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If you could fund one scientific study what would it be?

Answered on September 12, 2014
Created September 04, 2011 at 7:25 PM

If you could fund one scientific study what would it be? What type of study do you expect to yield the most useful results?

6869a1f2294b3a717a53645589a91d18

(1689)

on September 04, 2011
at 11:09 PM

http://www.ncbi.nlm.nih.gov/pubmed/2081920 http://www.ncbi.nlm.nih.gov/pubmed/7790697 http://www.biomedcentral.com/1471-2407/8/122 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408928 http://cancerci.com/content/9/1/14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001676/pdf/brjcancer00506-0050.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845135 http://www.communityoncology.net/journal/articles/0501022.pdf http://www.nutritionandmetabolism.com/content/pdf/1743-7075-7-7.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001676/pdf/brjcancer00506-0050.pdf

6869a1f2294b3a717a53645589a91d18

(1689)

on September 04, 2011
at 11:09 PM

Here are some K2/cancer studies http://jama.ama-assn.org/cgi/content/full/292/3/358 http://www.ncbi.nlm.nih.gov/pubmed/16400650 http://www.ncbi.nlm.nih.gov/pubmed/19501932 http://www.ncbi.nlm.nih.gov/pubmed/17376044 http://www.ncbi.nlm.nih.gov/pubmed/17399847 http://www.ncbi.nlm.nih.gov/pubmed/19639210 http://www.ncbi.nlm.nih.gov/pubmed/19092277 http://www.thorne.com/altmedrev/.fulltext/8/3/303.pdf Here are some keto/cancer studies http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819381 http://www.ncbi.nlm.nih.gov/pubmed/2736199 http://www.ncbi.nlm.nih.gov/pubmed/20009300 http://www.ncbi.nlm.nih.

A727956fa3f943057c4edb08ad9e864e

(4183)

on September 04, 2011
at 08:53 PM

What are your outcome measures? Most metabolic damage is long term, bit too expensive, but we can dream eh? :)

C1c86f42410cd4788bd9c5cf801dcd8f

(2246)

on September 04, 2011
at 07:58 PM

This is a great question.

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12 Answers

4
A089b683ee0498f2b21b7edfa300e405

on September 04, 2011
at 09:13 PM

All the studies they did on rats, with fake food.. done on real humans with real food..!!

3
Bbaeb252415d6123214e1b98c17117ac

(414)

on September 05, 2011
at 03:05 PM

Abstract

The paleolithic diet provides health benefits and increases longevity compared to USDA dietary guidelines diet.

Introduction

Human nutrition researchers are increasingly exploring the role evolution has played in the development of modern human physiology and are becoming aware of various nutritionally related disorders in Western societies that are not observed in a number of modern hunter-gatherer populations

Methods

This was a clinically controlled study, where the food intake by the participants was monitored at all times. Two groups of volunteers participated in the study. The "USDA" group was fed the diet recommended by the USDA - 6 portions of grains per day, blah blah. The "Paleo" group was fed according to the principles of the paleo diet - absolutely no food was used that was not available to Homo Sapiens 20,000 years ago or earlier. The study was conducted over the duration of 70 years. All other conditions were strictly the same for both groups.

Results

Only 52% of the "USDA" group completed the study. The remaining 48% have died from the following causes: Chronic heart disease, 22%. Diabetes: 12%. Other causes: 14%. Of the "Paleo" group, 95% completed the study, all of them in good health. The remaining 5% have died from the following causes: quietly in their sleep, 5%

Discussion

The Paleo diet was determined to be 2134% superior to the USDA recommended died (alpha 0.05, beta 0.1).

Conclusion

The New USDA Dietary Guidelines: Total Hogwash

References

This does not count towards my GPA, so I'll skip this section.

2
A727956fa3f943057c4edb08ad9e864e

on September 04, 2011
at 08:25 PM

I have tonnes of ideas for studies, my dream would be to have my own food company selling traditional foods in order to fund nutrition research.

  1. Magnesium in the prevention of gestational diabetes.
  2. Glycine in the aftermath of stroke, there's already one small study but I can't find any bigger follow-ups
  3. Coconut oil for alzheimer's, all I've seen so far is one case report
  4. Vitamin D for autism, I expect I won't be waiting too long for that one.
  5. K2 for the treatment of cancer
  6. A properly powered study in the treatment of cancer with a clean keto diet. Have you seen the processed crap they are feeding people as part of the ReCHARGE study? Ugh.

I could go on and on, I get about 3 ideas for studies a day, I work in research but unfortunately not qualified to be a PI yet.

6869a1f2294b3a717a53645589a91d18

(1689)

on September 04, 2011
at 11:09 PM

http://www.ncbi.nlm.nih.gov/pubmed/2081920 http://www.ncbi.nlm.nih.gov/pubmed/7790697 http://www.biomedcentral.com/1471-2407/8/122 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408928 http://cancerci.com/content/9/1/14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001676/pdf/brjcancer00506-0050.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845135 http://www.communityoncology.net/journal/articles/0501022.pdf http://www.nutritionandmetabolism.com/content/pdf/1743-7075-7-7.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001676/pdf/brjcancer00506-0050.pdf

6869a1f2294b3a717a53645589a91d18

(1689)

on September 04, 2011
at 11:09 PM

Here are some K2/cancer studies http://jama.ama-assn.org/cgi/content/full/292/3/358 http://www.ncbi.nlm.nih.gov/pubmed/16400650 http://www.ncbi.nlm.nih.gov/pubmed/19501932 http://www.ncbi.nlm.nih.gov/pubmed/17376044 http://www.ncbi.nlm.nih.gov/pubmed/17399847 http://www.ncbi.nlm.nih.gov/pubmed/19639210 http://www.ncbi.nlm.nih.gov/pubmed/19092277 http://www.thorne.com/altmedrev/.fulltext/8/3/303.pdf Here are some keto/cancer studies http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819381 http://www.ncbi.nlm.nih.gov/pubmed/2736199 http://www.ncbi.nlm.nih.gov/pubmed/20009300 http://www.ncbi.nlm.nih.

1
7c9f81d68c78de1a31eab9c91c17b4b8

on September 05, 2011
at 05:23 PM

I would be interested in the effect of food on alzeimer's, ADHD and autism, hyperactivity in children, depression...anything that has to do with the gut/brain connection.

If I had billions of dollars I would pay for it. As it stands now I can donate about $25. Who else can chip in?

1
396679d1e1357eb7e9397ca34c8773ea

on September 05, 2011
at 12:32 AM

I know Gary Taubes already hit it up in GCBC but I would love to see a study that definitively researched the link between cholesterol and heart disease. It would be an official N=1 Fat=Good for the entire US. No more explaining how I stay fit on a high fat diet.

1
5e6a6f5c0fd3ab048f81c0a500206f41

on September 04, 2011
at 11:42 PM

great question! i am actually about to start my grad degree in nutrition and want to focus my thesis on some aspect of the paleo diet. i am very curious to see how people answer this question!

1
Ce41c230e8c2a4295db31aec3ef4b2ab

(32564)

on September 04, 2011
at 09:24 PM

Definitely Vitamin D and autism.

1
D10ca8d11301c2f4993ac2279ce4b930

(5242)

on September 04, 2011
at 08:11 PM

Metabolic ward: Moderate PUFA low fructose, Moderate Fructose low pufa, Moderate PUFA & Fructose, low PUFA & Fructose, Low PUFA & no Fructose. Overall carbohydrate, fat, and protein controlled for.

A727956fa3f943057c4edb08ad9e864e

(4183)

on September 04, 2011
at 08:53 PM

What are your outcome measures? Most metabolic damage is long term, bit too expensive, but we can dream eh? :)

1
584b19d2b6cebc7cdf070b5f8a5a7937

(369)

on September 04, 2011
at 08:02 PM

What a great question. I want to conduct a study on paleo-raised vs SAD-raised children. It is astounding how many people deal with disorders that seem to be preventable by living thoughtfully and responsibly. The number of people who pop pills for mood/anxiety/learning disorders still shocks me every time I think about it. I work in mental health (Autism mostly), and after reading Primal Body, Primal Mind by Nora Gedgaudus, I am so cued in to this topic. I would hypothesize that significantly fewer cases of developmental disorders, mood disorders and mental disorders (and disease in general OF COURSE) would occur in the paleo group than in the SAD group. I would also like track the lineage data in this study- parents' diets. Since what we put in and on our bodies affects how our genes are expressed, this should yield interesting results too.

This concept is just common sense and simple, but I am interested to get these solid numbers. Something similar may be out there that I haven't found yet.. Of course, my future kid will be my own case study, but I know it will be too hard to remain objective and unbiased. :)

0
F5a8a14fc6a4d33c2563d0dd3066698a

(714)

on September 05, 2011
at 03:58 PM

Evgeny hit on it, but basically we need a version of Framingham for dietary options.

Low fat, high carb vs. Paleo vs. SAD

You subsidize the participants, find some highly technical and invasive mechanism to eliminate confounders having to do with reporting and physical activity, and subsidize the grocery tabs such that the per capita expense for each cohort is the same.

End points would be incidence of heart disease, diabetes, stroke, and cancer. Also, at inception each potential participant would be able to select into which cohort he or she would be placed, helping eliminate additional confounders having to do with adherence.

Some of the more technical suggestions would be fascinating, and are far more likely to get funded, but I personally think one of the problems with dietary research is the predilection of scientists to research nutrients rather than food, if you get what I'm saying. People don't eat monounsaturated fat, carbs, and NaCl. They eat olive oil, bread, and canned soup.

0
3846a3b61bc9051e4baebdef62e58c52

(18635)

on September 05, 2011
at 03:09 PM

Wellness/holistic health vs. standard medical intervention on a large scale. I have heard it stated that up to 95% of all disease and illness is likely due to lifestyle. Would be interesting to see what percentage it is without question. A study like this not only has funding issues obviously, but this is my imaginary study so :P.

Study focus on morbidity, mortality, and parameters of optimal function and not just the absence of symptoms with our current level of other technologies.

0
22e9f1dabb279c620977403789aef7dd

(160)

on September 05, 2011
at 02:45 AM

Too long term, but seeing the current state of some of the elderly population, I am wondering if there is a link to Liver/Bone Marrow consumption (or lack thereof) and occurrence of Alzheimer's.

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