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D3 supplement-timing and sleep (and/or circadian) studies, are there any?

Answered on August 19, 2014
Created March 14, 2012 at 1:30 AM

There have been quite a few questions/posts around the web on the best time of the day to supplement with Vitamin D3 with regards to improving sleep (or at least not disturbing sleep).
Most views seems to be based on experience and/or conjecture.

Does anyone know if there have been any actual studies carried out, in this area?

(please provide links/refs....)

Df6dabaf4b1ef3d5db980ad64c501a5b

on March 15, 2012
at 02:09 PM

I think that if you're already vitamin D replete you should probably tone down the supplementation. Vitamin D production in the skin is downregulated once it reaches a natural equilibrium while supplements don't have the same limiting mechanism. Going overboard could likely have negative effects.

543a65b3004bf5a51974fbdd60d666bb

(4493)

on March 15, 2012
at 03:08 AM

thx alwayscurious. with the second link, that patient was very, very Vit D deficient. their serum 25OHD was measured at just 5.9 ng/mL. which seems to ring true for problematic sleep (the low Vit D). I wonder if supplement timing effects on sleep depend on (or vary with) a persons Vit D levels (Vit D stores). eg. may be if you are Vit D replete, timing does not matter. But if you are deficient, taking D3 before bed may have more of an impact on your body & disturb sleep. While in a replete person, taking D3 before bed may even have the opposite effect & improve sleep. just speculation...

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Df6dabaf4b1ef3d5db980ad64c501a5b

on March 14, 2012
at 12:45 PM

I think most of the opinions out there on morning/evening D3 are simply n=1 experiences, including some on previous paleohacks threads:

http://paleohacks.com/questions/98166/vitamin-d-morning-seth-roberts-versus-night-robb-wolf#axzz1p5sR3YRh

I did manage to find two studies on resolving sleep problems by correcting vitamin D deficiencies via supplementation:

The first study isn't of much help - the abstract only indicates vitamin D is provided over 3 months, no mention of doses or timing. Resolving the vitamin D deficiency helped improve sleep in this study. http://www.ncbi.nlm.nih.gov/pubmed/22372707

The second study is notable here because sleep improved substantially on a large vitamin D supplement (50,000 IU) provided only once per week, suggesting that time of day may not be relevant. That being said, this is a report on a single patient, albeit in a clinical environment. http://www.ncbi.nlm.nih.gov/pubmed/21206551

Df6dabaf4b1ef3d5db980ad64c501a5b

on March 15, 2012
at 02:09 PM

I think that if you're already vitamin D replete you should probably tone down the supplementation. Vitamin D production in the skin is downregulated once it reaches a natural equilibrium while supplements don't have the same limiting mechanism. Going overboard could likely have negative effects.

543a65b3004bf5a51974fbdd60d666bb

(4493)

on March 15, 2012
at 03:08 AM

thx alwayscurious. with the second link, that patient was very, very Vit D deficient. their serum 25OHD was measured at just 5.9 ng/mL. which seems to ring true for problematic sleep (the low Vit D). I wonder if supplement timing effects on sleep depend on (or vary with) a persons Vit D levels (Vit D stores). eg. may be if you are Vit D replete, timing does not matter. But if you are deficient, taking D3 before bed may have more of an impact on your body & disturb sleep. While in a replete person, taking D3 before bed may even have the opposite effect & improve sleep. just speculation...

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