Hi all, just wondering how to minimize ROS. This is a topic I have been able to obtain little info on and would appreciate links to a primer or a good coles-notes version if possible.
asked bypaleohacks (78467)
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on May 12, 2011
at 03:51 PM
There's avoiding PUFAs as best we can for one. Another significant source of ROS is high blood glucose and AGE production, so be sure to attend to metabolic health (paleo diet!)
Probably the best strategy besides avoiding oxidants is to increase antioxidant status. That means obtaining everything we use to make our amazing network of antioxidants from diet. Vitamin c, Vitamin E, selenium, manganese and various amino acids to make superoxide dismutase and glutathione and such. But the thing is that we can make more antioxidants than we actually do, and it takes various foods to increase antioxidant production. There is a supplement called Protandim that mixes a bunch of herbs and spices to drastically upregulate superoxide dismutase production with no obvious side-effects. Some foods and extracts that do this are Green tea (EGCG I think) curcumin, cacao, and some others. http://undergroundwellness.com/good-genes-on/ http://www.ncbi.nlm.nih.gov/pubmed/20368373 There are plenty of others too. Alpha-lipoic acid and silymarin increase heptic glutathione.
I think that smart exercise does this too; sleeping well produces melatonin.
Then we have exogenous antioxidants that last a while in the body and are actively incorporated into cells. Berries have antioxidants that protect the brain, vegetables and eggs have lutein, red meat has carnosene and CLA. Best strategy is to get a wide variety of useful antioxidants.
on May 12, 2011
at 02:58 PM
Excessive accumulation of iron exacerbates ROS formation. See:
If you take a multivitamin, make sure that it is iron free, as you are likely getting more than enough from diet. To deplete your iron stores, Dr Eades recommends donating blood on a regular basis (consider it your good deed for the day).