3

votes

Should I supplement resveratrol?

Answered on September 12, 2014
Created March 21, 2011 at 10:01 PM

I hope I spelled that correctly. I am 49 years old, paleo about 3 mos now, working on bodyfat loss and general good health. I workout about 4 days a week with bodyweight exercises and sprints, plus general good activity the rest of the week. So, back to my question--I can't drink alcohol, so wine is out. Should I supplement with resveratrol? Any specific brands to recommend? Thanks.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 23, 2011
at 02:43 PM

@Ipso This is a very fair critique. But if you read the totality of the data and research being done the good outweighs the bad in a biologic system. When you are a researcher you need to use that skeptic an eye.....when you are a doctor you must use that same eye and the other one needs to assess the clinical effect emperically. The third eye intuition dictates action and future questions to research. That is how I view it today. I am not dogmatic on resveratrol and have an open mind.......but right now use make more sense than not.

81a52efad6effda9eff3a3dcbc5f0ec6

(47)

on October 23, 2011
at 06:38 AM

Sinclair also kind of showed that the isolated resveratrol doesn't seem to quite work the way of those dry French red wines -- the reason being you need those other ingredients form the wine acting in cahoots with the reseveratrol to be effective. My impression is that taking reseveratrol is kind of like taking calcium: it doesn't quite work the way you intended, as it works in concert with ingredients that are mutually dependent on one another.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 23, 2011
at 04:23 AM

David Sinclair's lab at Harvard show the upper limits for humans is over 250,000 mgs a day. The toxic dose is quite high apparently. For me I base the needs on my own lab testing. I have not talked here or on my blog about my circadian rhythmn theories and aging and metabolism but resveratrol dosing is tied to this. This is why when we go to low light situations I dial up the dose but in long light conditions I dial it down. It has to due with HS CRP and Vitamin D levels. PQQ also plays a role in FOXO activation and resveratrol may be antagonistic to this. So one has to pay attn to this

Medium avatar

(8239)

on October 22, 2011
at 10:33 PM

Jack, your overview of the data is terrific. I'm familiar with individuals with Parkinson's-like symptoms, who are doing mega doses of resveratrol. I'm assuming that what constitutes upper threshold dosage depends on factors like" whether the goal is reparative or preventive. With that in mind, what degree of supplementation do you consider appropriate for a healthy person (mid-50s) whose goal is (healthy longevity)? How did you hit upon your 4g daily dosage? What factors did/do you weigh?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 22, 2011
at 09:03 PM

Plus ome.......

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 22, 2011
at 09:03 PM

Resveratrol dosing for me during low light months goes even higher.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 22, 2011
at 09:02 PM

Quercetin is my go to anti histamine too. I use a mixture with high dose vitamin c when i need it

2b2c2e4aa87e9aa4c99cae48e980f70d

(1059)

on October 22, 2011
at 07:26 PM

Dr. K's Top Paleo Supplements: http://jackkruse.com/what-are-the-top-ten-paleo-supplements/

E0965e067b72ea7a45d6fad6f164e132

(229)

on March 25, 2011
at 03:10 AM

Hey I believe in whole real foods rather than supplements, but I could be wrong.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 04:52 PM

The point is you cant get enough of it from foods. The rest of the bioactive polyphenols all come in paleo foods. I understand that everyone thinks they should just eat whole foods. I just think that is good.....not optimal. That is the point.

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 23, 2011
at 04:33 PM

my granddad drinks wine like a fish. (what does that even mean anyway). He's just about to turn 80, is stong as on Ox, and appears as most 60 year olds do. But I'm still on the fence about supping RES separately from foods. I understand it has positive effects, but I drink some green tea with EGCG, take a spoon of raw cacao powder every now and then, and have a glass of red wine every now and then. do you think it's good to ALSO take a daily dose of concentrated RES? It just seems strange if we really need to do that, especially considering some the points that Stephan G brought to the table.

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 23, 2011
at 10:02 AM

just stumbled over this new one by biotivia: seems to be the state of the art with regard to stilbenes synergy in one supplement: "By combining the three principal analogs of resveratrol we have created a hugely potent full spectrum stilbene formulation" http://www.biotivia.com/pteromax/whatispteromax.html

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 23, 2011
at 09:59 AM

just stumbled over this new one by biotivia: seems to be the state of the art with regard to stilbenes synergy in one supplement: "By combining the three principal analogs of resveratrol we have created a hugely potent full spectrum stilbene formulation" http://www.biotivia.com/pteromax.html

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 09:45 AM

That and quercetin. Quercetin is another interesting polyphenol

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 23, 2011
at 08:43 AM

how about combinig resveratrol with pterostilbene? http://www.lef.org/magazine/mag2009/ss2009_The-Other-Resveratrol_01.htm

06d21b99c58283ce575e36c4ecd4a458

(9948)

on March 23, 2011
at 06:48 AM

Looking forward to your post on the 15 other factors for longevity on Paul Jaminet's blog http://perfecthealthdiet.com/

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 02:20 AM

here it come Andrew......read below.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 02:02 AM

Do you need it? No but it is a longevity levee to help you expand a haelthy life. Jack my belief is that there are 15-20 major biological angles to longevity. Paleo plays a role in about 5 of them. Its very important. But the other 15 count too. To discount them to me.....is a bad move. But remember for me the end game is healthy longevity and outliving my cohort. Medicine is both an art and science. What I advocate is meshing what we know is the best scientific evidence and what are the most likely new frontiers that research is moving too.....and then marrying them. That is my paleo

D10ca8d11301c2f4993ac2279ce4b930

(5242)

on March 22, 2011
at 08:22 PM

Looking forward to it, Dr. K.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 04:51 PM

I don't and when I get home I will post here why! Lots of juicy stuff. This is my particular area of interest. Now I have to go see patients

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 04:24 PM

you're talking drinking wine? if so, that's pretty funny Ig. that's the type of supp I like.

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 04:23 PM

vote to delete this. it was supposed to fall under Ignacio's answer as a comment.

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 04:09 PM

Resveratrol may indeed do all of these things you say here Doc. I wouldn't *necessarily* argue against it. However, I would question whether or not it's needed, based on the fact that you cannot eat enough to obtain the supplemental doses that you are advocating. What about just getting the polyphenols from foods and a bit of red wine here and there?

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 03:27 PM

this is the best source for an answer here. i agree with this.

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 22, 2011
at 02:15 PM

@Dr.K 4g a day is rather impressive.. do you also notice an immediate effect (e.g. increased training tolerance), or do you purely take it for the long term benefits? what else do you take on a daily basis for optimizing health and performance if i may ask?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 01:04 PM

You my frined have not stayed up with research. That was true maybe 5 yrs ago. NIH has resveratrol in a clinical trial now on type 2 diabetics. Early results have been all world. And it increase rhBMP2 in HUMANS! And I use synthetic BMP2 in spine surgery alot it cost 4000 a pop. I stopped using it and now get my patients on resveratrol.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 01:02 PM

Good....but optimal is better. Do you knowin one entire bottle of wine there is only about a mg of resveratrol. So start drinking! Resveratrol is not found in high enough quantities in any food therefore it must be supplemented to get SIRT1 and MTor effects. Read the Longevity Factor. Written by one of my collegues. Great book

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 01:00 PM

i did it with an S.....sticky keys! I sent another.

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 22, 2011
at 06:24 AM

Also -- paleohackS.com (with s)

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 22, 2011
at 06:10 AM

Fixed. (sorry about that) please try me again.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 03:17 AM

Patrik I tried to email you at [email protected] but it said your box was full?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 02:51 AM

In a recent study from the American Journal of Clinical Nutrition , resveratrol was shown to: inhibit preadipocyte proliferation inhibits preadipocytes' maturation into mature adipocytes stimulates glucose uptake inhibits de novo lipogenesis cause a down regulation of the inflammatory cytokines IL-6, TNF-alpha, NF-kB, and IL-8 (IL-8 is proatherogenic- enhances CAD) Resveratrol increases production of rhBMP2 to increase bone mass.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 02:51 AM

Resveratrol decreases fat storage decreased insulin secretion decrease glycolysis in the liver neuro and cardiac protection increased insulin sensitivity increased cell survival decreased cell death increased resistance to stress like ROS

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 02:41 AM

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 22, 2011
at 01:59 AM

@Dr. K - I sent you an email but it bounced. How can I email you?

  • Aebee51dc2b93b209980a89fa4a70c1e

    asked by

    (1982)
  • Views
    3K
  • Last Activity
    1256D AGO
Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

12 Answers

9
93b2e3c143c962cf8c92e6316a483ddf

(150)

on March 22, 2011
at 02:18 PM

Stephan Guyenet has an interesting post on polyphenols and addresses resveratol: Polyphenols, hormesis & disease, part 2

He summarizes with this statement: Supplementing with polyphenols and other plant chemicals in amounts that would not be achievable by eating food is probably not a good idea.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 04:51 PM

I don't and when I get home I will post here why! Lots of juicy stuff. This is my particular area of interest. Now I have to go see patients

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 03:27 PM

this is the best source for an answer here. i agree with this.

D10ca8d11301c2f4993ac2279ce4b930

(5242)

on March 22, 2011
at 08:22 PM

Looking forward to it, Dr. K.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 02:20 AM

here it come Andrew......read below.

4
D10ca8d11301c2f4993ac2279ce4b930

(5242)

on March 22, 2011
at 02:23 AM

I'm not yet convinced that it's worthwhile. There's worry that the mechanisms by which antioxdiants work aren't well enough understood and that they may function by way of hormesis which means that mega-dosing could be a way of poisoning yourself. I honestly haven't looked into it that much but the word on the street is to wait for further testing.

3
Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 02:55 AM

Resveratrol. One master activator of antioxidant and anticancer genes appears to be Nuclear factor-erythroid-2-related factor 2 (Nrf2). It also is the only know activator of the SIRT 1 path besides calorie restriction(demonstrated in the 1930 Cornell experiments). The sequence of events involved in phytochemical chemoprevention mediated by Nrf2 is complex and is summarized in the 2008 publication. http://www.ncbi.nlm.nih.gov/pubmed/18937164?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed

Bromelain, ginger, curcumin, aswagandah and boswellia and RESVERATROL are in this category. RES also activates SIRT1 as I mentioned. It also acts on MTor. These are three extremely important anti aging longevity pathways. Resveratol is the only known compound to act upon all three. Not only that resveratol effects are found in almost all animals and is highly conserved by evolution? Still think its worthless and un paleo? It infact pre dates paleo by hundreds of millions of years....like billions. All the way back to Yeast. 2.7 billion yrs by latest estimate of the Human genome project.

Back in the 1930s, health effects of red wine only existed in oral folk medicine and folk writings.

circa 2005 Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro, Effect of resveratrol on proliferation and telomerase activity of human colon cancer cells in vitro, Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms in vivo, Immortalization of epithelial progenitor cells mediated by resveratrol, As mentioned previously, resvertrol, another powerful inhibitor of NF-kappaB activation, is also effective against osteoporosis,through induction of bone morphogenetic protein-2 in humans.

Resveratrol has been shown to be a potent activator of HERT and rHERT. Experiments have been done activating HERT (the catalytic component of telomerase) for certain stem cell survival chain cell types. For example by transfecting hTERT DNA into primary human marrow mesenchymal stem cells, those cells can be immortalized and induced to differentiate into chondrocytes. So we can now protect cartilage joints with it. We have recently demonstrated that overexpression of human telomerase reverse transcriptase (hTERT) in hMSC (human mesenchymal stem cells) reconstitutes telomerase activity and extends life span of the cells studied. Take a look in cancer lines of the marrow.....http://cancerres.aacrjournals.org/content/65/21/9943.abstract

It has done this in hair cell lines, Bone lines, neuroblasts, micro glia, kidney, pancreas, liver and cardiac muscle lines. It has amazing effects on platlets by making them less sticky and improving laminar flow in vivo and has also been shown to be the most potent activator of Nitric Oxide synthetase to increase intra arterial NO to vasodilate blood vessels. It can reverse senescent cell lines by increasing mitochondrial biogenesis.....mechanism still being worked out.

I strongly recommend any one and every one to read the story of resveratrol and it massive effects in the book called the Longevity factor. I follow published resveratrol research via pub med and NIH and medscape weekly. It is the one polyphenol that is worth it in my estimation. Tumeric is a close second and them comes ECCG of green tea....and of course 100% pure cacoa. I put in my coffee and bottled water daily. The data is becoming overwhelming. Pluripotency of these substances is more the rule than the exception. A few decades back Vitamin D was seen to be useful mainly for bone maintenance for those deprived of sunlight. The medical establishment sternly warned that any daily dose over 400iu could be seriously toxic. It was not thought of in terms of cancer prevention. Today there are over 80 population and laboratory studies indicating that vitamin D can reduce incidences of and mortality due to multiple kinds of cancer with reductions of 50% or more in some cases. I am not saying resveratrol is for everyone but I think you need to really look at the data if your interested in being healthy fit and old.

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 23, 2011
at 08:43 AM

how about combinig resveratrol with pterostilbene? http://www.lef.org/magazine/mag2009/ss2009_The-Other-Resveratrol_01.htm

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 09:45 AM

That and quercetin. Quercetin is another interesting polyphenol

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 04:52 PM

The point is you cant get enough of it from foods. The rest of the bioactive polyphenols all come in paleo foods. I understand that everyone thinks they should just eat whole foods. I just think that is good.....not optimal. That is the point.

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 23, 2011
at 10:02 AM

just stumbled over this new one by biotivia: seems to be the state of the art with regard to stilbenes synergy in one supplement: "By combining the three principal analogs of resveratrol we have created a hugely potent full spectrum stilbene formulation" http://www.biotivia.com/pteromax/whatispteromax.html

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 23, 2011
at 09:59 AM

just stumbled over this new one by biotivia: seems to be the state of the art with regard to stilbenes synergy in one supplement: "By combining the three principal analogs of resveratrol we have created a hugely potent full spectrum stilbene formulation" http://www.biotivia.com/pteromax.html

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 23, 2011
at 04:33 PM

my granddad drinks wine like a fish. (what does that even mean anyway). He's just about to turn 80, is stong as on Ox, and appears as most 60 year olds do. But I'm still on the fence about supping RES separately from foods. I understand it has positive effects, but I drink some green tea with EGCG, take a spoon of raw cacao powder every now and then, and have a glass of red wine every now and then. do you think it's good to ALSO take a daily dose of concentrated RES? It just seems strange if we really need to do that, especially considering some the points that Stephan G brought to the table.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 22, 2011
at 09:02 PM

Quercetin is my go to anti histamine too. I use a mixture with high dose vitamin c when i need it

3
Ac1e55cf06c2180f4008ff01953d10dd

on March 22, 2011
at 04:20 PM

I supplement with Merlot and Cabernet most days. It is really good, I prefer the Argentine and French brands. I am not sure, though whether I am reaching optimum level.

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 04:24 PM

you're talking drinking wine? if so, that's pretty funny Ig. that's the type of supp I like.

1
Cc69a51b427eaad36251cce9dcca4d3a

(1074)

on October 22, 2011
at 07:19 PM

i crack open Resveratrol pills and inhale them, jk. no but I put them on my tongue for a min though

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 22, 2011
at 09:03 PM

Plus ome.......

1
4781cf8ae1bfcb558dfb056af17bea94

(4359)

on March 22, 2011
at 12:32 PM

It doesn't even work in mice so I don't think it works in humans... Only helped prevent heart attacks in mice, as do many polyphenols... In my view, it's just another polyphenol, in an unsually concentrated dose.... Gets metabolised very quicly in human serum.... not worth the $$ and the risks...

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 01:04 PM

You my frined have not stayed up with research. That was true maybe 5 yrs ago. NIH has resveratrol in a clinical trial now on type 2 diabetics. Early results have been all world. And it increase rhBMP2 in HUMANS! And I use synthetic BMP2 in spine surgery alot it cost 4000 a pop. I stopped using it and now get my patients on resveratrol.

1
5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 22, 2011
at 07:32 AM

my approach with supplements is the same as with everything else in nutrition: do you look, feel, or perform better when taking it? i take about 10 different supplements every day, exactly because i can answer this question for each one with a clear "yes". resveratrol is one of them. in my experience it takes at least 250mg to notice a difference (for example, before an intense workout). having said that, there is always a certain remaining risk for taking a supplement that is rel. new and not yet completely understood (like many others), and every individual may react to the same supplement slightly differently. so, best to do some research and reading, then try it out, observe, and then decide if you wanna keep it.

0
56c28e3654d4dd8a8abdb2c1f525202e

(1822)

on July 24, 2013
at 02:23 AM

I far prefer to supplement with Concord grapes, but those are available only two months a year. Two things about supplementing with wine,

1) I really detest sulfites (and who knows what else they put in commercial wines),

2) wines from California or Argentine will have pitiful amounts of resveratrol, and that is because resveratrol is produced as an anti-fungal by the plant. Yes, you are still getting your anthocyanines, specially in winter it is difficult to get them in other ways. The cooler, moister the weather, the higher the resveratrol. Hybrid grapes have more than vitis vinifera.

I make my own wine, in Michigan, and use 50% local grapes (and 50% grapes from CA). Local grapes are in fact all hybrids, and make a red wine that is in fact rather dark, so presumably rich in both resveratrol and anthocyanines. If you can get hybrid grapes wine give it a try.

0
Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 04:22 PM

you're talking drinking wine? if so, that's pretty funny Ig. that's the type of supp I like.

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 04:23 PM

vote to delete this. it was supposed to fall under Ignacio's answer as a comment.

0
E0965e067b72ea7a45d6fad6f164e132

on March 22, 2011
at 04:55 AM

I supplement myself with good Red French Wines, but taking a pill no.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 01:02 PM

Good....but optimal is better. Do you knowin one entire bottle of wine there is only about a mg of resveratrol. So start drinking! Resveratrol is not found in high enough quantities in any food therefore it must be supplemented to get SIRT1 and MTor effects. Read the Longevity Factor. Written by one of my collegues. Great book

E0965e067b72ea7a45d6fad6f164e132

(229)

on March 25, 2011
at 03:10 AM

Hey I believe in whole real foods rather than supplements, but I could be wrong.

0
Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 01:21 AM

in my view absolutely. Biotivia trans max 500 or RevGenetics are brands that have checked out with consumerlabs.com. I use both. 4000 mgs a day for me!

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 22, 2011
at 01:59 AM

@Dr. K - I sent you an email but it bounced. How can I email you?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 03:17 AM

Patrik I tried to email you at [email protected] but it said your box was full?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 02:51 AM

Resveratrol decreases fat storage decreased insulin secretion decrease glycolysis in the liver neuro and cardiac protection increased insulin sensitivity increased cell survival decreased cell death increased resistance to stress like ROS

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 23, 2011
at 02:02 AM

Do you need it? No but it is a longevity levee to help you expand a haelthy life. Jack my belief is that there are 15-20 major biological angles to longevity. Paleo plays a role in about 5 of them. Its very important. But the other 15 count too. To discount them to me.....is a bad move. But remember for me the end game is healthy longevity and outliving my cohort. Medicine is both an art and science. What I advocate is meshing what we know is the best scientific evidence and what are the most likely new frontiers that research is moving too.....and then marrying them. That is my paleo

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 22, 2011
at 06:10 AM

Fixed. (sorry about that) please try me again.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 02:41 AM

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 02:51 AM

In a recent study from the American Journal of Clinical Nutrition , resveratrol was shown to: inhibit preadipocyte proliferation inhibits preadipocytes' maturation into mature adipocytes stimulates glucose uptake inhibits de novo lipogenesis cause a down regulation of the inflammatory cytokines IL-6, TNF-alpha, NF-kB, and IL-8 (IL-8 is proatherogenic- enhances CAD) Resveratrol increases production of rhBMP2 to increase bone mass.

93f44e8673d3ea2294cce085ebc96e13

(10502)

on March 22, 2011
at 06:24 AM

Also -- paleohackS.com (with s)

5f0158c23fcb5636e57b4ce097784da0

(1386)

on March 22, 2011
at 02:15 PM

@Dr.K 4g a day is rather impressive.. do you also notice an immediate effect (e.g. increased training tolerance), or do you purely take it for the long term benefits? what else do you take on a daily basis for optimizing health and performance if i may ask?

06d21b99c58283ce575e36c4ecd4a458

(9948)

on March 23, 2011
at 06:48 AM

Looking forward to your post on the 15 other factors for longevity on Paul Jaminet's blog http://perfecthealthdiet.com/

Af1d286f0fd5c3949f59b4edf4d892f5

(18452)

on March 22, 2011
at 04:09 PM

Resveratrol may indeed do all of these things you say here Doc. I wouldn't *necessarily* argue against it. However, I would question whether or not it's needed, based on the fact that you cannot eat enough to obtain the supplemental doses that you are advocating. What about just getting the polyphenols from foods and a bit of red wine here and there?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 22, 2011
at 01:00 PM

i did it with an S.....sticky keys! I sent another.

81a52efad6effda9eff3a3dcbc5f0ec6

(47)

on October 23, 2011
at 06:38 AM

Sinclair also kind of showed that the isolated resveratrol doesn't seem to quite work the way of those dry French red wines -- the reason being you need those other ingredients form the wine acting in cahoots with the reseveratrol to be effective. My impression is that taking reseveratrol is kind of like taking calcium: it doesn't quite work the way you intended, as it works in concert with ingredients that are mutually dependent on one another.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 22, 2011
at 09:03 PM

Resveratrol dosing for me during low light months goes even higher.

Medium avatar

(8239)

on October 22, 2011
at 10:33 PM

Jack, your overview of the data is terrific. I'm familiar with individuals with Parkinson's-like symptoms, who are doing mega doses of resveratrol. I'm assuming that what constitutes upper threshold dosage depends on factors like" whether the goal is reparative or preventive. With that in mind, what degree of supplementation do you consider appropriate for a healthy person (mid-50s) whose goal is (healthy longevity)? How did you hit upon your 4g daily dosage? What factors did/do you weigh?

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 23, 2011
at 02:43 PM

@Ipso This is a very fair critique. But if you read the totality of the data and research being done the good outweighs the bad in a biologic system. When you are a researcher you need to use that skeptic an eye.....when you are a doctor you must use that same eye and the other one needs to assess the clinical effect emperically. The third eye intuition dictates action and future questions to research. That is how I view it today. I am not dogmatic on resveratrol and have an open mind.......but right now use make more sense than not.

2b2c2e4aa87e9aa4c99cae48e980f70d

(1059)

on October 22, 2011
at 07:26 PM

Dr. K's Top Paleo Supplements: http://jackkruse.com/what-are-the-top-ten-paleo-supplements/

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on October 23, 2011
at 04:23 AM

David Sinclair's lab at Harvard show the upper limits for humans is over 250,000 mgs a day. The toxic dose is quite high apparently. For me I base the needs on my own lab testing. I have not talked here or on my blog about my circadian rhythmn theories and aging and metabolism but resveratrol dosing is tied to this. This is why when we go to low light situations I dial up the dose but in long light conditions I dial it down. It has to due with HS CRP and Vitamin D levels. PQQ also plays a role in FOXO activation and resveratrol may be antagonistic to this. So one has to pay attn to this

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!