Histamine Intolerance but needing high protein

Answered on September 06, 2018
Created October 18, 2014 at 5:25 AM

Hello, I have a leaky gut due to SIBO, where recently i was infected with a klebsiella bacteria, recently i have managed to clear this bacteria and use probiotics, vitamins etc for healing and building up healthy levels of bacteria. My recent report shows my good bacteria levels are good, and my igg food allergies have dropped, i used to have around 50 and now its around 10 or so foods.

The only problem now I have is, while being on a mostly meat, veg diet i seemed to have developed a quite strong histamine intolorence in the last few weeks. I am unable to tolerate meat, unless its very fresh otherwise i get heart palpitations or get headaches, im having to rely on nuts, seeds, and organice brown rice protein powder for protein at the moment.

Also in my recent report, it seems i have begun to loose muscle as ive stopped taking meat in, and previously i ate meat at every meal and felt it fueled my energy requirements. In my report it also showed I require 150 grams of protein per day for optimum muscle strength/building and im finding this bit difficult to achieve on the meatless diet, and have noticed my muscles and moving around is quite weaker compared to previously. It is interesting that I am not loosing weight or fat mass, but only muscle mass. 

I have begun to experiment on eating stir fry with lots of veg, coconut milk/w protein powder, and some flour based breads like buckwheat flour, chia, etc so i can get good protein still.. in some other way than meat.

How do I treat this condition and be able to eat meat again and keep up the protein requirements? Im almost looking to have to resort a DAO pill to have some protein. If the bacteria i had is gone, and alergies dropped, how come all of a sudden histamine is a big problem?

The diet restriction on the low histamine is doing my head in, as well as trying to find high protein foods to fuel my energy for the day... i am bit lost how to achieve this..

Anyone have any suggestions what i should be doing (either fixing the histamine, eating what exactly low histamine, high protein?) ?

Appreciate your help.. as im out of ideas really.. Thankyou


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6 Answers


on September 06, 2018
at 02:08 PM

Hi - I just found this thread. I was paleo for a long time, it suited me. I cannot cope with bread and milk so meat, fish, eggs and lots of vegetables seemed right. Then a period of semi vegan eating happened as was supporting partner with more than one cancer. I think my eyesight and oral health deteriorated and started back on my old regime after a couple of years and he is in remission. Great arthritis flare and histamine intolerance emerged almost immediately. I read and read every study I can. I have to listen to my body, it cannot cope with high fat, red meat etc. I have sort of got a way of eating now which is difficult to maintain and think gut bacteria must have changed.

Histamine intolerance is very difficult to cope with and be social, travel etc. Am now trying a probiotic with strains that are ok for people with histamine intolerance and swallowing K2 and cod liver oil pills for teeth/gums/eyes. Eggs are my salvation!  BTW L. reuteri is supposed to be bad for histamine intolerance.  Good luck to others with this problem.  i am glad there seems to be a commonality for a few of us, I thought it was just me!


on November 19, 2017
at 09:57 PM

If you are already histamine intolerant, bone broth is the worst thing you can add into your diet.  It's how many of us that began a Paleo lifestyle figured out the histmaine intolerance in the first place!  



on September 05, 2017
at 04:44 PM

Might not be relevant to anyones problems, but  those having intolerances to red meat might want to look into tick bites and subsequent intolerances to eating red meat.  Even if you were never bit by a tick or don't live in tick endemic areas, the immunilogical mechanism behind this sudden intolerance to red meat might shed some light on your own specific problems. It seems to all be immune related.



Also, anyone with a histamine intolerance should be aware that excessive protein can convert to histamine. Histadine is an amino acid found in protein, in high amounts it will convert to histamine and raise your histamine levels.

Certain bacteria found in the digestive tract can also take the histidine in any food and convert it into histamine. In other words, if a person does not have a fully healthy digestive tract, there is a chance that his or her body will end up with too much food histamine, not because that histamine is found preformed in food, but because the histidine amino acids in food are being converted into histamine inside of the digestive tract. In this case, avoiding high-histamine foods won't help a person nearly as much as restoring digestive vitality and digestive tract function."



on November 13, 2014
at 08:48 AM

I am like you. I used to be able to eat meat without any problem, however, last year I had a weird infection in my mouth and throat then a week later, I became so intolerant to meat, and it gave me all the same symptoms as my amine intolerance (I react to other amines besides histamine, such as tyramine). The only difference was that it was a delayed response. I felt great when I did not eat meat, as I was trying to avoid grains and sugars etc, I felt like there was NOTHING I could.

I did a GAPS introduction diet for 4 months and just felt worse and worse. I coudln't walk up the stairs without such fatigue in my musles and my heart pounding, my postural hypotension went crazy and I could feel the ache building in my knees each time I bent down, that always told me I would be dizzy standing up. I had been on GAPS before and I had a rough start, but not like this. I actually developed greater tolerance of Amines on my first stint on the GAPS diet. However, I think that the people who advocate it put all symptoms to microbial die off. I think that feeding a high protein diet is likely to select for bacteria that like to munch on protein. A number of species produce histamine from the digestion of histidine in protein. Which is why I can't tolerate yoghurt.

There are also bacteria that degrade histamine or ones that are at least neutral in this regard and I have been experimenting with them. I have tolerated them well so far - in particular - L. rhamnosus, L plantarum, B infantis and B longum. I have also been taking Bacillus subtilis - a soil bacteria, and Saccharomyces boulardii. I have also been taking the brank NOW Thyroid energy, as I noticed that lots of the vitamin/mins in it are also the precursors required for DAO production. I have felt much less tired since I started taking it and has made me more regular too. 

I think that gut dysbiosis can not only be about species that are carbohydrate eaters, but also protein eaters. The balance is important and also making sure we get the right species to support the right pH for the gut that makes it inhospitable to the pathogenic species. 

I have been taking histame whenever I eat too much meat and I have yet to reduce my tolerance and find a solution, however, I have only recently started the probiotics. There is so much info out there - it is hard to know what to do. Some say avoid starches, some say eat resistance starch, both trying to get the same result. 

If anyone else has more info to add to the puzzle, I also would like to hear from them.





on October 26, 2014
at 01:07 AM

probiotics may help with the histamine intolerance. L. reuteri for example. The Animal Pharm blog will have some suggestions for you.   Also, I think eating foods high in quercetin has helped my spouse.  For example, "pesto" made with thyme and lots of onions.   This blog has been helpful   http://alisonvickery.com.au/

Chris Kresser's blog also


If you still have issues after a month or so, be sure to check into the MTHFR possibilities. 



on October 22, 2014
at 01:24 AM

Are you already including bone broth in your eating plan?

Also, gelatin is easy to add to meals, or to drink in liquids. It will not only help you to increase your protein intake, it is very good to help heal a leaky gut.

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