I am homozygous recessive for MTRR a66g, which is methionine synthase reductase. According to 23 and me i have lots of methylation problems, but none with the MTHFR gene. Does anybody have a good understanding of this and what I should do given this information?
asked byMark_54 (120)
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on May 19, 2013
at 07:20 PM
I also have the MTRR mutation: it's pretty rare. Since this stuff isn't well established, but is based on basic biochemical pathways and as-yet-untested hypotheses, I highly recommend looking into it yourself.
The methylation subforum on phoenixrising is excellent. Specifically, the work of the recently deceased Rich Van Konynenburg is really helpful, particularly if you've been experiencing CFS-type symptoms.
Dr. Amy Yasko has also devoted a lot of time to methylation cycle issues, mostly in the context of autism, and has some good resources on her website. I recommend learning the biochemical pathways involved, but if you don't want to do that, or if you're just looking for preventative care, then supplementing with b12 is a good plan.
Since you don't have the methylation issues associated with methylene-tetrahydrofolate reductase (mthfr) then you may not need to bother with methyl-cobalamin versus cyanocobalamin, but you'll have to check for sure, as I have both MTHFR and MTRR mutations so that's all I've looked into.
A good place to start is the heartfixer site for the pathways: http://www.heartfixer.com/AMRI-Nutrigenomics.htm#MTRR:%A0%20Methionine%20Synthase%20Reductase