Does the effect of melatonin reveal a snapshot of your own production?

Answered on April 29, 2013
Created March 31, 2013 at 12:59 PM

Pardon the super awkward wording of that question. Surprisingly, I am a native English speaker. I know there are other threads along the same subject, but I couldn't find an answer to this.

I very, very rarely turn to any sort of sleep aid unless I am desperate (maybe 2 or 3 times a year, tops). The last few times I took melatonin, I woke up very groggy and it immediately threw off my ability to fall asleep for the next few nights.

Last night I took some (same dosage, same bottle) because working from home has resulted in an extremely unhealthy sleep schedule for me and I just cannot get to bed at a normal hour. This time, I woke up very refreshed at a normal hour and feel full of energy.

My question: does this disparity demonstrate a fluctuation in my own melatonin production? Or, is it natural to have fluctuation in production so that I would have a different experience with melatonin this go round?

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2 Answers



on April 29, 2013
at 03:20 PM

I think we need someone to make a clean supplement that provides timed release melatonin at slightly ever increasing levels until it reaches a peak release, followed by a drop and decreased release. Sort of like a flat line going into a sharp sine peak, then drop back down to a flat line and then zero.

That's what matches our normal natural release of melatonin.

That won't work for those with high night time cortisol, but it would for anyone who is simply not producing enough due to aging. I find that the time release ones just provide a flat line release, and leaves me groggy in the morning, while the normal ones just provide a single peak as soon as you take them, and then I find myself waking up at 3am fully alert.

Perhaps a time release is ok if it also raises our peak, but it would mean the ones I use don't dissolve fast enough and maybe I should take them a lot earlier when I need them.

But, if I'm honest enough with myself, I do see a clear pattern that the days I don't sleep as well are the days I've had extra coffee or green/black tea, so the answer in my case is to ease up on the caffeine. :)



on March 31, 2013
at 02:39 PM

Here is an excerpt on melatonin:

Well, when a man or woman ages is like an instructive test case for us as clinicians. Peri and PM women have mental fog and fatigue and lowered energy and cant sleep well at all. Men with andropause have the same issues. This sounds eerily similar to what a diabetic faces every day of their life as well. Very few people have put these two syndromes together clinically, but PM women and men with andropause, are a microcosm of what a T2D faces daily. Let’s examine this link further.

All diabetics are leptin resistant and that implies their hormones are disordered by the very nature of the biologic process. Diabetics get this disorder from altered light cycles and excessive carbohydrates out of season. PM get this too on a smaller scale when their ovaries fail. These processes are commonly thought to happen in diabetics because of diet alone, but most of my readers now know about the temperature and light effects are far bigger issues than modern healthcare realizes. This is why I mentioned the medication Cycloset earlier. Cycloset was approved for diabetics in 2009, but few physicians even know about it, or how it works in our brain to reset the circadian clock once it has been fast forwarded by mismatches. It works on the brain to fix the circadian mismatch that light and carbs cause when they are used out of their normal cycles. We look for altered AM and PM cortisol levels on an adrenal stress index test for a clue this is happening. It eventually results in the brain by lowering the dopamine pathways centrally.

Cycloset actually raises your AM cortisol spike that we normally see in a normal humans. I covered this extensively in my August webinar for members on my site. It resets the cortisol/DHEA/melatonin axis of the hypothalamus. When the circadian cycle is off we usually see low melatonin levels. Low melatonin levels are consistent found in epithelial tumors. In modern humans all epithelial cancers rates are exploding. Maybe now you might realize why.

Melatonin is the third most important anti-oxidant in the human brain. When melatonin is lowered chronically for any reason, we see a sharp rise in epithelial cancers. Epithelial cancers have risen dramatically since 1924. When Cycloset was approved for use by the FDA in 2009, it validated all my empiric clinical observations of what really causes diabetes and cancer. I believe the environmental mismatches that have gone on for decades are the real etiology for the modern epidemics we are seeing explode in medicine. It is due to a modern human never facing a true winter, and never giving the brain the appropriate sunlight and sundown stimulus it needs to function optimally.

Prior to 1924, we never had to worry about artificial light much. If you look at the incidence and prevalence of T2D and cancer since 1924, be prepared to be astounded out what I just laid out here. Diabetes and cancer may not be a disease after all. I said this earlier in the year in the Cold Thermogenesis series. They maybe an epigenetic phenomena of modern life!

This was from here. http://www.jackkruse.com/brain-gut-11-is-technology-your-achilles-heel/

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