4

votes

Are we missing anti-cancer nutrients from grains and legumes? IP-6 & inositol?

Answered on August 19, 2014
Created October 02, 2012 at 2:22 AM

I get sick once a year when the season changes. A few years back (before I was paleo) I found a blend by Enzymatic Therapy called Cell Forte Max 3. I have used it a few years in a row when I start get a cold and it knocks it out immediately. I stumbled across it when looking for Maitake Gold because I had a sample of that once and it did the same thing. So I thought it was the Maitake that made this stuff so potent but I tried a blend of Maitake with some other adaptogenic mushrooms and that never seemed to do anything to help me feel better. (Max3 contains IP-6, inositol, Maitake and Cat's Claw).

So it's that time a year again and when I was thinking I should go buy some I decided to research it online first. It turns out that the IP-6 is from rice bran. When I went to Vitamin Shoppe to get something to help me out I found a powdered blend of strait IP-6 & inositol marked 50% off making it $35 instead of $70. The girl working there said that it's a powerful immunity booster and is used by cancer patients.

I know how well it works from experience but I decided to do more research and just bought some herbs and such. So in doing this research I found a study that has me concerned that we may be missing this vital nutrient by not eating grains and legumes.

The study that has me thinking that is called "Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic."

From the paper:

"How can exogenously administered IP6 affect tumor growth? Pioneering experiments showing this novel anticancer feature of IP6 were performed by Shamsuddin et al. (18???20), who were intrigued by the epidemiologic data indicating that only diets containing a high IP6 content (cereals and legumes) showed a negative correlation with colon cancer"

http://jn.nutrition.org/content/133/11/3778S.full

I just started researching this stuff yesterday so I need more info. I'm torn between thinking the supplement is not safe because of it's origin and thinking that perhaps it's a very important nutrient that we're missing out on.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 02:53 AM

Oh, coenzyme q10 was the one I was thinking of. I think liver also increases glutathione as well somehow.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:14 AM

Still polyphenols may either increase uric acid (indirect function), or operate via hormesis, so theres still likely benefit to eating them in normal foods, in moderate amounts, just not as much as usually made out. If I wanted direct anti-oxidant effects, personally, id probably stick with foods with the type of nutrients I listed above: liver, eggs (as you point out :)), nuts, oranges, cranberries, kiwifruit etc

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:07 AM

"According to Frei, "we can now follow the activity of flavonoids in the body, and one thing that is clear is that the body sees them as foreign compounds and is trying to get rid of them.""

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:07 AM

However, flavanoids (which I beleive are still polyphenols) - from wiki - "the Linus Pauling Institute and the European Food Safety Authority state that flavonoids, inside the human body, are of little or no direct antioxidant value.[12][13][14] Body conditions are unlike controlled test tube conditions, and the flavonoids are poorly absorbed (less than 5%), with most of what is absorbed being quickly metabolized and excreted."

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:04 AM

I agree that things like choline, E, C, Glutathione, Uric acid, Melatonin and that one in liver that I forget the name of, are body native genuine anti-oxidants.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:01 AM

Plant pigmants are flavanoids, which while arent polyphenols, they are chemically related compounds, and may act in the same way (not sure, havent researched it). But agreed, things like choline, E, C, Glutathione, Uric acid, Melatonin and that one in liver that I forget the name of, are body native genuine anti-oxidants.

08527df7a704aad2ddf12a840abe7963

(164)

on October 03, 2012
at 12:07 AM

Okay, so I did not realize that phytic acid and IP-6 were the same thing (and actually wasn't aware of phytic acid as an anti-nutrient). So after you posted I Googled phytic acid, saw an article on Mark's Daily Apple, read the whole thing and at the end he links to the same study. Full circle. That was wild. Thanks for the info! http://www.marksdailyapple.com/nuts-and-phytic-acid/#axzz28BhIS9Tb

0a9ad4e577fe24a6b8aafa1dd7a50c79

(5150)

on October 02, 2012
at 01:43 PM

Phenols are just 1 group of antioxidants. plant pigments possess antioxidant activity as well (anthocyanins for example.) Choline (eggs are a good source) also has cancer protective properties.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 04:04 AM

If your speaking of polyphenols, which id guess you are, polyphenols do NOT arrest tumor growth, or even act as anti-oxidants in vivo (unlike true antioxdiants like those in beef liver, than actually protect against oxidative damage in vivo). Polyphenols probably work via hormesis ie they are mildy carcinogenic and provide stess like exercise does. By comparison, this compound on the other hand actually seems to arrest tumor growth, which is quite something. Then again, phytic acid also binds minerals, so its a two edged sword..

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:58 AM

Still its very interesting to hear evidence, that the much maligned mineral binding phytic acid might have an upside.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:55 AM

Inositol in the brain is a "secondary messenger system", i wonder does its anticancer properties relate to signalling?

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:54 AM

Wikipedia suggest that we cant digest ip6/phytic acid (and it chelates minerals), but that study suggests otherwise. So I am inclined to beleive the study. Of course, id rather get my phytic acid from nuts, and its potential anti-cancer potential should be balanced with its known mineral chelating properties, making it at best a mixed bag. Its also worth mentioning that inositol can be synthesized in the body from glucose, however possibly not to therapeutic type levels, given studies on high does inositol.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:40 AM

AKA as phytic acid, which binds minerals. Its also present in seeds in high quantities. Inositol itself (which is used in the brain) is present in nuts. Theres also inositol in black tea. Phytic acid tho, binds calcium, magnesium, iron, and zinc which can creat nutritional deficiences.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:30 AM

In fact, as far as IP-6 goes my quick google revealed "inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells.". Seems like neither inositol or ip6 are rare nutrients, and neither would be missing from a paleo diet.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:27 AM

Theres lots of inositol in nuts too.

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3 Answers

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4
Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 04:09 AM

AKA as phytic acid, which binds minerals. Its also present in seeds in high quantities and nuts. Theres also inositol in black tea.

Phytic acid tho, also binds calcium, magnesium, iron, and zinc which can create nutritional deficiences

Wikipedia suggests that we cant digest ip6/phytic acid (and it chelates minerals), but that study suggests otherwise. So I am inclined to beleive the study, which actually presents good evidence.

Of course, id rather get my phytic acid from nuts, and its potential anti-cancer potential should be balanced with its known mineral chelating properties, making it at best a mixed bag.

Its also worth mentioning that inositol can be synthesized in the body from glucose, however possibly not to therapeutic type levels, given studies on high dose inositol.

Inositol in the brain is a "secondary messenger system", i wonder does its anticancer properties relate to signalling?

Still its very interesting to hear evidence, that the much maligned mineral binding phytic acid might have an upside. Its especially interesting to hear of something arresting tumor growth. I was personally unaware that inositol in nuts, and phytic acid were the same thing. Given the widely touted mental benefits of elevated inositol levels (anti-mentall illness, alertness protomiting, cognitive etc), this also makes me see phytic acid in a new light.

Theres alot more research that needs to be done though, before we can intepret this fully..

Such as:

how does those tumor stopping properties effect normal cells? How much phytic acid is required to stop tumors compared to how much is metabolised from food? And how does that balance against the chelating properties - is it possible to get the effect from occasional ingestion of phytic acid rich foods (alone), such as to mediate chelation, or must we ingest alot of it, and in the process get deficiences?

My conservative interpretation of this: A good solid snack on some nuts every now and again might have even more positives going for it. I wouldnt want to go overboard because of chelation. Although there might be something to be said for eating chelating foods alone, or food combining intelligently (such as having nuts with beef to prevent excess iron or zinc).

Food for thought. Thanks for posting, and prompting me into some research..

08527df7a704aad2ddf12a840abe7963

(164)

on October 03, 2012
at 12:07 AM

Okay, so I did not realize that phytic acid and IP-6 were the same thing (and actually wasn't aware of phytic acid as an anti-nutrient). So after you posted I Googled phytic acid, saw an article on Mark's Daily Apple, read the whole thing and at the end he links to the same study. Full circle. That was wild. Thanks for the info! http://www.marksdailyapple.com/nuts-and-phytic-acid/#axzz28BhIS9Tb

1
6120c989fd5b69f42a0834b69b87955b

(24553)

on October 02, 2012
at 03:23 AM

When I was supplementing with inositol, I went searching for direct ways to get it from food and found that chicken and beef heart were pretty darn good sources.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:27 AM

Theres lots of inositol in nuts too.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 03:30 AM

In fact, as far as IP-6 goes my quick google revealed "inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells.". Seems like neither inositol or ip6 are rare nutrients, and neither would be missing from a paleo diet.

1
0a9ad4e577fe24a6b8aafa1dd7a50c79

on October 02, 2012
at 02:54 AM

There are lots of things that prevent cancer. Why would those 2 things be any better than, say, antioxidants found in eggs or berries or blue-green algae or vegetables?

Do those things contain enough benefit to justify eating them for the antioxidants? The answer is generally no.

But fermented grains can be potent sources of probiotics (high-carb=lots of food for the bacteria) and they just taste good. But you can get your anti-cancer nutrients from a million different foods, grains and legumes still aren't necessary.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 02, 2012
at 04:04 AM

If your speaking of polyphenols, which id guess you are, polyphenols do NOT arrest tumor growth, or even act as anti-oxidants in vivo (unlike true antioxdiants like those in beef liver, than actually protect against oxidative damage in vivo). Polyphenols probably work via hormesis ie they are mildy carcinogenic and provide stess like exercise does. By comparison, this compound on the other hand actually seems to arrest tumor growth, which is quite something. Then again, phytic acid also binds minerals, so its a two edged sword..

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 02:53 AM

Oh, coenzyme q10 was the one I was thinking of. I think liver also increases glutathione as well somehow.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:14 AM

Still polyphenols may either increase uric acid (indirect function), or operate via hormesis, so theres still likely benefit to eating them in normal foods, in moderate amounts, just not as much as usually made out. If I wanted direct anti-oxidant effects, personally, id probably stick with foods with the type of nutrients I listed above: liver, eggs (as you point out :)), nuts, oranges, cranberries, kiwifruit etc

0a9ad4e577fe24a6b8aafa1dd7a50c79

(5150)

on October 02, 2012
at 01:43 PM

Phenols are just 1 group of antioxidants. plant pigments possess antioxidant activity as well (anthocyanins for example.) Choline (eggs are a good source) also has cancer protective properties.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:07 AM

"According to Frei, "we can now follow the activity of flavonoids in the body, and one thing that is clear is that the body sees them as foreign compounds and is trying to get rid of them.""

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:01 AM

Plant pigmants are flavanoids, which while arent polyphenols, they are chemically related compounds, and may act in the same way (not sure, havent researched it). But agreed, things like choline, E, C, Glutathione, Uric acid, Melatonin and that one in liver that I forget the name of, are body native genuine anti-oxidants.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:07 AM

However, flavanoids (which I beleive are still polyphenols) - from wiki - "the Linus Pauling Institute and the European Food Safety Authority state that flavonoids, inside the human body, are of little or no direct antioxidant value.[12][13][14] Body conditions are unlike controlled test tube conditions, and the flavonoids are poorly absorbed (less than 5%), with most of what is absorbed being quickly metabolized and excreted."

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on October 03, 2012
at 01:04 AM

I agree that things like choline, E, C, Glutathione, Uric acid, Melatonin and that one in liver that I forget the name of, are body native genuine anti-oxidants.

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