2

votes

Chemical composition of Immunglobulin A (IgA) ?

Answered on August 19, 2014
Created December 17, 2011 at 11:36 AM

Hi,

I just read the lectin story (http://www.krispin.com/lectin.html) and noticed that IgA is actually the guts defense machanism to protect us from lectin damage. So I was wondering which foods I can eat to give my body the optimal building blocks to produce enought IgA. As I am prone to developing food allergies, I suppose that my IgA levels are really low and maybe the key is to support my body rebuild its defense. Does anybody know, which chemical compounds such an Immunglobulin consists of? Since it binds to lectins it should have some kind of sugar attached, such as glucosamine? WHat supplements can you suggest to support IgA production?

Thanks!

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on March 02, 2012
at 06:28 AM

Amazing! Thank you! :)

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 18, 2011
at 09:33 PM

I just read that in Traditional Chinese Medicine the shiitake mushroom is said to be curing for the immune system. Also it is stated on another page that it contains a fair amount of N-Acetyl-Glucosame... interesting coincidence. There might be some truth behind it.

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 18, 2011
at 09:29 PM

Thanks! The picture is getting clearer to me. Seems that I just have to avoid any allergens and the lion's share of lectins in my diet and wait for my gut to heal. ANd once this has been accomplished, IgA and it's little friends will do their job as good as possible. There are many reports of people who were able to tolerate many foods again after a year of avoidance. Great!

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 18, 2011
at 09:21 PM

Great, so I will get me some glucoasamine. I eat no fruit, nuts, eggs, beef, (& grains, dairy, legumes, nightshades) and therefore really low carb. The only starch I get, is from the vegetables (carrots, brussel sprouts, cauliflower, broccoli, spinach, etc.) and sometimes a sweet potato. And although I'm not trying to lose weight, I feel great to be in ketosis every now and then. I use a lot of lard and goose fat, eat lots of poultry, pork, wild salmon, shellfish and the like. It's a bit boring but completely okay, since carbs give me gas and nuts diarrhea. Hope this improves somewhen.

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 18, 2011
at 01:32 PM

I see. Can't be bad to take glucosamine, you should feel the difference if you are right. What do you eat basically?

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 18, 2011
at 01:31 PM

I see. What do you eat basically?

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 17, 2011
at 10:23 PM

Thanks for your comprehensive answer! I'm allergic to dairy, soy and beef and even peas, which are considered somewhat safe, give me digestive issues. Coconut doesn't work for me either. As soon as I don't strictly stick to the "autoimmune paleo plan" without nuts, eggs etc. my stomach goes haywire. SInce all those food groups contain a fair amount of lectins I was assuming that they are the culprit. Unfortunately other foods contain lectins too, so I wanted to protect my gut from them.

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 17, 2011
at 09:46 PM

see answer above.

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 17, 2011
at 08:23 PM

Well the way I understood it, is that IgA actually binds lectins (like glucosamine as you say) and neutralizes them so they can do no harm to the gut wall. Hence, it would be positive to have a high amount of them, wouldn't it? In the meantime I looked for a glucosamine supplement, but there seems nothing that has no fillers, preservatives and additives.. really frustrating, can anybody suggest a glucosamine supplement?

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 17, 2011
at 01:30 PM

they are glycoproteins. proteins (chains of amino acids) with a sugar attached.

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 17, 2011
at 01:29 PM

they are glycoproteins. Proteins with a sugar attached.

  • E2b72f1912f777917d8ee6b7fba43c26

    asked by

    (2384)
  • Views
    1.9K
  • Last Activity
    1429D AGO
Frontpage book

Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!

6 Answers

best answer

2
Ec7cb2a7a68655954a01f03e95be1383

on December 17, 2011
at 01:45 PM

They are glycoproteins. Proteins (chains of amino acids) with a sugar attached.

I don't know much about immunology but as a layman I would suspect that your body doesn't have any problems manufacturing antibodies out of some amino acids and sugar if they are needed. Why would you want your body buildung antibodies if you don't need an immune reaction? I think it wouldn't be positive in every case to have a higher IgA production. At least if there is no assault on your immune system.

If you want to be protected from lectins, don't eat those foods with most lectins in it. And yes, glucosamine is good because it binds to lectins in the intestine before they can attach to the intestinal lining.

*Edit:

I think you confused cause and effect. Low IgA is either due to genetics or environment (environmental poisons, dietary toxins like lectins, PUFA, sugar). And, as statet in the lectin report, "Bacteria, virus, or other conditions, drugs or injurious substances acting directly on the gut wall may cause sensitization." So basically there are things which damage the gut, leading to compromised IgA production. The only way you can activate your natural immune response is by healing your body, especially the intestine. It is not that your body is missing the building blocks to build antibodies but it just doesn't feel like it should produce them.

Optimizing your diet is one way, another would be stress reduction and maybe professional detoxification of environmental chemicals and metals.

In the meantime, if you are concerned with lectins, a glucosamine supplement combined with a lectin-poor diet should be enough. Have a look into the products from Pure Encapsulations.

Btw, what do you think lectins have done to your health and why isn't it enough to just avoid them?

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 18, 2011
at 01:32 PM

I see. Can't be bad to take glucosamine, you should feel the difference if you are right. What do you eat basically?

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 17, 2011
at 09:46 PM

see answer above.

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 17, 2011
at 10:23 PM

Thanks for your comprehensive answer! I'm allergic to dairy, soy and beef and even peas, which are considered somewhat safe, give me digestive issues. Coconut doesn't work for me either. As soon as I don't strictly stick to the "autoimmune paleo plan" without nuts, eggs etc. my stomach goes haywire. SInce all those food groups contain a fair amount of lectins I was assuming that they are the culprit. Unfortunately other foods contain lectins too, so I wanted to protect my gut from them.

Ec7cb2a7a68655954a01f03e95be1383

(1453)

on December 18, 2011
at 01:31 PM

I see. What do you eat basically?

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 17, 2011
at 08:23 PM

Well the way I understood it, is that IgA actually binds lectins (like glucosamine as you say) and neutralizes them so they can do no harm to the gut wall. Hence, it would be positive to have a high amount of them, wouldn't it? In the meantime I looked for a glucosamine supplement, but there seems nothing that has no fillers, preservatives and additives.. really frustrating, can anybody suggest a glucosamine supplement?

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 18, 2011
at 09:33 PM

I just read that in Traditional Chinese Medicine the shiitake mushroom is said to be curing for the immune system. Also it is stated on another page that it contains a fair amount of N-Acetyl-Glucosame... interesting coincidence. There might be some truth behind it.

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 18, 2011
at 09:21 PM

Great, so I will get me some glucoasamine. I eat no fruit, nuts, eggs, beef, (& grains, dairy, legumes, nightshades) and therefore really low carb. The only starch I get, is from the vegetables (carrots, brussel sprouts, cauliflower, broccoli, spinach, etc.) and sometimes a sweet potato. And although I'm not trying to lose weight, I feel great to be in ketosis every now and then. I use a lot of lard and goose fat, eat lots of poultry, pork, wild salmon, shellfish and the like. It's a bit boring but completely okay, since carbs give me gas and nuts diarrhea. Hope this improves somewhen.

2
518bce04b12cd77741237e1f61075194

(11577)

on December 17, 2011
at 10:32 PM

Yeah, IgA is not something that you eat and your body just assimilates it from other sources. It is manufactured by you, for you. Your immune system will function optimally when you are in your best health, regardless of whether the "building blocks" are available or not (ie. if you consume a lot of calories in a SAD diet, you will have plenty of amino acids, sugars, fats, but if you are not healthy you aren't going to be able to build up an effective immune system response).

All antibodies are produced by white blood cells, and each one has it's own funciton to carry out. IgA has to do with the gut because it is present in mucosal areas (respiratory, gut, urogenital, saliva, tears, breast milk). There are many other antibodies (IgD, IgE, IgM, IgG) each with their own specific function. As far as my knowledge extends (two years of microbiology, immunology, and virology before I switched my major), you are not going to discriminately synthesize one Ig over another, except for in response to your environment (ex, exposed to pathogens in the gut, you will up your production of IgA, but if you are exposed to an allergen, you will up your production of IgE).

I think any supplement or product that would claim to individually enhance the production of a specific antibody is probably bogus. The best thing to do is optimize your health, then your immune system will follow.

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 18, 2011
at 09:29 PM

Thanks! The picture is getting clearer to me. Seems that I just have to avoid any allergens and the lion's share of lectins in my diet and wait for my gut to heal. ANd once this has been accomplished, IgA and it's little friends will do their job as good as possible. There are many reports of people who were able to tolerate many foods again after a year of avoidance. Great!

1
F26fbc92b18f4689769d6f8746ea40f7

(334)

on November 13, 2012
at 11:02 PM

I am an immunologist :)! As said above, Immunoglobulin A (or IgA) is a glyco-protein. If you eat enough protein, there would be no obvious bottle-neck in its production. However the cells that produce IgA, B lymphocytes that home to the gut, can be triggered to produce more or less of it. The key is to keep your gut healthy. Taking probiotics wouldn't hurt, although it's debatable how much of it really reaches and (re-)populates your gut. Avoid known allergens, as those would create a pro-inflammatory environment by increased the permeability of the gut lining and overactivate your immune system. What you need to know is that you won't be able to control the specificity of the IgA produced (except by voluntarily triggering an immune reaction by ingestion a immunogenic, foreign substance).

1
549b368f0081ae1dde28d2c33ed5b759

on March 01, 2012
at 09:14 PM

I just ran across this post so am really late.. Hope you see this :)

Probiotics (not sure which though) stimulate the body to produce IgA by B cells.

Check out page 8 of the following link http://www.horizonpress.com/cimb/v/v10/05.pdf

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on March 02, 2012
at 06:28 AM

Amazing! Thank you! :)

1
E714eead86af8f8fc4cfbe8831f767a4

on December 21, 2011
at 06:33 AM

This is really interesting take on the concept. I never thought of it that way. I came across this site recently which I think it will be a great use of new ideas and informations. Thanks a lot...

0
305f4c060814a6a87ae72afd7e661318

on November 13, 2012
at 01:33 PM

You know i dont know if anyones willing to explore or entertain my argument but theres got to ne more to allergy than avoid a certain food. The world was built on logic. And every little thing can be measured. At least the little things we know of anyway. Basically an allergic reaction is the body.calling something a threat. So it attacks. What is the reason that it attacks? It wont attack something healthy. There must be some kind of micro going ons were missing. Esp not something weve been exposed to all our lives. Essenfially allergic reactions happen because our gut is compromised. So how do you help your IgA? 1keep your acid alkaline levels right. Keep your probiotic levels highand ballanced. Avoid contamination at all as much as possible. I dont believe in de germing everything ballanced life needs something to build on. But if you are compromised you need to need to be careful. That all basically comes down to wash and peel your veggies. Wash your hands. Wash your meat but be dont over consume it. Protein is high energy and obesity also compromises immunity. Washeverything. Be sure. Now the peeling bit is my question. Allergies are on the rise inspite of todays resorces. But everything has antibiotics and pesticides in it. Is it not the synthetics were reacting to( i recently became allergic to crustacians, my favourite food group )now synthetics are most definately foreign bodies. And the skins are where the fruit and veg store their food from the soil. Which now days is not much more than antibiotics and pesticides. So hence i say peel them. My daily routine. A teaspoon of.epsom salts before anything else in a glass of warm water cos its easier to swallow and less of a shock to the body than cold. This flushes your.system. Wait 5-10 mins. Probiotic suppliment with belgium yoghurt. Iv heard most commercial yoghurts dont do the trick. Thats hearsay. Either way its my own oppinion and own choice. With a teaspoon of glutamine. And thus you have given your body a kickstart defence. There are studies that say this meathod has cured as much as schitzophrenia. Wish i cohld find that article again! Obviously in doing this its pointless not being careful about what else your putting in your system. So my question is... Is anyone out there prepared to put the books down and forget theory . Cos we all know the basics and whats accepted science. Move forward with me and look at the logic of how life was created. And ansaer the question- what causes an allergic reaction? I dont like substituting in life just so i wont unwittingly suffocate in my sleep. I dont think anyone else wants to either.

Answer Question


Get FREE instant access to our
Paleo For Beginners Guide & 15 FREE Recipes!