10

votes

Melatonin downregulation?

Answered on August 19, 2014
Created April 09, 2011 at 5:13 PM

If you take melatonin, does your own natural production of melatonin downregulate after a time? if so, how long does it take to screw up your own melatonin? Any idea on where I can read more about this?

Thanks!

Ba99a15e6bf870b81286791617050593

(671)

on September 11, 2012
at 08:53 AM

But a study for 37 days? What about years?

F3fc2e0a9577e7e481a387d917904d1e

(1070)

on December 24, 2011
at 01:59 PM

Care to provide some sources?

5ef574d7893bc816ec52e04139e9bc09

(6097)

on December 15, 2011
at 04:33 AM

^As much as this guy sounds like a dick, I agree.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 08, 2011
at 02:18 AM

AS far as I know (and I have spent real time looking) there is no evidence for your claims. Please either provide evidence or don't post.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 08, 2011
at 02:16 AM

Most certainly, huh? I think it is unacceptable that you respond without evidence. I just spent the past 20 minutes searching pubmed and can't find anything to support this. Please post a link to a study or don't post at all.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 07, 2011
at 11:33 PM

Most certainly, huh? I think it is unacceptable that you respond without evidence? I just spent the past 20 minutes searching pubmed and can't find anything to support this. Please post a link to a study or don't post at all.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 07, 2011
at 11:32 PM

Evidence for your claims?

D5cde8031564f905260ce9aa7a1f5e2c

(1170)

on April 24, 2011
at 01:13 AM

Do you guys have any evidence of this?

667f6c030b0245d71d8ef50c72b097dc

(15976)

on April 09, 2011
at 07:31 PM

Sure. But I'm guessing th rest of us were replying with more average situations I suppose. Glad to hear that you can ameliorate your child's condition with the supplementation though.

D10ca8d11301c2f4993ac2279ce4b930

(5242)

on April 09, 2011
at 06:51 PM

Not all hormones down regulate but yes, melatonin does.

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8 Answers

5
Fbbbdf1d0a7d6d5067a106af062c7ce6

(745)

on December 24, 2011
at 01:17 PM

No, it doesn`t---this seems to be a fairly perpetrated myth.

The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans. Matsumoto M, Sack RL, Blood ML, Lewy AJ. Department of Psychiatry and Neurology, Asahikawa Medical College, Japan. Abstract A physiological dose of melatonin (0.5 mg) or placebo was given at bedtime to night shift workers (n = 21) for seven days, and endogenous melatonin profiles were measured on the eighth day. The amplitude of endogenous melatonin secretion was unchanged by treatment. Also, a melatonin treatment trial using a 50 mg daily bedtime dose for 37 days to a blind subject resulted in no change in the endogenous melatonin profile. We conclude that circulating melatonin can shift the phase, but does not alter the amplitude, of pineal melatonin secretion.

Ba99a15e6bf870b81286791617050593

(671)

on September 11, 2012
at 08:53 AM

But a study for 37 days? What about years?

1
Medium avatar

on December 24, 2011
at 05:31 PM

Even if taking M causes downregulation, I don't mind. Because I'm over 50 and my body produces less on its own than in the past, so I don't mind supplementing to get the full nighttime effect, even for the rest of my life. I find that if I happen to forget to pop my M supplement for a few or even several nights in a row, my sleep is still good. so I don't seem to be M dependent. Going to bed calm helps. Getting calm is the key. Meditation, proper internal dialogue. Stop stressful mind chat.

In general I am positive toward hormone replacement, with two factors in mind. First, do everything you can to naturally optimize endogenous hormone levels. Second, a balanced, informed approach is crucial. For instance, if you're a guy and go for exogenous testosterone replacement, it can kick up estrogens big time. Not good; opposite of what you want.

1
34a367e60db77270bd7096dc04270fdc

(4171)

on April 09, 2011
at 06:32 PM

Do we know this for sure? Some people produce less Melatonin than average - my son with autism has always had trouble getting to sleep, his pediatrician suggested 1-3mg in the evening to help him get to sleep. He doesn't take it anymore except for rare occasions when he has trouble getting to sleep but isn't it possible that some people might be deficient and taking a supplement would bump it up to a normal level?

667f6c030b0245d71d8ef50c72b097dc

(15976)

on April 09, 2011
at 07:31 PM

Sure. But I'm guessing th rest of us were replying with more average situations I suppose. Glad to hear that you can ameliorate your child's condition with the supplementation though.

0
21f4cf08537107cd06ca2cd4f9ac0fc9

on March 23, 2012
at 06:00 PM

Good info on melatonin can be found at 'sahelian-melatonin'. This is a very good reference & research site by Ray Sahelian,M.D. who dosen't "tow the line" with the AMA,neither does he throw science out the door. The key is "excessive dosage & prolonged use". I personally have used a vegie source of melatonin at very low dosage, .3mg, with good results although I am very sensitive to most supplements anyway.Humans are currently undergoing an onslaught of electro "down regulation" in general from multiple sources. We live in electrified boxes wrapped in wires & expose ourselves to constant EMF producing sources,one of which I am using now from which I suffer neuropathy,low immune function,etc. Externally we are in the cross fire of microwaves,radar,etc. A mad consumer driven experiment. There are huge amounts of info on EMF's & is not the topic here. Sorry if I digress off topic.

0
64433a05384cd9717c1aa6bf7e98b661

(15236)

on April 09, 2011
at 10:27 PM

I feel a difference if I take it more than 2 nights in a row. It does work great for jet lag however.

-3
667f6c030b0245d71d8ef50c72b097dc

(15976)

on April 09, 2011
at 06:30 PM

everything i've read says that it would indeed downregulate your own production if you continually use it. here and there i wouldnt think would be an issue.

F3fc2e0a9577e7e481a387d917904d1e

(1070)

on December 24, 2011
at 01:59 PM

Care to provide some sources?

-3
7fe08b47d7d073a906802a4170ae24bf

(350)

on April 09, 2011
at 06:26 PM

It most certainly does down regulate your own bodies production of melatonin. I only take it on rare occasion, if I'm having trouble sleeping or adjusting from time change from an international trip.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 08, 2011
at 02:16 AM

Most certainly, huh? I think it is unacceptable that you respond without evidence. I just spent the past 20 minutes searching pubmed and can't find anything to support this. Please post a link to a study or don't post at all.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 07, 2011
at 11:33 PM

Most certainly, huh? I think it is unacceptable that you respond without evidence? I just spent the past 20 minutes searching pubmed and can't find anything to support this. Please post a link to a study or don't post at all.

5ef574d7893bc816ec52e04139e9bc09

(6097)

on December 15, 2011
at 04:33 AM

^As much as this guy sounds like a dick, I agree.

-3
77877f762c40637911396daa19b53094

(78467)

on April 09, 2011
at 05:23 PM

Yes, it down regulates your own production of melatonin. It's a hormone.

D10ca8d11301c2f4993ac2279ce4b930

(5242)

on April 09, 2011
at 06:51 PM

Not all hormones down regulate but yes, melatonin does.

D5cde8031564f905260ce9aa7a1f5e2c

(1170)

on April 24, 2011
at 01:13 AM

Do you guys have any evidence of this?

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 08, 2011
at 02:18 AM

AS far as I know (and I have spent real time looking) there is no evidence for your claims. Please either provide evidence or don't post.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on May 07, 2011
at 11:32 PM

Evidence for your claims?

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