I'm curious if anyone here has experience with the Gaba supplement. I have a low but abnormal titer of anti-GAD65 antibodies which can reduce the quantity of Gaba produced by the body. I saw a study recently on PubMed that Gabapentin reduced nighttime clenching with greater efficacy than mouthguards. Can anyone comment on whether it also reduced anxiety, stress, tension, etc successfully for them? I'm not ready to try Gabapentin yet so thought I'd give the supplement a shot. Thoughts?
asked bybalor123 (3747)
Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!
on October 28, 2012
at 04:34 AM
Yes, I would say that GABA has had a noticeable anxiolytic effect on me, however: GABA itself can't cross the blood brain barrier, so the bio-availability of GABA supplements is pretty low.
Picamilon is one of a couple supplements that I've seen called "designer B vitamins"; a traditional B vitamin (niacin, B3, in this case), coupled with another molecule that lets the whole of the structure penetrate the blood brain barrier.
After crossing, picamilon is hydrolyzed into GABA and niacin, the former of which should cause an anxiolytic response. Another bonus of this supplement is that niacin is a vasodilator, which also tend to have anxiolytic effects.
And on that note: magnesium, another vasodilator, has also shown efficacy at specifically reducing bruxism (clenching.) See here: http://www.is.wayne.edu/mnissani/bruxnet/ploctran.htm
Edit: It is also noteworthy that anything that messes with GABA receptors tends to come with withdrawal symptoms when one stops taking it. The severity is proportional to the degree you are altering them: benzos like Xanax have pretty serious withdrawals; Phenibut (a synthesized variant of GABA that also crosses the BBB) can have moderate symptoms; picamilon withdrawals aren't intolerable, but you may experience a rebound increase in anxiety for a few days after stopping. Just something to be cognizant of. Kava, valerian, chamomile, niacin, magnesium should help cut the edge on withdrawals, if need be.
on October 28, 2012
at 05:21 AM
GABA does not penetrate the blood-brain barrier; it is synthesized in the brain. It is synthesized from glutamate using the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate (the active form of vitamin b6)
Extracts from Centella asiatica (gotu kola) and Valeriana officinalis (valerian) stimulate GAD activity (synthesis of gaba)
So, to sum up that part, the amino glutamate, vitamin b6, and the herbs gotu kola and valarian will increase your synthesis. Valarian makes you sleepy though, so id probably go with gotu kola (unless your aiming to take something at night, in which can it might be perfect)
Lemon balm also inhibits the GABA uptake enzyme, which also increases the amount in circulation, in the same manner as prozac increase serotonin.
GABA orally itself, wont have any significant effect.
Also as pointed out picamilon is a viable precursor.