1

votes

Dr. K's leptin reset and metformin

Answered on August 19, 2014
Created October 21, 2011 at 12:45 PM

I'm about to embark headfirst into Dr. K's leptin reset due to the fact that I've been steadily gaining weight and exhibit many of the LR symptoms. I have PCOS and am probably insulin resistant. My basic take on the leptin reset is that if you correct the LR the IR will follow. I'm currently taking low-dose Metformin (500 mg) and I'm wondering if this will interfere with my body resetting itself. Should I hold off or take it at a specific time?

A little background info- 25 y/o female, PCOS, 142 lb, was happily at 125 for a while then went on birth control to "cure" my amenorrhea, packed on 15 lbs in 2 months and have not been able to lose it. Amenorrhea returned after I quit the pill, my doctor put me on Metformin in attempt to manage PCOS. I might as well be taking a placebo, I notice no difference.

Cc69a51b427eaad36251cce9dcca4d3a

(1074)

on March 05, 2013
at 10:22 AM

try to make sure the protein is high. dr. kruse's own macro ratio is ~50f/40p/10c.

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on November 06, 2011
at 10:12 PM

Metformin has many surprising good effects.....mimics CRON and it increases AMPk, and effects Glut transporters but I still want people off of it asap. The reset can do that.

77877f762c40637911396daa19b53094

(78467)

on October 21, 2011
at 02:31 PM

It looks like metformin is safe drug. Its even use as supplement by many people, especially since LEF promoted it: http://www.lef.org/magazine/mag2001/sep2001_report_metformin_01.html. I am not sure that anything that directly interferes with how liver works is good idea.

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on October 21, 2011
at 12:51 PM

Keep us informed about how you progress. The reset will help pcos

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6 Answers

1
6120c989fd5b69f42a0834b69b87955b

(24553)

on November 07, 2011
at 07:26 PM

If you are concerned, you could swap out NAC (N-Acetyl-Cysteine) for your Metformin. I have no idea what effect Metformin will have on the Leptin Reset, but for women with PCOS, NAC outperformed Metformin and didn't have the side effects or price tag.

http://www.ovarian-cysts-pcos.com/pcos-news140.html#sec1

1
59ee717de524f921efb7f2984157339f

on November 07, 2011
at 05:41 PM

Raspberry....I am in a very similar situation as you...PCOS constantly gaining...I am trying to the Leptin Reset as well...Could you share your progress and routine...ie. what you eat...at what time...and what you have noticed so far?

Thanks!

1
64433a05384cd9717c1aa6bf7e98b661

(15236)

on November 06, 2011
at 03:52 PM

The article was good but pretty vague about how it worked. It originated from phytonutrients in french lilac. From my understanding, aside from increasing insulin sensitivity, it also

  • causes a decrease in hepatic glucose production via gluconeogenesis,

  • increases peripheral (ex skeletal muscle) utilization of glucose,

  • appears to increase the translocation of GLUT transporters to the cell surface

It leads to AMPK activation which is associated with inhibition of lipogenesis because it inactivates acetyl CoA carboxylase (ACC) and suppresses lipogenic enzyme expression. AMPK activation is also required to suppress glucose production in hepatocytes.

This relates closely to Dan Atkinson's theory of Adenylate energy charge

http://pubs.acs.org/doi/abs/10.1021/bi00851a033

0
E4009900e841a50046bd36d897f09f25

on March 05, 2013
at 09:49 AM

I'm in a similar boat 142, and doing the LRP with PCOS. Ive been doing it for 3 weeks now and had one day last week where I didnt stick to the protocol so I guess I am back where I started. I haven't lost any weight yet - but I haven't gained so I guess that's better than nothing....

Cc69a51b427eaad36251cce9dcca4d3a

(1074)

on March 05, 2013
at 10:22 AM

try to make sure the protein is high. dr. kruse's own macro ratio is ~50f/40p/10c.

0
4ef079c57d2140bba4dbf4e30240a645

on June 21, 2012
at 02:19 AM

How are you doing on the Metformin? Im considering it myself. Would be great to hear some followup. Im unclear how to ask for that other than in this Answer box. I understand this is a question not an Answer :)

If anyone has advice on how to ask for follow up in a better way... Im all ears.
Thank you.

0
Dbe5290b790e6e2d2bd59d581d9cf164

on November 06, 2011
at 05:05 PM

*Neoglucogenesis

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