6

votes

can you use a probiotic capsule as a rectal suppository?

Asked on February 06, 2018
Created September 23, 2012 at 5:24 AM

I am not sure if I believe that probiotic supplements ever make it past the stomach, much less into the colon. since starting Paleo low-carb and stopping caffeine, I am constipated, and fermented foods and drinks and probiotic supplements have done nothing. I eat veggies and they also don't help. I think the bacteria in my colon is underpopulated, and so I was wondering if I could use my probiotic supplements as a suppository or enema. This seems like it could work great, or perhaps it could go disasterously wrong.

what does thee think?

70dcf5556257f08746aea3a21773c021

on December 04, 2014
at 06:58 PM

Thank you so much for your input. I really do believe that IBS/IBD is mainly caused by poor population of good gut flora as well as underlying emotional issues/stress. I have Crohns disease which really never gave me too much of a problem back in the day. However, after a round of Flagyl, I had developed C-diff. Ever since that time I have never been the same. Can never seem to be out of a flare for more than 5 months. I would love to know more about the FMT and the trial that is going on. I would love to be a part of a trial that could help me.

Thank you again for your time,

Patricia

F0a0388780f840769af6aaba400a9d7a

(10)

on May 23, 2014
at 06:45 PM

72cf727474b8bf815fdc505e58cadfea

on July 11, 2013
at 02:28 PM

This might be a terrible idea, but it is an intelligent response to the concern that putting probiotics in your rectum won't let the get far enough up.

1deaea445ff3b1cb5d1354a043dc8fb7

(275)

on May 10, 2013
at 10:36 PM

this sounds possibly dangerous, i would only try it if there is some sound science behind this

6120c989fd5b69f42a0834b69b87955b

(24553)

on May 10, 2013
at 08:48 PM

Egads! Do not put Gogurt up your rear. Those have almost no probiotics, and a shitload of sugar and weird binders.

Ba20b502cf02b5513ea8c4bb2740d8cb

(1669)

on September 24, 2012
at 02:31 AM

LOL! Thanks for that question, even though I'm sure it wasn't facetious or anything but it made me laugh. I would eat sauerkraut instead...

D5dff6376e17373751ccf4a10aaa0b34

(274)

on September 23, 2012
at 10:17 PM

Because there are many hundreds of strains in the intestine which go there through means that science doesn't understand well. The mechanisms for oral use of probiotics could have nothing to do with direct colonization. Whatever the mechanism the evidence for benefit is low. The likelyhood of influencing the gut biome through a few strains is low. Fecal transplants are the only proven method. I'm not against relatively harmless things that are regulated by normal digestion, because the risk and cost is low, and it might have some benefit, even if unproven. But directly is too invasive.

0a9ad4e577fe24a6b8aafa1dd7a50c79

(5150)

on September 23, 2012
at 04:15 PM

Supposedly bifidus is bad to take orally if you have SIBO, so if there ever was a good time to use a probiotic as a suppository, it would be if you have SIBO. I wouldn't waste your money on single bacterial strain probiotics though.

76211ec5301087de2588cfe3d6bccba9

(1178)

on September 23, 2012
at 04:09 PM

would it be a good idea to start with a single strain bifido supplement for instance?

1d0497f8781845ab371b479455bfee8e

(11157)

on September 23, 2012
at 04:03 PM

Or poke a hole into the capsule so it can leak out gradually.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on September 23, 2012
at 03:27 PM

Yeah I disagree with the lack of benefit too. It makes more sense than oral, as in the colon is where bacteria belong, and stomach acid kills bacteria. But I think that it is an unexplored area, so youd want to stick to trialled and tested strains, in lower doses to be sure its safe...

0a9ad4e577fe24a6b8aafa1dd7a50c79

(5150)

on September 23, 2012
at 02:07 PM

Why do you say its unlikely to provide benefit? The whole reason why probiotic pills generally sucks is because they have to pass through the stomach and entirety of GI tract to colonize the gut. Probiotic enema = DIRECT adhesion to the intestinal tract without killing any bacteria en route via digestion.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on September 23, 2012
at 07:17 AM

Theres some japanese dude I read about who had great success doing this, after oral failed him. He recommened using milder probiotics (low amounts of live bacteria), and only certain strains.

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19 Answers

5
1ef2c3bfd6bb37877b02fddc819bebac

on September 23, 2012
at 06:33 AM

I've worked with suppositories before (med tech) and I can tell you that they will start melting right away when being handled. That leads me to think the gel caps with oral meds won't break down the way a suppository will.

Have you tried cultured coconut milk or sunsweet prunes? Prunes have become an every other day thing for me. Just some suggestions if you haven't tried them yet.

I am not exactly sure if it is what you had in mind but I wouldn't put something in your rectum that isn't designed to be there. You could injure your body or have (over)absorption problems. Also keep in mind, suppositories go in your rectum, which comes after your colon, which might cause logistics problems if you're trying to get it all the way to your colon like you indicated.

4
0a9ad4e577fe24a6b8aafa1dd7a50c79

on September 23, 2012
at 06:40 AM

Yes, you can.

I've done it. But you're better off opening the capsule, pouring the bacteria into an enema bottle and giving yourself a probiotic enema.

1d0497f8781845ab371b479455bfee8e

(11157)

on September 23, 2012
at 04:03 PM

Or poke a hole into the capsule so it can leak out gradually.

72cf727474b8bf815fdc505e58cadfea

on July 11, 2013
at 02:28 PM

This might be a terrible idea, but it is an intelligent response to the concern that putting probiotics in your rectum won't let the get far enough up.

3
80f1d03212da7a3447946f93561c372b

on February 17, 2013
at 04:44 PM

..get educated on microbiom. mayo clinic has been doing poop transplants for years to treat those with c difficule infections ( successfully ), it was first done at denver medical center in 1987, now they are doing this to treat crohns, a clinical trial is going on in MA for IBS , and another trial for leaky gut treatment.

IMO harmless to do probiotic suppository .. .if I was going to do a suppository or enema with probiotics i would make sure of what else was included in that.. probiotics are harmless.

the only way single strain is effective is if you do a test to see what bad bacteria are in the gut ( Genova etc ) and then specifically target it with the right good probiotic proven to dominate that specific bad bacteria. People are doing it.. Tests cost money.

'' future may lie in concocting specific probiotics for people based upon their individual needs and microbiomes. ' Dr. Mullin Johns Hopkins

2
00038a873c5ccf6410d8432e58e27426

on July 29, 2013
at 12:46 AM

Multistrains are best, for sure, but yes you can use the capsules as suppositories.

This is best immediately after you have voided or have performed an enema, and right before a long sleep is best. There are no ill-effects. I have done this many, many times, and the only notable effect was some modicum of gas, nothing more. No pain --I see a lot of needless panic, up there.

Think it over --if you had probiotics without enteric coating, how many might survive 30 minutes in any environment with a pH of about 1.2...? That's a strong acid. Do you think a human could swim around in that? How about something lacking any kind of skin..? I believe it's unlikely that even as much as 1% of the viable content of standard probiotic capsules reach the intestines --the only place they would actually do the patient any lasting good.

As a much more advanced experiment you could do a probiotic culture in a suspension of chicory root and artichoke for 8 or so hours, and then do a retention enema of the resulting suspension. Google those two prebiotic inputs if you wonder why.

I'm doing that later on, and I might come back here and describe the results. The only question in my mind is if they get high enough in the gut to do lots of lasting good. I believe lots of manipulation would be required for positive results.

I can't believe how much alarmism I'm seeing up there.

1
F0a0388780f840769af6aaba400a9d7a

on May 23, 2014
at 07:31 AM

P.S. Dr. Ohhira's probiotics and the pearls are designed not to dissolve until they are in the colon.

F0a0388780f840769af6aaba400a9d7a

(10)

on May 23, 2014
at 06:45 PM

1
A063a9482337adabf97a7d29b2b5721c

on July 11, 2013
at 10:12 AM

I don't think you can "repopulate" your colon with the new probiotics. They are designed to not have spores. They don't "plant" a culture. (They want us to keep buying them.) Also, Time-release probiotics would be best. Also, lately I theorized it's best to eat very very light for a few says so the intestines are emptier, to allow deeper passage of the probiotics into the colon. The empty highway is easier to travel. P.S. For constipated, I use Milk of Magnesia.

1
47cfe5a1cc8fcd896dcb905e5d751e23

on April 04, 2013
at 12:35 PM

Try: Probiotic Pearls Rectal Suppository

1
D5dff6376e17373751ccf4a10aaa0b34

(274)

on September 23, 2012
at 07:31 AM

I would avoid, as it unlikely to provide benefit and you could end up with an infection or injury. The mechanism for oral probiotics is not well understood and based in the incredible complexity and number of organisms in your gut, adding a few random varieties in random quantities isn't going to do much. If you are constipated try magnesium or something from the pharmacy...don't suffer. I accidentally took in too much olive oil the other day...that seemed to work..ymmv.

76211ec5301087de2588cfe3d6bccba9

(1178)

on September 23, 2012
at 04:09 PM

would it be a good idea to start with a single strain bifido supplement for instance?

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on September 23, 2012
at 03:27 PM

Yeah I disagree with the lack of benefit too. It makes more sense than oral, as in the colon is where bacteria belong, and stomach acid kills bacteria. But I think that it is an unexplored area, so youd want to stick to trialled and tested strains, in lower doses to be sure its safe...

0a9ad4e577fe24a6b8aafa1dd7a50c79

(5150)

on September 23, 2012
at 02:07 PM

Why do you say its unlikely to provide benefit? The whole reason why probiotic pills generally sucks is because they have to pass through the stomach and entirety of GI tract to colonize the gut. Probiotic enema = DIRECT adhesion to the intestinal tract without killing any bacteria en route via digestion.

D5dff6376e17373751ccf4a10aaa0b34

(274)

on September 23, 2012
at 10:17 PM

Because there are many hundreds of strains in the intestine which go there through means that science doesn't understand well. The mechanisms for oral use of probiotics could have nothing to do with direct colonization. Whatever the mechanism the evidence for benefit is low. The likelyhood of influencing the gut biome through a few strains is low. Fecal transplants are the only proven method. I'm not against relatively harmless things that are regulated by normal digestion, because the risk and cost is low, and it might have some benefit, even if unproven. But directly is too invasive.

0a9ad4e577fe24a6b8aafa1dd7a50c79

(5150)

on September 23, 2012
at 04:15 PM

Supposedly bifidus is bad to take orally if you have SIBO, so if there ever was a good time to use a probiotic as a suppository, it would be if you have SIBO. I wouldn't waste your money on single bacterial strain probiotics though.

0
2fd143eb9a6537a38f599801bee15a7a

on February 06, 2018
at 03:35 PM

in many research studies, they use rectally administered enemas. Just head to google scholar and search for "probiotic enema" and look into the many studies listed (sorry that I do not link it but this stupid forum software prevents me from posting links...). And head to the "methods" section for what exactly they use for the enema. Also, each study has a side effects section.

Your question is not about enemas but about popping a pill into the anus... I am not aware of any study doing that. But the idea may be not completely awkard because caps typically do dissolve without stomach acid. Just try this: throw capsule into a glass of water and see what happens. I tried it and after minutes, the capsule content started diffusing through the capsule shell. Was interesting to see. :) However, I have a simple logic why I dont put capsules into my ass: this is uncharted territory for me, and while am a researcher, I am not a proctocolist or such ... so I will simply do it as others did it: rectal enema.

I am preparing to do a rectal enema using the probiotic, BC-30. This strain helps another gut bug, the Faecalibacterium Prausnitzii to proliferate. I tested low on the latter. Check out the Brigg's protocol for the significance of all this. It is the best treatment plan for inflammatory gut conditions I came across. I do not have Crohn's but some somewhat similar mysterious undiagnosable inflammatory gut condition... let's see if it helps... :)

I am new to this forum, this is my first post... I hope I won't forget to report experiences.

0
F0a0388780f840769af6aaba400a9d7a

on May 23, 2014
at 07:28 AM

When you eat cleaner you naturally detoxify. You awaken toxins as your body cleanses itself. Your body's main way to eliminate toxins are via the bowel. Sometimes when you eat cleaner you awaken more toxins than your bowel can handle, which results in constipation. To really enjoy the benefits of a clean diet, get a gravity method colonic to remove the excess toxins and help tone the bowel. Read 'The Raw Food Detox Diet' by Natalia Rose or 'The Body Ecology Diet' by Donna Gates for more information. Peace out @nursling

0
F0a0388780f840769af6aaba400a9d7a

on May 23, 2014
at 07:27 AM

A

0
Medium avatar

on April 28, 2014
at 06:19 PM

I highly recommend you purchase probiotic suppositories instead of using an oral capsule. Most digestion/absorbtion occurs where contents leave the stomach and enter the small intestine. Very little absorbtion occurs in the rectum/large intestine, which is why suppositories are specifically designed for absorbtion in the rectum.

0
3491e51730101b18724dc57c86601173

(8395)

on April 28, 2014
at 03:14 PM

There is a lot of stuff on the net right now about the fact that taking probiotics (orally) with resistant starch helps to get the probiotics through the upper GI tract and into the large colon. The RS essentially protects the probiotics to help them get to the right place.

0
4e184df9c1ed38f61febc5d6cf031921

(5005)

on April 27, 2014
at 05:02 PM

@nursling I'm pretty sure that quite a lot of bacteria DO make it intact through the stomach acids and survive to do their work. This is how e coli, orally ingested, gets into the intestines and causes such trouble - as well as lots of other bacteria which cause stomach upsets. You only have to travel in some places - Turkey is one I suffered in - and see how quickly the little bugs you've inadvertently eaten cause havoc.

And I simply can't believe that the good bacteria are less well adapted to survive the same route. Which is why I eat sauerkraut, kefir, kvass etc and why they seem to have done such fantastic work for me.

0
546fe357ec669219ea641c44af81ada6

on April 27, 2014
at 03:06 PM

What I have been doing for a really bad case of candida infection is using 50 Billion 10 type probiotic gell caps, I empty one into a glass of cold water stir and stir, it tastes a bit funky but washing the last gulp around your mouth and gargling is going to mean direct contact with affected areas, Thank fully, I'm not getting candida build up under my foreskin, that is not to say its not there though i just wash well and probably hide it. BioLive yougrt can be used for that.

After the glass i melt another one into a small dish with just enough milk to dissolve it, use about 0.25-0.50ml, do not apply any heat this must all be cold, i spend about a few mins mixing it into a solution and suck up into a 1.5 ml syringe, using the very tip i gently push against the anus and squirt it in slowly.

After the really bad infection (still present only 1 week in) which causes major bloating, rectum bleeding and awful flatulence (no laughing matter when you are in a board meeting) in one week in and i have lost 1.5 inches of my waist, i can eat white bread without looking like a balloon and having less problems with blood spotting on paper after passing stools.So far I think this is working and the going in from both ends seems to be really helping. See what works best for you, a inserted solution will be better than suppository.

Last thing is how much your diet needs to change to stop over growth of nasties in the digestive tract. hope this post could be of some help to someone. A 3 year old thread but still, it popped up close to the top with a google search of "Probiotic Suppository"

0
C81aba65e00a35edea25d8449aaaa5d8

on May 10, 2013
at 07:24 PM

Jamie, What was the name of the Japanese guy you mentioned?

0
B199489ae8b78b49cb2a635e3675df23

on March 08, 2013
at 05:13 PM

I just started doing colonics. i highly recommend. if you can't afford/not close by try home enema. very important because you are eating the right foods. but if they are blocked by old waste, they will bloat. that is known. i was afraid to try colonic, but I LOVED IT IMMEDIATELY!! especially knowing all that old waste was leaving...

0
68655ec9711d207d69a63ebf96b37573

on February 17, 2013
at 08:08 PM

I'd do it, but first, see if you can get one of those enteric-coated probiotics that are resistant to stomach acid.

I do vaginal suppositories when I have a yeast infection and it works quite well.

Or you could try beetroot, roast at home in a lot of coconut oil, works well for me

-1
Dea5e00f75508803ddab2da06dc97508

on May 01, 2013
at 06:24 PM

You might consider one of those fandangled lil yogurt squirts.... Go-Gurt i believe is the name. Many flavor options for the event of "backdrafting"if such a thing could ever occur....

6120c989fd5b69f42a0834b69b87955b

(24553)

on May 10, 2013
at 08:48 PM

Egads! Do not put Gogurt up your rear. Those have almost no probiotics, and a shitload of sugar and weird binders.

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