Does anyone know what the latest is on prenatal folate/folic acid supplementation? I was researching the topic on this site but it seems like the answer is still up in the air. I read the article by Chris Masterjohn but since then I have read people commenting that the body cannot convert folate to folic acid. Am I missing something? I have been supplementing with the solgar brand metafolin 800mcg but now wonder if this was the right thing to do?
asked bypaleopregnancy (0)
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on November 18, 2013
at 06:11 PM
You have it backwards. People with an MTHFR gene defect (around 50% of the population has at least one mutation) convert folic acid to methyfolate slower than normal. The reason for this is that there are I believe 4 steps to conovert folic acid to methyfolate and the MethyleneTetraHydroFolate Reductase (MTHFR) enzyme is required for the last step which is methylation.
The "metafolin" (5-MTHF or Methylfolate) that you're already taking is the form that is already usable by your body and does not require any conversion steps, so you're good.