0

votes

Prenatal Folate/Folic Acid Supplementation?

Answered on November 18, 2013
Created November 18, 2013 at 1:58 PM

Does anyone know what the latest is on prenatal folate/folic acid supplementation? I was researching the topic on this site but it seems like the answer is still up in the air. I read the article by Chris Masterjohn but since then I have read people commenting that the body cannot convert folate to folic acid. Am I missing something? I have been supplementing with the solgar brand metafolin 800mcg but now wonder if this was the right thing to do?

Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

2 Answers

0
A7b6c0fc47c8a39a50d5399d74f2c521

on November 18, 2013
at 06:11 PM

You have it backwards. People with an MTHFR gene defect (around 50% of the population has at least one mutation) convert folic acid to methyfolate slower than normal. The reason for this is that there are I believe 4 steps to conovert folic acid to methyfolate and the MethyleneTetraHydroFolate Reductase (MTHFR) enzyme is required for the last step which is methylation.

The "metafolin" (5-MTHF or Methylfolate) that you're already taking is the form that is already usable by your body and does not require any conversion steps, so you're good.

0
32f5749fa6cf7adbeb0b0b031ba82b46

(41747)

on November 18, 2013
at 06:11 PM

Yes, humans convert folate to tetrahydrofolate. But like most everything biological, efficiency and rate varies. Certainly that's no reason to discontinue supplementing.

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!