After having given Jack's seemingly inexplicable lipid panel some thought, I think I may have figured out what occurred. Because Jack has very little body fat, he is broadcasting a fairly weak leptin signal to his hypothalamus. Under normal circumstances, this wouldn't be a problem and no red flags would be raised. However, with the introduction of a relatively small amount of fructose, I believe that Jack spiked his VLDL and thus serum triglycerides via de novo lipogenesis in the liver. Because of how little circulating leptin there is, it didn't take much in the way of triglycerides to block leptin's passage across the blood-brain barrier. Suddenly, the hypothalamus thinks that Jack's body fat has somehow plummeted and he's starving to death. The hypothalamus then upregulates de novo lipogenesis and triglycerides rise further. These triglycerides then further cement the simulated starvation as viewed by the hypothalamus. Only with an intervention like the one I described in the aforementioned post can this cycle be interrupted and VLDL/TGs be cleared from circulation.
It would seem that with regard to lowering serum triglycerides, people with more fat mass actually have an advantage due to the greater strength of their leptin signalling. It's a novel theory, anyway.
asked byTravis_Culp (39831)
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on September 16, 2011
at 03:50 PM
WOAH, steak determines your entire body process of eating and balance? appetite is a process, a BIG and LONG process, not a feeling post steak gorging. it is lots of signals, lots of hormones, lots of everything and a lot we do not know. your hypothalamus is more centric on what your thinking and feeling in relation to your life, your sleep etc.
you can 'tell' yourself a lot. for example, i can eat 16 oz of steak and not eat again for 2-3 days just because i can tell myself to disregard hunger(which is a feeling i dont feel anyways) but that doesnt mean my hypothalamus isnt acting in opposition to that or that there are 100 other detrimental things going on elsewhere in my mind and body when i dont eat for 2-3 days.
i need some clarification where your coming from on this... please, cuz youre a lot smarter than I haha
on September 16, 2011
at 03:00 PM
Why ghee, wouldnt it better to have only coconut? and perhaps marrow fat ;) I have these unoptimal lipids too, i ditched all dairy stuff, and doing coconut only. I propably have leaky gut. I like coconut for my vegs but perhaps i will reorder a large batch of some duck fat. I use beef marrow fat too. I get free marrow bones. And tomorrow i will recieve a lambs head which i will roast. Will be wild thing to prepare in kitchen. Next month reindeer from Lapland... Little steep for my income tho, :(