The oft-repeated maxim in Paleo/Primal seems to be that LDL numbers don't really matter. Get an actual, not calculated count and look at the particle size, it is said, but if the particles are large, you're "ok".
I realize that not everybody says this, but it is certainly repeated often and seems to be the "lay" understanding. It seems to me that the other qualifiers to this statement should be something more like "LDL doesn't matter as long as you're not seeing inflammation/high CrP numbers, you're not under much stress, not smoking, getting exercise and good sleep." Point being, if you have high LDL and high CrP, then you should be fixing one or both, right?
asked byJason_25 (0)
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on May 07, 2012
at 10:16 PM
Oxidized LDL is probably the major culprit in atherosclerosis. If you have a huge LDL pool, it's more likely that more of it will become oxidized. This is possibly due to things like endothelial injury, low LDL receptor activity, recent body fat loss, or some people have a hypercholesterolemic reaction to certain fat balances as well. LDL particle number (high) and particle size (small) are measurements that correlate with high oxLDL.
If your LDL is high even in itself, it's worth looking into the cause. It could be more benign or be a concern.