I came across this study linking low-carb diets to cardiovascular disease in reading Robert Lustig's new book.
asked byHenry_Duran (10)
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on April 03, 2013
at 11:08 PM
http://www.pnas.org/content/106/36/15418.full Vascular effects of a low-carbohydrate high-protein diet
" the macronutrient changes in the LCHP diet used here mimic the diets commonly used in humans, where reduced carbohydrate intake is generally accompanied by increased protein and fat intake. Interestingly, multiple results in mice on the LCHP diet paralleled those reported in clinical trials including reduced weight gain without significant changes in serum lipids or other markers of cardiovascular risk (10, 11), further reinforcing the potential relevance of this model.
Exacerbated atherosclerosis occurred on the LCHP diet independent of significant alterations in traditional atherogenic serum lipids, serum inflammatory markers and histological indicators of inflammatory infiltration. We did detect a significant increase in serum NEFA levels on the LCHP diets (Table 1) but this was not correlated to an increase in serum measures of inflammation. Importantly, there was no evidence of increased leukocyte infiltration in plaques from mice on the LCHP diet. We did not detect a significant difference in either circulating oxLDL or tissue markers of oxidative stress. Together these data suggest that neither an increase in the inciting signals nor in the inflammatory cascade are responsible for the increased atherosclerosis seen on the LCHP diet when compared with the similarly high-fat WD.
Although caution is warranted in extrapolating from such animal studies, these data at least raise concern that low-carbohydrate high-protein diets could have adverse vascular effects not adequately reflected in serum risk markers. Moreover, these observations demonstrate important pathophysiological vascular effects of nonlipid macronutrients that are dissociated from weight gain. These features provide a unique model for understanding mechanisms of atherogenesis and neovascularization that may have implications for efforts to combat obesity and reduce its complications."
http://mygreendiet.com/wp-content/uploads/2010/02/2286.pdf A Look at the Low-Carbohydrate Diet
"Traditionally, the atherosclerotic risk profile that is associated with specific diets is determined by measuring intermediate risk factors, such as levels of low-density lipoprotein cholesterol, blood pressure, and C-reactive protein. The work of Foo et al. suggests that the HPLC diet might increase the risk of cardiovascular disease through mechanisms that have nothing to do with these ???usual suspects??? and so provides a note of caution against reliance on the traditional cardiovascular risk factors as a gauge of safety."
SO - shouldn't we be a little concerned??