6

votes

Aubrey de Grey claims that ketosis can accelerate aging and increase mortality

Answered on August 19, 2014
Created February 19, 2013 at 9:16 PM

In his book, aubrey de grey claims that being in ketosis induces production of an oxoaldehyde called methylglyoxal, which is a major precursor to AGE which build up in tissues causing loss of function and aging.

I've never heard this before, but if a guy like de grey is saying it, I'm taking it seriously.

What do you think?

61844af1187e745e09bb394cbd28cf23

(11058)

on February 20, 2013
at 04:31 AM

WTF?????????/??

B4e1fa6a8cf43d2b69d97a99dfca262c

(10255)

on February 20, 2013
at 04:22 AM

i eat VLC about 90% of the time and have for over 2 years. i don't wear sunscreen or use "product" except for the occasional coconut oil treatment on my feet and i don't look like a 51 year old. maybe i'm an exception to the rule, but most people believe i am in my early 40's. as i like to point out; you may not be like me.

Bfd70bb38267fcc2d762063d691fa226

(723)

on February 20, 2013
at 12:54 AM

I agree with thegiantess. Ketosis is great for losing fat and may be a good diet for those who for are not very active. When doing intense training like Crossfit, your performance will likely start to suffer if your carb intake is too low. that being said, nobody said to eat a crazy amount of carbs either. there is a difference between a low carb diet according to SAD standards and a diet based on ketosis

3846a3b61bc9051e4baebdef62e58c52

(18635)

on February 20, 2013
at 12:53 AM

http://paleohacks.com/questions/74462/wheres-the-proof-that-glucose-metabolism-generates-more-ros-than-that-of-lipids#axzz2I5TpM4qX

F2cd77a6d2133ca3ae5b4353c4047577

on February 19, 2013
at 11:11 PM

Why are you looking at ketosis as a binary state of the body? I'm not saying it's linear, necessarily, but varying degrees of ketone concentrations likely have different consequences to one's health.

9f54852ea376e8e416356f547611e052

(2957)

on February 19, 2013
at 11:09 PM

The keto crowd has not been nearly as militant lately as they used to be.

77877f762c40637911396daa19b53094

(78467)

on February 19, 2013
at 09:42 PM

It's called "ending aging", I've just read it to. A quick google search confirms that ketosis does indeed induce the production of oxoaldehyde.

61844af1187e745e09bb394cbd28cf23

(11058)

on February 19, 2013
at 09:39 PM

What book? Do you have a link?

A83848dfff3363c53f93831f2e03710c

(50)

on February 19, 2013
at 09:29 PM

his beard accelerate's aging and mortality for me every time i see it.

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7 Answers

6
06bf7b92d77f1ac1d8e3dc9d539d8254

on February 19, 2013
at 10:45 PM

Personally, I think ketosis is a tool to be used for those who are in some way damaged. For example there is evidence that ketosis is beneficial for those with brain related disorders such as epilepsy. Additionally, someone extremely overweight or metabolically damaged might use ketosis as a tool to recover and then slowly add back carbs as they heal. I don't think ketosis is a sustainable way of living/eating for the long term and because of that it makes logical sense that ketosis might accelerate aging in the long run.

From a purely logical perspective your body has to work a whole lot harder to thrive while in a ketotic state. That is just my opinion. I am sure I will catch hell from the fat devotees.

9f54852ea376e8e416356f547611e052

(2957)

on February 19, 2013
at 11:09 PM

The keto crowd has not been nearly as militant lately as they used to be.

Bfd70bb38267fcc2d762063d691fa226

(723)

on February 20, 2013
at 12:54 AM

I agree with thegiantess. Ketosis is great for losing fat and may be a good diet for those who for are not very active. When doing intense training like Crossfit, your performance will likely start to suffer if your carb intake is too low. that being said, nobody said to eat a crazy amount of carbs either. there is a difference between a low carb diet according to SAD standards and a diet based on ketosis

B4e1fa6a8cf43d2b69d97a99dfca262c

(10255)

on February 20, 2013
at 04:22 AM

i eat VLC about 90% of the time and have for over 2 years. i don't wear sunscreen or use "product" except for the occasional coconut oil treatment on my feet and i don't look like a 51 year old. maybe i'm an exception to the rule, but most people believe i am in my early 40's. as i like to point out; you may not be like me.

F2cd77a6d2133ca3ae5b4353c4047577

on February 19, 2013
at 11:11 PM

Why are you looking at ketosis as a binary state of the body? I'm not saying it's linear, necessarily, but varying degrees of ketone concentrations likely have different consequences to one's health.

4
F2cd77a6d2133ca3ae5b4353c4047577

on February 19, 2013
at 11:12 PM

Before people start to press the panic button, please take the time to read:

http://healthcorrelator.blogspot.com/2010/03/ketosis-methylglyoxal-and-accelerated_14.html

1
E253f8ac1d139bf4d0bfb44debd1db21

on February 20, 2013
at 02:11 AM

Distinguish between ketosis and ketoacidosis.

Also De Grey thinks you can cure aging without having any idea on why aging occurs - his so called 'engineering approach'.

However an interesting point has been raised and its worthwhile looking into the long term consequences of any dietary regime that constrains the metabolism.

1
7f8bc7ce5c34aae50408d31812c839b0

(2698)

on February 19, 2013
at 11:16 PM

First I would question which part of "being in ketosis" was the damaging part. Is it the generation of ketones by carbohydrate reduction that produces the methylglyoxal or is it the metabolism of the ketones as a fuel that generates the methylglyoxal?

I try to eat just enough carb to be mostly NOT in ketosis due to carb restriction, but I consume a lot of MCT oil so that both glucose and ketones are available for my brain to use.

0
Cfec3fb17e6d06f984ffedc2aae54920

(150)

on February 20, 2013
at 12:47 AM

I agree that ketosis should only be for short-term such as weight loss. I find that I can't sleep on very low-carb - I have to eat something before going to bed (tsp of PB) or I'll eat dinner 2 hrs b/f bed.

0
5616e8de3e99ae199d9fd896098a331a

on February 19, 2013
at 10:58 PM

No need to worry, he will make us immortal anyway.

0
77877f762c40637911396daa19b53094

(78467)

on February 19, 2013
at 10:44 PM

I'm surprised nobody has answered this- maybe we're all off on google Ann's aren't so 100 sure anymore?

61844af1187e745e09bb394cbd28cf23

(11058)

on February 20, 2013
at 04:31 AM

WTF?????????/??

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