5

votes

Leaky Gut study... anyone want to take a crack at it?

Answered on September 12, 2014
Created November 10, 2011 at 12:06 AM

http://www.ncbi.nlm.nih.gov/pubmed/19112401

Can anyone see what the "leaky gut diet" was that worked after 10-14 months along with NAC, glutamine, and Zinc supplementation. This seems like a relatively low key approach to what many seem to do for it.

Anyone got access to the full study?

3864f9a2af09b1b447c7963058650a34

(3703)

on November 11, 2011
at 08:39 AM

Is the information helpful? Do you find it adding to your knowledge? Thanks for eyes!

3864f9a2af09b1b447c7963058650a34

(3703)

on November 11, 2011
at 08:38 AM

Sharp eyes -- sorry it should be 'inulin' on the original source. Some people have worse symptoms (bloating) with probiotics and inulin/FOS/fiber/veggies. Their SIBO is severe and they need to calm things down before being able to add these to the program.

6120c989fd5b69f42a0834b69b87955b

(24553)

on November 10, 2011
at 06:17 AM

Just to be clear, did you mean "inulin" instead of "insulin" for prebiotics?

1c67bc28f4e44bbb8770b86df0463df3

(6719)

on November 10, 2011
at 05:00 AM

First of all, it is highly unlikely that someone has full blown 'leaky gut syndrome'. Second, in order to make it better, consume 8-10 grams of L Glutamine a day for 10 days. Should be good to go after that.

7dc950fc76a046048e683d2a27dced37

on November 10, 2011
at 01:02 AM

Yeah. On her blog, Emily says she emailed the author to get more info about the diet but the email to the address provided bounced.

0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on November 10, 2011
at 12:58 AM

Not very informative though.

0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on November 10, 2011
at 12:54 AM

I knew I had read the full text somewhere before :)

0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on November 10, 2011
at 12:31 AM

That is the least accessible paper I have ever seen.

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4 Answers

4
7dc950fc76a046048e683d2a27dced37

on November 10, 2011
at 12:38 AM

Google Scholar to the rescue: paper is here. But the full paper isn't that helpful. The diet is described as a "a milk allergic, gluten-free and low-carb diet" (top of p 103).

Emily Deans has a discussion of the case study that preceded this paper on her blog.

7dc950fc76a046048e683d2a27dced37

on November 10, 2011
at 01:02 AM

Yeah. On her blog, Emily says she emailed the author to get more info about the diet but the email to the address provided bounced.

0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on November 10, 2011
at 12:58 AM

Not very informative though.

0bc6cbb653cdc5e82400f6da920f11eb

(19245)

on November 10, 2011
at 12:54 AM

I knew I had read the full text somewhere before :)

1
3864f9a2af09b1b447c7963058650a34

(3703)

on November 10, 2011
at 04:56 AM

In integrative medicine there are the 4 R's (there's actually 7 now! but let's stick to old time basics):

Treating the overall gut, with exclusion or rotation diets, glutamine, fish oils for inflammation, and the entire 4-R program includes:

Treatment Using Four ???R??? Program for Intestinal Health:

??? Remove offending foods, medications, gluten (if sensitive) and reduce high fat foods, refined carbohydrates, sugars, and fermented foods (if yeast is present). Consider antimicrobial, antifungal, and/ or antiparasitic therapies in the case of opportunistic/ pathogenic bacterial, yeast, and/or parasite overgrowth (see otherrecommendations below).

??? Replace what is needed for normal digestion and absorption such as betaine HCl, pancreatic enzymes, herbs that aid in digestion such as deglycyrrhizinated licorice and marshmallow root, dietary fiber, and water.

??? Reinoculate with favorable microbes (probiotics such as Lactobacillus sp., Bifidobacter sp., and Saccharomyces boulardii). To enhance the growth of the favorable bacteria, supplement with prebiotics such as insulin, xylooligosaccharides, and fiber.

??? Repair mucosal lining by giving support to healthy intestinal mucosal cells, goblet cells, and to the immune system. Consider L-glutamine, essential fatty acids, zinc, pantothenic acid and vitamin C.

Other Recommendations for Increasing sIgA

??? Exercise and relaxation techniques (such as footbaths, aromatherapy and massage) have been shown to increase sIgA levels.

??? Decrease cortisol levels. Cortisol can direct the production of immune cells immuncytes, which produce sIgA.Probiotics (bifidobacter and Lactobacillus bacteria) have been shown to increase sIgA (as well as beneficial short chain fatty acids). They may also activate macrophages.

??? Saccharomyces boulardii is used for the prevention and treatment of diarrhea of different etiologies and has been shown to enhance IgA immune response

http://www.metametrix.com/files/learning-center/articles/Secretory-IgA.pdf

3864f9a2af09b1b447c7963058650a34

(3703)

on November 11, 2011
at 08:39 AM

Is the information helpful? Do you find it adding to your knowledge? Thanks for eyes!

6120c989fd5b69f42a0834b69b87955b

(24553)

on November 10, 2011
at 06:17 AM

Just to be clear, did you mean "inulin" instead of "insulin" for prebiotics?

3864f9a2af09b1b447c7963058650a34

(3703)

on November 11, 2011
at 08:38 AM

Sharp eyes -- sorry it should be 'inulin' on the original source. Some people have worse symptoms (bloating) with probiotics and inulin/FOS/fiber/veggies. Their SIBO is severe and they need to calm things down before being able to add these to the program.

1
9d8b1ca66aba8d9fa784689c222615c6

on November 10, 2011
at 02:29 AM

I have great success following the suggestions and supplements in "Restoring Your Digestive health" by J S Rubin, NMD and J Brasco, MD. Very Paleo and very simple and very quick. Published 2003 and easy to find used on Amazon.

0
68f2734a5078a7106f560a7079df45fd

on November 10, 2011
at 02:38 AM

"...consisting of milk allergic, gluten-free and low-carb diet.". Looks like a low carb paleoish diet.

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