7

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does excess body fat prevent increased autophagy during IF?

Answered on August 19, 2014
Created November 29, 2011 at 2:52 PM

i came across this blog

in the comments section for the linked article the blogger wrote

Autophagy is an ongoing process that declines with age, it doesn???t really turn on or off. But you can ???increase??? function, which can help people more as they age (not really with younger people who are already running at peak capacity). There has to be a ???low food??? stress to signal an increase so it starts ???consuming itself??? at the cell level for energy (and in some cases exercise may do this as well). I???ve read that this is also dependent on one???s bodyfat, because as you fast your body turns to fat for energy. So if you have more fat stored, you are still not signaling enough of a ???low food??? environment compared to someone who is lower in bodyfat

is it possible that IF only increases autophagy in people with low bodyfat?

64433a05384cd9717c1aa6bf7e98b661

(15236)

on November 29, 2011
at 03:28 PM

Ah that's what raydawg also said

B4e1fa6a8cf43d2b69d97a99dfca262c

(10255)

on November 29, 2011
at 03:10 PM

so the flaw in his logic is that autophagy is not primarily a means of sourcing energy?

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2 Answers

1
96440612cf0fcf366bf5ad8f776fca84

(19473)

on November 29, 2011
at 03:02 PM

Far as I understand, (and I'm a sysadmin/programmer, not a bio-med guy) is that autophagy removes the excess junk proteins within the cells as well as dead cells and forces apoptosis in marginal cells.

The removal of triglycerides from fat cells for fuel is separate from autophagy, though that will lean you out.

So it's concerned with proteins, not fats. It should work just as well whether you're fat or lean.

B4e1fa6a8cf43d2b69d97a99dfca262c

(10255)

on November 29, 2011
at 03:10 PM

so the flaw in his logic is that autophagy is not primarily a means of sourcing energy?

0
64433a05384cd9717c1aa6bf7e98b661

(15236)

on November 29, 2011
at 03:23 PM

I believe it's not a 'low fuel' signal in the sense that it needs ATP, but rather it's a low 'building blocks' (amino acids) signal so it needs to scavenge around for what it can use.

This is why people may do things like not eat protein after 2pm, or stay very low protein on weekends, etc.

64433a05384cd9717c1aa6bf7e98b661

(15236)

on November 29, 2011
at 03:28 PM

Ah that's what raydawg also said

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