3

votes

Polymorphism on the MTRR gene

Answered on August 19, 2014
Created May 19, 2013 at 2:43 PM

I am homozygous recessive for MTRR a66g, which is methionine synthase reductase. According to 23 and me i have lots of methylation problems, but none with the MTHFR gene. Does anybody have a good understanding of this and what I should do given this information?

7841848bd0c27c64353c583fb7971242

(7275)

on May 20, 2013
at 12:10 AM

I went to my nearest doctor's office which has a phlebotomist and asked her to do it for me. Since I had a requisition form (even though it was from Vitamin Diagnostics rather than the clinic) she did it for me.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 19, 2013
at 11:02 PM

Where do I get the blood drawn though?

7841848bd0c27c64353c583fb7971242

(7275)

on May 19, 2013
at 10:09 PM

Also, if you're having methylation symptoms, I highly recommend getting this, admittedly very expensive, test: http://www.seekinghealth.com/methylation-pathway-panel-vitamin-diagnostics.html It actually measures how well your methylation cycle is functioning, so you know, rather than just guessing.

7841848bd0c27c64353c583fb7971242

(7275)

on May 19, 2013
at 10:04 PM

To bring this back on topic for paleohacks: for what it's worth, going paleo didn't seem to help. It required regular dosing of b-vitamins to get me back on track. Weekly servings of liver and the general nutrient rich paleo diet just wasn't cutting it.

7841848bd0c27c64353c583fb7971242

(7275)

on May 19, 2013
at 10:02 PM

No, unfortunately, I couldn't find any practitioners to help. Some doctors are learning about it, but it seems very sporadic, and there doesn't seem to be a way to determine if they know about it ahead of time. I asked my GP and also the university's behavioral medicine people to hook me up with a doctor knowledgeable about CFS or autism, since I thought they might know about methylation, but no luck. The genetics counselors are more about cancer risk, not about methylation stuff. I saw 5 different doctors before I gave up.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 19, 2013
at 09:26 PM

wow. yea i have lots of methylation issues, are there any geneticists that I could make an appointment with to discuss this with? some forward thinking people? Thats cool you figured it out on your own.

  • 5dbc84fc8a8e78e4db7293b58efdde32

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1 Answers

4
7841848bd0c27c64353c583fb7971242

(7275)

on May 19, 2013
at 07:20 PM

I also have the MTRR mutation: it's pretty rare. Since this stuff isn't well established, but is based on basic biochemical pathways and as-yet-untested hypotheses, I highly recommend looking into it yourself.

The methylation subforum on phoenixrising is excellent. Specifically, the work of the recently deceased Rich Van Konynenburg is really helpful, particularly if you've been experiencing CFS-type symptoms.

Dr. Amy Yasko has also devoted a lot of time to methylation cycle issues, mostly in the context of autism, and has some good resources on her website. I recommend learning the biochemical pathways involved, but if you don't want to do that, or if you're just looking for preventative care, then supplementing with b12 is a good plan.

Since you don't have the methylation issues associated with methylene-tetrahydrofolate reductase (mthfr) then you may not need to bother with methyl-cobalamin versus cyanocobalamin, but you'll have to check for sure, as I have both MTHFR and MTRR mutations so that's all I've looked into.

A good place to start is the heartfixer site for the pathways: http://www.heartfixer.com/AMRI-Nutrigenomics.htm#MTRR:%A0%20Methionine%20Synthase%20Reductase

7841848bd0c27c64353c583fb7971242

(7275)

on May 19, 2013
at 10:09 PM

Also, if you're having methylation symptoms, I highly recommend getting this, admittedly very expensive, test: http://www.seekinghealth.com/methylation-pathway-panel-vitamin-diagnostics.html It actually measures how well your methylation cycle is functioning, so you know, rather than just guessing.

7841848bd0c27c64353c583fb7971242

(7275)

on May 19, 2013
at 10:04 PM

To bring this back on topic for paleohacks: for what it's worth, going paleo didn't seem to help. It required regular dosing of b-vitamins to get me back on track. Weekly servings of liver and the general nutrient rich paleo diet just wasn't cutting it.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 19, 2013
at 09:26 PM

wow. yea i have lots of methylation issues, are there any geneticists that I could make an appointment with to discuss this with? some forward thinking people? Thats cool you figured it out on your own.

5dbc84fc8a8e78e4db7293b58efdde32

(120)

on May 19, 2013
at 11:02 PM

Where do I get the blood drawn though?

7841848bd0c27c64353c583fb7971242

(7275)

on May 20, 2013
at 12:10 AM

I went to my nearest doctor's office which has a phlebotomist and asked her to do it for me. Since I had a requisition form (even though it was from Vitamin Diagnostics rather than the clinic) she did it for me.

7841848bd0c27c64353c583fb7971242

(7275)

on May 19, 2013
at 10:02 PM

No, unfortunately, I couldn't find any practitioners to help. Some doctors are learning about it, but it seems very sporadic, and there doesn't seem to be a way to determine if they know about it ahead of time. I asked my GP and also the university's behavioral medicine people to hook me up with a doctor knowledgeable about CFS or autism, since I thought they might know about methylation, but no luck. The genetics counselors are more about cancer risk, not about methylation stuff. I saw 5 different doctors before I gave up.

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