mk-4 not absorbed?

Answered on August 19, 2014
Created February 18, 2013 at 6:15 PM

I know that there is a study praising 45 mg of mk-4 per day but I also came upon this study:


So, maybe mk-4 is useless and the safe bet would be to supplement with all K forms?

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on February 18, 2013
at 07:38 PM

Being the active form, I'd expect MK-4 to be soaked up by various tissues in need of carboxylation immediately. Either that or it may travel via the hepatic portal vein directly to the liver. Though you can attain a stable serum level and positively affect the ratio of carboxylated:uncarboxylated osteocalcin/mgp with mk-7, it's not clear to me that we evolved with large doses of mk-7 "in mind."

Personally, mk-7 triggers arrhythmias for me and I have no idea why. I've seen several others around the net who have similar experiences.



on February 18, 2013
at 06:43 PM

I wouldn't say mk-4 is useless, since several studies have demonstrated it has some effectiveness. I have not myself seen a comparison of the effects of mk-4 and mk-7 on other markers of their effectiveness (uncarboxylated osteocalcin being one) but it is my understanding that mk-7 is more predominately carried in LDL lipoproteins, which spend more time in the blood stream and thus mk-4 will probably be cleared more quickly. So it doesn't surprise me that mk-7 was more readily found in the blood after ingestion. But this doesn't prove to me mk-7 is better, though I do think it seems worthwhile to try getting all forms just to be safe until better research comes out.

Also, the lead other of this study works for J-OIL MILLS, INC, which produces vitamin K2 mk-7. Just a good tidbit to keep in mind.



on February 18, 2013
at 06:47 PM

Nah. MK-4 just has a short half life. Mk-7 hangs around longer. MK-7 might have some good effects too, but the effects of mk-4 on skin alone ought to be a clue that it most certainly does something if you take it in more than 1mg doses per day.

When I tried the plant based K1 stuff I would feel strangely, somewhat like a nervous feeling and my teeth felt weird, so I avoid that stuff.

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