5

votes

leptin receptors

Answered on August 19, 2014
Created July 26, 2011 at 4:46 PM

While doing research about leptin, there is a lot of information, studies and theories on how leptin interacts with the receptors in the hypothalamus to throw off the satiety meter and get the ball rolling on all types of nasty maladies. What there seems to be less information, studies and theories about are the leptin receptors on the muscles and organs(particularly the liver and pancreas).

Are the receptors on the muscles and organs disregulated by the same mechanisms as the the receptors in the hypothamus(high omega 6/3 ratio, fructose, lectins)?

Do the receptors in the pancreas regulate beta cell production of insulin and is faulty receptors the reason that beta cells die off in diabetics?

Do the leptin receptors in the muscle determine skeletal muscle insulin resistance?

Do the leptin receptors in the liver control hepatic insulin resistance?

It seems that in all the places that insulin resistance originates there also seems to be leptin receptors there. How is it that leptin seems to be the kingpin but the street thug insulin always gets heat from the obesity cops?

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on July 26, 2011
at 06:49 PM

Yes it does screw beta cells too.

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on July 26, 2011
at 06:48 PM

This is why protein folding fails. Receptors fail the same way. Especially thyroid and leptin. This is why I go nuts for hs crp and fasting postprandial glucose levels and the omega six three ratio

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on July 26, 2011
at 06:47 PM

Not just oxidation.....glycation too!

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on July 26, 2011
at 05:23 PM

so does it send signals to the beta cells? does it determine skeletal muscle insulin resistance? i'm curious as to the signaling mechanism... how does the faultiness of the receptor impede that...

66e6b190e62fb3bcf42d4c60801c7bf6

(12407)

on July 26, 2011
at 05:19 PM

thanks, quilt. i've read both of your posts on it. so oxidation of the receptors is what makes them faulty?

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on July 26, 2011
at 05:08 PM

The key is proteomics adaptions at receptors caused by foods that allow it. I went through some this in my two AD blogs because it appears that is precisely how hormone receptors are damaged and why levels don't matter in some cases. Omega sixes really cause it due to lipid per oxidation. Fructose too.....

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on July 26, 2011
at 05:06 PM

There are leptin receptors everywhere......even your tastebuds

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1 Answers

4
D1c02d4fc5125a670cf419dbb3e18ba7

on July 26, 2011
at 05:03 PM

LB,

Leptin was discovered in 1994 and Insulin back in the 1950s (I think). Without getting into the biochemistry of your question, I view it similar to the fixation with cholesterol.

For 50 years now we have been developing, refining, attacking, attempting to falsify the lipid hypothesis and still continue to do so because of inertia, which is VERY difficult to overcome. Not sure if it will ever be overcome in my lifetime.

I think as the role of leptin continues to be clarified, including causal vs correlative factors, this might change.

In the meantime, I will continue to

  • Avoid gluten
  • Avoid excess fructose
  • Avoid excess O-6
  • Avoid soy and problematic legumes
  • Try to get adequate sleep (but failing miserably given the PH addiction)
  • Still my mind (even more of an issue than the previous point given the orthorexic tendencies)

Ok back to work...Seacrest, out

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