to me so far.

I have lost 35 lbs in 9 weeks, I am no longer taking any pain medication. There is feeling coming back to my left hand. ( very hypersensitive at the moment but I had no feeling before). I was prone to hypoglycaemic attacks and they have pretty much gone away. I am walking better, bending down better, I have more energy than I have in years. Oh and this one will get ya. NO HANG OVERS! Ya I put that one to the test. Drank my face off 4 night in a row. Taking the meta switch ( I am sure the cellgevity would have the same effect or better) before I drank. Each morning I woke up fresh as ever. No hangover.

I don't sell this stuff and I was a huge sceptic. But after seeing what it did to my friend who had a spinal injury. I decided to give it a try.

I still don't sell the stuff and I don't get any thing to benefit from making this claim but whatever this riboceine stuff is, IT WORKS!

You could not pry this from my now much stronger and very capable hands. I am 43 and I am Canadian

0
21a1a131a0674d12ef7cdfca8a192e1f

(50)

on January 29, 2014
at 12:21 AM

Liposomal Glutathione is great, but very expensive… The newest form of Glutathione, Acetyl-Glutathione is also worth checking out: http://www.herbspro.com/acetyl-glutathione-89416.html?utm_source=Googlebase&utm_medium=Feed&gclid=CJ2t3sGOorwCFSFo7AodZxEACA

0
170a34a6aa3ac084202037ae0e25289b

on January 28, 2014
at 09:48 PM

Taking a glutathione supplement or L-glutathione supplement is useless. However taking a glutathione supplement that offers the precursors as well as a bioavailable form of this antioxidant is extremely beneficial. These include N acetylcysteine, r-alpha lipoic acid, Acetyl glutathione as well as liposomal glutathione. Achieving adequate gsh levels through diet alone is next to impossible, making supplements a great way to achieve optimal health without visiting the doctor a few times a week for GSH injections.

http://glutathionepro.com/what-it-takes-to-be-the-best-glutathione-supplement

0
170a34a6aa3ac084202037ae0e25289b

on January 28, 2014
at 09:47 PM

Taking a glutathione supplement or L-glutathione supplement is useless. However taking a glutathione supplement that offers the precursors as well as a bioavailable form of this antioxidant is extremely beneficial. These include N acetylcysteine, r-alpha lipoic acid, Acetyl glutathione as well as liposomal glutathione. Achieving adequate gsh levels through diet alone is next to impossible, making supplements a great way to achieve optimal health without visiting the doctor a few times a week for GSH injections.

http://glutathionepro.com/what-it-takes-to-be-the-best-glutathione-supplement

0
99c253d1158f8ca6c1e2c19e255fc23e

(-30)

on December 30, 2013
at 12:31 PM

0
7147c5a67e8bf852b4a511085a239e09

on October 07, 2013
at 03:14 PM

"1,000 mg dose [of glutathione] increased GSH levels in many physiological compartments, while 250 mg dose increased GSH in whole blood." NK, natural killer, cells cytotoxicity were increased two fold as well. So the answer now is YES, oral glutathione supplementation DOES work! See: "Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation" in Experimental Biology 2013 (April 22, 2013).

0
405b79871417cdd21d29282fab1f22bb

on September 03, 2013
at 07:36 PM

This doesnt work. My mon was taking this suppliment but there is no improvement. Its just a waste of your money buyign this product.

0
Cae22751ad5696352356a6362371f5e0

on September 02, 2013
at 02:22 PM

If Glutathione is native to your body what would increase the production of it? Redox signaling molecules also native to you body has been scientifically proven to stimulate the production of Glutathione by over 500% Where can you buy a bottle of redox signaling molecules as a native to your body supplement. [edit: spam link removed]

0
34456cf7d8686d88de97fa1332b534a5

(0)

on May 03, 2013
at 08:15 AM

Has the FDA approved Glutathione supplements??? If so why hasn't big names in pharmaceuticals like AstaZeneca and Pfizer picked it up???

96440612cf0fcf366bf5ad8f776fca84

(19413)

on August 28, 2013
at 06:18 PM

Because it isn't a patented drug that they can exclusively sell. If it were, you'd see ads on TV for it every few hours like crazy, "ask your doctor." Glutathione is produced endogenously by everyone, provided we have the right precursors and are healthy. It's our master antioxidant.

56fa5f31142f8e886269ebcf45f4822b

(0)

on June 24, 2014
at 05:01 PM

Glutathione is an approved dietary supplement, not a drug. It is available from a variety of sources.

-1
Eea9f016b5ae9a2f2a190e8e01ec824c

(-14)

on April 22, 2016
at 04:00 PM

If you got to the max dot com website then click 'The Max Difference', then click the 'science' tab  you'll get a list of independant studies

Max now have a product called CellGevity, which is MaxOne with other great health items that are actively promoted here. 

Their products don't contain any glutathione, but boost it, which is completely different to other glutathione products on the market (which work as well as eating brocoli)

So the science is there, and PaleoLover must not be up to speed with what this product is, but that's cool, no-one knows all the products out there.

-1
Fa764249ef0f30075a695590add459e8

on January 16, 2013
at 05:38 PM

If you want the original formula that Dr. Robert Keller formulated go to [link removed]

Dr Kellers partners started their own company and its not a MLM company

There you will find the original "max" formula that the company was founded on. The ingredients are of higher quality and the price is a fraction of the MAX product ONLY $39.95.. Dr Kellers formula for vitamin in awesome too.

-2
99c253d1158f8ca6c1e2c19e255fc23e

(-30)

on December 30, 2013
at 12:36 PM

spam

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