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Thoughts on IF and leptin levels

Commented on August 12, 2013
Created August 11, 2013 at 2:40 PM

I am currently reading "Fat Chance" by Dr. Robert Lustig and he talks about leptin resistance and its role in obesity. Leptin, produced in fat cells suppresses appetite and speads metabolism and energy expenditure, yet in obese individuals, they have plenty of leptin (due to plenty of large fat cells) but their hypothalamus doesn't recognize it. He then makes the statement that leptin levels drop dramatically after about 12 hours without eating, and for obese, that are leptin resistant anyway, that can exacerbate the problem making them even more hungry, and slowing their metabolism further.

So I personally do a 20-24 hour IF about once every 7-10 days, mainly for metabolic flexibility as I do not have any weight I need to lose. But I have read on here and other places people recommending IF regularly for weightloss. While this might be ok for those last few pounds, is it a good idea for those that have much more than that to lose, as they probably have high leptin levels anyway, and to have daily occurances where their leptin drops might actually slow their metabolism even further.

Edit: This question is about leptin levels in overweight and obese individuals.

C45d7e96acd83d3a6f58193dbc140e86

on August 12, 2013
at 01:06 PM

That is basically the jist of what Dr. Lustig is saying. Due to leptin resistance, obese people are constantly being told they are hungry, even when they are not. Yet for them, to go long periods without eating would lead to a bigger binge, and more leptin resistance.

C45d7e96acd83d3a6f58193dbc140e86

on August 12, 2013
at 01:05 PM

If you maintain an intentional calorie deficit for too long, your hypothalomus is more likely to become resistent to the elevated leptin levels, and will just slow down your metabolism to compensate. Eat to fuel your body.

23fe01308e3320ecf144b47b99a135a4

(149)

on August 12, 2013
at 09:25 AM

English Rose have you considered doing a carb-load?

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2 Answers

0
6fece842bd1bcf5724f458a302a2156e

on August 12, 2013
at 08:16 AM

I have never been able to do due to carb/sugar addiction as it just led to a binge so I would first advise make sure you have changed how you eat and adapted.

However now that I have changed I have been finding some days I can miss a meal (and I have 28 pounds to lose so that's a good thing for me) without feeling too hungry (due to eating more fat).

Certainly research seems to be showing how good it is to give the body a break from food sometimes even though it can be stressful. It seems to let the body heal. It also seems to help conditions like dementia and epilepsy.

What I am concerned about today is that despite a week of very low carb eating, fairly low calories although I do not count them and some IF of 16 hours over night, I have lost no weight at all. I have got to break under the 140 pound mark soon just to encourage myself, yet eating just meat/veg/eggs/fish and the veg all low carb is not losing me a single pound at the moment. I was the same weight a month ago. It is very discouraging although I do feel I am on a long term route to being lighter again so I will just have to keep at it.

C45d7e96acd83d3a6f58193dbc140e86

on August 12, 2013
at 01:05 PM

If you maintain an intentional calorie deficit for too long, your hypothalomus is more likely to become resistent to the elevated leptin levels, and will just slow down your metabolism to compensate. Eat to fuel your body.

23fe01308e3320ecf144b47b99a135a4

(149)

on August 12, 2013
at 09:25 AM

English Rose have you considered doing a carb-load?

0
543a65b3004bf5a51974fbdd60d666bb

(4493)

on August 12, 2013
at 04:40 AM

my basic 'rule' with fasting...if you are able to fast without feeling hungry, it's probably fine to do so (imo). I'm sure there will be exceptions to this very general rule tho (eating disorders?).

But if you cannot fast without getting hungry, probably best not to do it.
& what does it mean if you do get hungry when fasting?...i expect it could be due to all sorts of factors/reasons, & individually based, but leptin could be one of those factors in some, if not all cases...

C45d7e96acd83d3a6f58193dbc140e86

on August 12, 2013
at 01:06 PM

That is basically the jist of what Dr. Lustig is saying. Due to leptin resistance, obese people are constantly being told they are hungry, even when they are not. Yet for them, to go long periods without eating would lead to a bigger binge, and more leptin resistance.

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