6

votes

Neural effects of ketosis?

Answered on August 19, 2014
Created December 28, 2011 at 4:07 PM

Hi,

there are quite a few sources, which state the benefits of ketosis on the nervous system. E.g. as a treatment for epileptics, to reduce the severity and frequency of their seizures. Interestingly, ketosis seems to change a lot in the way our brains are working.

I always experienced difficulties to stay focused while in the lectures at the university, but now that I'm in ketosis for a few weeks, it seems that my mind has become much clearer. Like drinking a bottle of green tea right before the lecture... save that I didn't. (Besides, it would be really annoying to race to the restroom 5 times during the lesson :D )

Can anybody confirm my observations? And the even more interesting question: Who knows papers, studies etc. which focus on the neural effects of ketosis?

Thanks!

0d0842381492a41b2173a04014aae810

(4875)

on December 28, 2011
at 08:41 PM

+1; http://www.ncbi.nlm.nih.gov/pubmed/11918434

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 08:14 PM

Thanks, very interesting!

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 04:33 PM

Great links, raney!

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 04:29 PM

A more efficient energy supply makes it easier to restore membranes in the brain to their normal states after a depolarizing electrical energy spike occurs, and means that energy is produced with fewer destructive free radicals leftover."

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 04:29 PM

Currently reading the your first link, it's astonishing: "I was taught that glucose was "clean" and ketones were "smokey." That glucose was clearly the preferred fuel for our muscles for exercise and definitely the key fuel for the brain. Except here's the dirty little secret about glucose - when you look at the amount of garbage leftover in the mitochondria, it is actually less efficient to make ATP from glucose than it is to make ATP from ketone bodies!

96bf58d8c6bd492dc5b8ae46203fe247

(37227)

on December 28, 2011
at 04:12 PM

I can't provide citations, but I definitely have an excitable nervous system and I am more calm and alert when fasting.

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3 Answers

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7
0d0842381492a41b2173a04014aae810

(4875)

on December 28, 2011
at 04:19 PM

Evolutionary Psychiatry: Your Brain on Ketones is one of my favorites. I have a five year old nephew that is epileptic; his seizures have been considerably minimized with a moderate fat, no sugar/grains, real food based diet.

Also see:

The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy.

And consider the elevated ghrelin levels that hunger will provide.

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 04:29 PM

Currently reading the your first link, it's astonishing: "I was taught that glucose was "clean" and ketones were "smokey." That glucose was clearly the preferred fuel for our muscles for exercise and definitely the key fuel for the brain. Except here's the dirty little secret about glucose - when you look at the amount of garbage leftover in the mitochondria, it is actually less efficient to make ATP from glucose than it is to make ATP from ketone bodies!

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 04:29 PM

A more efficient energy supply makes it easier to restore membranes in the brain to their normal states after a depolarizing electrical energy spike occurs, and means that energy is produced with fewer destructive free radicals leftover."

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 04:33 PM

Great links, raney!

6
100fd85230060e754fc13394eee6d6f1

(18706)

on December 28, 2011
at 05:08 PM

E2b72f1912f777917d8ee6b7fba43c26

(2384)

on December 28, 2011
at 08:14 PM

Thanks, very interesting!

2
3eca93d2e56dfcd768197dc5a50944f2

(11697)

on December 28, 2011
at 08:22 PM

A Paleo-keto diet is also beneficial for other mental disorders, including bipolar, autism etc. and even Alzheimer's. Basically, if someone has a mental disorder, a Paleo-keto diet seems to help immensely.

0d0842381492a41b2173a04014aae810

(4875)

on December 28, 2011
at 08:41 PM

+1; http://www.ncbi.nlm.nih.gov/pubmed/11918434

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