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Lipid Particle Size "Not Good"

Answered on August 19, 2014
Created February 27, 2012 at 9:04 PM

I don't have the actual numbers yet but the doc tells me my latest blood tests revealed a very high LDL and bad particle size. My CRP is also elevated. He wants me to start taking a statin (Crestor)

I had started Paleo, working out, and testosterone supplementation (yes, I need it) about 4 weeks before the test. My supplements include vits B-complex, C, D3, fish oil, krill oil and CoQ10.

I have lost about 10 pounds (I started at 190, I am 65 inches tall) and am putting on muscle. I'm very reluctant to go on the statin but if I don't I'm afraid he'll stop prescribing the testosterone.

Should I go on the Crestor until my levels come back into range? Is the spike due to cleansing effect Paleo and exercise has started to have on a fatty liver (and fat body!)? If I don't go on the Crestor and continue to diet and adhere to Paleo when should I hope for better results?

C56baa1b4f39839c018180bf63226f7d

(3499)

on February 27, 2012
at 11:06 PM

The part that wasn't stated in the post here that allowed that biased conclusion to be stated was that a similarly low percentage of CHD admissions had LDL below 70 (17.6%; 1.4% with HDL>60 as well). However, this needs to be compared to the population at large, and the bell curve of cholesterol levels in the same. I have yet to find these statistics, though.

Fb67dc30cead043d1d13ea503a3044dc

(3280)

on February 27, 2012
at 10:33 PM

In the conclusions, they say this: "These findings may provide further support for recent guideline revisions with even lower LDL goals." ...?

77877f762c40637911396daa19b53094

(78467)

on February 27, 2012
at 09:41 PM

Did you have blood work done before making the changes you made to know how things are trending? Maybe they are trending towards better results? I would avoid any the Crestor if at all possible. There are other doctors who will prescribe the testosterone if your blood work supports it.

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2 Answers

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11b7b7ba720a5cd43c74a0ef99a16adb

(3448)

on February 27, 2012
at 09:37 PM

UCLA did a study of study of people hospitalized for heart attacks. The result? 75% of heart attack patients had LOW LDL levels (below 130). People with high LDL levels (over 160) only had 7.1 percent of the heart attacks.

What percentage of heart attack patients had both high HDL (over 60) and high LDL (over 160)?

0.7%. zero point 7 percent. Only 7 out of every 1,000. That's pretty close to zero as you can get.

http://www.ahjonline.com/article/S0002-8703(08)00717-5/fulltext

IMHO, the particle size is much more important than the overall LDL level. Unfortunatly, most of the LDL lowering procedures/drugs/diets increase the incidence of the bad LDL (small, dense, pattern-B). So, even though you've got less overall LDL, you've got more of the small, dense LDL (which explains the results of the UCLA study).

Also, from what I've been reading, stains are never beneficial to females under any circumstances. Apparently the overall mortality rate for women increases significantly with stain use.

Fb67dc30cead043d1d13ea503a3044dc

(3280)

on February 27, 2012
at 10:33 PM

In the conclusions, they say this: "These findings may provide further support for recent guideline revisions with even lower LDL goals." ...?

C56baa1b4f39839c018180bf63226f7d

(3499)

on February 27, 2012
at 11:06 PM

The part that wasn't stated in the post here that allowed that biased conclusion to be stated was that a similarly low percentage of CHD admissions had LDL below 70 (17.6%; 1.4% with HDL>60 as well). However, this needs to be compared to the population at large, and the bell curve of cholesterol levels in the same. I have yet to find these statistics, though.

0
8949bf87b0e0aefcad10f29975e4fa2b

(8989)

on February 27, 2012
at 09:49 PM

You might want to test certain foods or habits and see if they are inflammatory for you. Have you been to the dentist recently?

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