5

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paleo brain without carbo intake

Commented on September 02, 2016
Created January 29, 2012 at 7:48 AM

Brain on paleo diet is without sufficient glucose for functioning.
Usual myth is brain works on glucose. Then how brain on paleo diet works without any problem?

I guess ketone bodies are utilized in Na K pump in neurons. Key question is: is there enough efficiency in kinematics for ketone bodies in Na K pump compared to glucose. What are differences of ketone bodies and glucose in functions in different parts of brain such as prefrontal cortex, anterior cingulate cortex, insula and hippocampus relevant to my brain activities.

Personally I do want my brain work in optimum level. Although n=1 experiment on myself, I have clear mind and not fatigued in my mental activity upon rigorous discipline of paleo lifestyle.

I try to locate resources for bio/electro chemical mechanisms for brain functioning(especially in synapses and in propagation of signals in axons) in paleo context and very hard to find literature accessible to me.

Ed6f4e5e3580fa31881bd88d3d14c1b7

on September 02, 2016
at 03:19 AM

Is been 3 months I quit sugar, coffe, all types of pasta rice and meet, work out 6 times a week and work in a standing and walking job in retail.

I defenitly feel something is not right, since I am not able to get my braing fog feeling away.

I try eating brown rice but I felt I had an alergic reaccion. Recently had a conversation with a friend.

Without knowing it, I went no carbs at all for a 2 months and excersising 6 times a week, 3 days swimming 45 m and 3 days working out 1 and 30m.

I had to lose waight to recover my foot from 6 fracutures. I lost since april 30, 34 pounds.

Got use to not having coffe or sugar after going through some crazy withadrawls, I feel great.

The only problem is that sometimes I feel a brain fog in my brain. I tought maby was when I consume gluten and have a gluten intolerance since I took gluten of my diet for 3 months.

I start to realize I might have Ketosis and a big B12 deficency. I started taking vitamins and b complex with magnesium, omega 3 and potasium; I know I lost mussle tissue at this point.

Againg I only ate salads, fish, avocado, potatos, bananas, strawberries, bluberries and maby 1 or 2 packs of pistachos and nuts in 3 months over and over..

What should I do how do I recover from this, since trying to eat carbs now like brown rice and bread give me brain fog as well?

Ccacf7567273244733bc991af4ac42ed

(5198)

on January 31, 2012
at 02:51 PM

It looks like some brain cells are too small to contain mitochondria. My guess would be for microglia being the ones that require glucose. It's possible the rest of the body ends up requiring more glucose though.

2bc6d4294c42a78bf9e7c754f87ef427

(172)

on January 31, 2012
at 02:09 PM

PrimalDanny, which parts of brain require glucose? Are there neurons without mitochondria? Ketone bodies release acetyl_CoA which enters into tricarboxylic acid cycle. If all neurons contain mitochondria, why does some brain require glucose?

9dd4d453f7ebd7fd2a82814d08fc8f17

(581)

on January 29, 2012
at 05:29 PM

i completely agree the body can make all the glucose the brain needs. i can testify to that since i've been eating zc (only meat and lard) for over 3 months. and my brain works just as sharp (as long as i eat enough fat).

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7 Answers

best answer

1
D31a2a2d43191b15ca4a1c7ec7d03038

on January 29, 2012
at 02:19 PM

If I remember correctly, Dr. Emily Deans' blog, Evolutionary Psychiatry, has a couple of statements about which parts of the brain need glucose and which run on ketones. I don't have time to do a search for those, but here is the main link to her blog:

http://evolutionarypsychiatry.blogspot.com/

I don't know if Lucas Tafur posted something at his blog, Ketotic

The folks at Dirty Carnivores might know.

Sorry I can't give specifics. It would be nice to know.

best answer

1
6714718e2245e5190017d643a7614157

on January 29, 2012
at 03:05 PM

2
4b8ce2e8143119b39e00d5705b76cfa6

on February 02, 2012
at 11:05 AM

There is a video on YouTube called "Sugar: the Bitter Truth" which contains quite a bit of biochemistry information, including how your liver can turn fat into glucose. You don't need very much, in 6 litres of blood there is only about a teaspoons worth of glucose in normal (read "Paleo") people.

2
Ccacf7567273244733bc991af4ac42ed

on January 29, 2012
at 12:25 PM

If you can't find the detail you need in the literature then I don't know that I can suggest anything that will help, so I'll just add the basic conclusions as I understand them. Any studies will have complicating factors that don't necessarily relate to a strict paleo lifestyle.

Glucose is required by some parts of the brain, and the body is capable of creating enough by gluconeogenesis to satisfy this requirement. The rest of the brain can function on ketones, and it is disputed whether the brain is more efficient or not. Obviously optimal brain function is hard to define, although it may be clearer in strict physical terms.

9dd4d453f7ebd7fd2a82814d08fc8f17

(581)

on January 29, 2012
at 05:29 PM

i completely agree the body can make all the glucose the brain needs. i can testify to that since i've been eating zc (only meat and lard) for over 3 months. and my brain works just as sharp (as long as i eat enough fat).

2bc6d4294c42a78bf9e7c754f87ef427

(172)

on January 31, 2012
at 02:09 PM

PrimalDanny, which parts of brain require glucose? Are there neurons without mitochondria? Ketone bodies release acetyl_CoA which enters into tricarboxylic acid cycle. If all neurons contain mitochondria, why does some brain require glucose?

1
246ebf68e35743f62e5e187891b9cba0

(21430)

on January 29, 2012
at 04:29 PM

Empirically, my brain functions much better with a cup of strong coffee and a tablespoon of coconut oil, than it ever did on my usual oatmeal and coffee pre-Paleo. And this is after cutting my daily sleep schedule considerably (going from 10 hours/night to 6-7 and waking without an alarm clock).

0
2bc6d4294c42a78bf9e7c754f87ef427

on January 31, 2012
at 02:26 PM

Thanks for references, RichfrmTx and PaleoGran. From studying these valuable sources. I gain new insights.

Does brain require glucose really? Since active Na-K pump in axons and active Ca pump near synapses consume ATP which mitchondria provide through acetyl Co-A from ketone bodies. If all of soma and axon contain mitochondra (which I have not yet confirmed in literature), then perhaps brain can perfectly function without glucose (even though available through gluconeogenesis as pointed out by PrimalDanny)

Ccacf7567273244733bc991af4ac42ed

(5198)

on January 31, 2012
at 02:51 PM

It looks like some brain cells are too small to contain mitochondria. My guess would be for microglia being the ones that require glucose. It's possible the rest of the body ends up requiring more glucose though.

0
Cf4576cbcc44fc7f2294135609bce9e5

on January 29, 2012
at 03:32 PM

paleo man ate paleo food for 3 million years. our brains have experience dealing with paleo food just fine. this is no issue here. kind of dissapointing really.

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