There are numerous threads discussing people who went Paleo and had a subsequent increase in their lipoprotein levels. Usually this is in the form of greatly increased LDL-C. This may or may not be a problem according to the latest "flavor of the week/year" in lipoprotein research, which posits that it's the number of LDL particles (LDL-P) that drives athersclerosis.
Some say that insufficient iodine/selenium, too great an intake of goitrogens, too little carbohydrate intake, or some combination of these is causing hypothyroidism which can indeed drive up LDL-C and LDL-P due to decreased LDL receptor expression hence decreased clearance. Others blame FH (familial hypercholesterolemia) which begs the question: why did it only manifest after switching to a Paleo diet? Others have found eliminating certain foods (dairy fat) to help lower cholesterol levels.
One confounding factor is that meal frequency often decreases on a Paleo diet due to greater satiety and also the general consensus in the paleo-sphere that snacking is bad for your metabolism (see J. Stanton's treatise here: http://www.gnolls.org/1794/why-snacking-makes-you-weak-not-just-fat/).
I found some recent research that gives evidence that eating more frequently versus less decreases many lipoprotein levels, including ApoB, which is a good appoximation for LDL-P: http://www.sciencedirect.com/science/article/pii/0026049595900667 http://www.ncbi.nlm.nih.gov/pubmed/12973474
Can anyone else corroborate these findings? I may try a self-experiment with more frequent meals if I can get my doctor to agree to more freqeunt ApoB testing.
Bonus question: Does LDL-P really matter? See this post where the doctor's LDL-P went through the roof (over 3000), but his carotid intima media thickness (CIMT) dropped over the same time period: http://azsunfm.blogspot.com/2012_09_01_archive.html
UPDATE: I had a basic cholesterol test done last month and my LDL-C has gone down by 40 points (220->180) over the last 6 months. I still more or less do 16/8 IF, but I frequently eat 3 meals in that window instead of 2. I also upped my carbs a good bit (paired with a lowered intake of fat), even on rest days. Also, I started eating a Brazil nut each day (for selenium) and getting some seaweed each week (for iodine). In other words, I have no idea which change in my lifestyle and diet caused the LDL to lower, but something did.
asked byRyan_36 (1042)
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