Bulletproof Diet - Does protein inhibit autophagy?

Answered on August 19, 2014
Created November 27, 2012 at 1:02 AM

Hey there Hackers!

I wanted to enquire about the process of autophagy, more specifically how protein inhibits it. I've been using intermittent fasting for about 4 months now and I enjoy it, both from a training perspective, as well as eating. I would say that I'm healthier because of it. I wouldn't say I've lost much weight, but that could be from a broken metabolism, or me disobeying the common law of thermodynamics. I'm babbling, I'll get to the point.

I've been interested in the whole "Bulletproof" concept for a while now, and going for a more organic way of living (even though I can't afford it... it's more the ideas behind it and the benefits that can be had). One concept that interests me is the Bulletproof Coffee.

Now, varying sources say that ingesting ANY type of food will inhibit autophagy and negate the benefit of fasting. Dave, on the other hand, states that it is the consumption of protein/carbs that does the damage and that consumption of fats can perhaps even PROMOTE autophagy within the body.

I'm probably going about it the wrong way, I've been using MCT Oil and Westgold Butter (I'm an Aussie) in what I feel to be substandard coffee, and yet feel pretty good on it. But for all of you scientific hackers out there... are there any studies that can further show that the ingestion of fat won't inhibit autophagy and that it is protein/carbs that do?

If you've made it through all this... thanks.

~ Cricket

p.s. If Dave Asprey himself could chime in on this, it would be greatly appreciated :)



on February 14, 2013
at 08:56 AM

Dave has mentioned the process of autophagy before, as have a few hackers. It's more the science that interests me. I've diagnosed the weight stall and am back onto it. And yes, I know he doesn't mention it there, but if you go further into the site, you'll find that he does mention it.. but doesn't give much reference to it.



on February 12, 2013
at 09:59 PM

Not a direct answer to your question, but I have to ask. If you've been fasting for 4 months with weight loss as a goal and have not lost weight, then I think your #1 question should address diagnosing that problem. This specific question about autophagy seems irrelevant. As you can see on the linked page from the bulletproof site, he doesn't even mention autophagy.

  • 125dfe387c83d848c2fe92de6d8bfdf0

    asked by

  • Views
  • Last Activity
    1826D AGO
Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

3 Answers


on February 26, 2013
at 08:35 PM

Good luck ya'll. There's hardly ANY research studies on autophagy. anyone claiming to have any solid knowledge about when autophagy actually starts it's just blowin' smoke



on January 29, 2013
at 06:40 PM

Hey Cricket!

I have been doing the bulletproof diet with IF for a month now, and I really enjoy it too. I too am curious about the fat thing in the morning. I drink bulletproof coffee in the morning and only eat from 2-8 pm. In my curiosity, I tried doing it without the BP coffee and it was pretty horrible (I was hungry, irritable, and unfocused). Whether it's technically breaking your fast or not, the fats from the BP coffee seem to give me the brain boost that Dave talks about. I have looked for other sources on the matter, but all I get are body building forums with little or no scientific data. Maybe it's just too new of a concept for there to be data on the matter yet. I am tracking my own progress and blogging about it at: http://bulletproofcoffee.wordpress.com/

I have thought about doing an extended period of IF without the BP Coffee but every time I seriously consider it I talk myself out of it haha. If you find any more info or figure anything out yourself, please let me know and I will do the same! Do you have a blog or anything?




on December 01, 2012
at 02:04 AM

Asprey covers this extensively on his web site. You can scroll through the endless comments here: http://bit.ly/RjdOyG

Answer Question

Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!