1

votes

What is optimal Serum LEPTIN?

Answered on August 19, 2014
Created June 27, 2012 at 11:42 PM

Just got some fasting labs back. My fasting bg and insulin were way too high a month ago so we retested to make sure I don't have "pre-diabetic" condition, and/or Insulin Resistance, and/or Leptin resistance

There's improvement in glucose and insulin from a month ago when it was last tested - the difference is that I am no longer vcl rather more "low carb" (less than 100 grams) These are fasting levels:

GLUCOSE 91 (was 98 a month ago)

INSULIN 5.9 (was 9.0 month ago)

LEPTIN 8.3 (is this optimal or just OK or what?)

A1C 5.4

REVERSE T3 30.9

My other thyroid values are optimal. Vit D level is 77

Of interest to me is that I cannot lose one pound on the low calorie (1300 average), low carb, high protein and high healthy fat diet I have been on. Its really pissing me off as I know for a fact that if I was doing say Weight Watchers (low fat, high carb) and eating unlimited fruit all day I would lose the extra 6-9 pounds of FAT that I need to lose.
No I do not having an eating disorder Yes I am being realistic.

Anyway would love any input, opinions, impressions or facts related to the above and particularly related to the metabolic stuff.
I do not know what is ideal for Leptin.

Thanks a million

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:50 AM

TAhnks Patrick. I know all about Net carbs... thanks

2353504a9c35c6049c3722cd337737cb

(108)

on June 28, 2012
at 02:18 AM

It sounds like you're doing well, just maybe not acheiving your body comp goals. As for healthy carbs, I just substract fiber grams from total carbs. That difference is what turns to sugar in the blood and raises glucose, leptin, and insulin...so the only healthy carbs for me are high fiber leafy greens, broccoli, cauliflower, avocado, and the like. I'm definitely not in the safe starch camp, but I do love my sushi now and then lol.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:07 AM

and the high fat (butter olive coconut and some nuts) has not in fact worked for me and this has been of GREAT disappointment... It getting a FIT assessment by Pathways Genomics per my nutritionist. Some people genetically, it turns out, dont' do well on "high" fat. Of course I have never gone 80% fat. I could stay low carb (not doing vlc anymore) but eat more fat than protein & see if that helps. Too much protein might not be work for me. Although I have felt great but cannot lose weight compared to how it has always been and its not hormones or anything. Im chemcially enhanced (bio-hrt) lol

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:02 AM

Patrick in summary for low carb diets, that is not too high of a fasting Bg. The HBA1c is a more valuable number and mine is OK but barely... which is odd to me given what I eat (rather don't eat).

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:01 AM

Thanks! I should add that this is the first time EVER in 20 yrs of yearly labs that my Fbg has been over 85! This corresponds with Primal type of diet for past year!! The changes in the last month are since adding back more (healthy) carbs. I now know from Chris Kresser and others that many low carb folks (I was very low carb at 50 and now am lc at 100) have a higher fasting bg level so that is not the concern. I have monitored post meal and I am averaging 100 at peak. My A1C is OK but barely and that is weird, given the lc/vlc and VERY LOW sugar. I think there are individual differences

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 01:57 AM

Thank you Patrick!

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 01:49 AM

Got it. Thanks

B4e1fa6a8cf43d2b69d97a99dfca262c

(10255)

on June 28, 2012
at 01:36 AM

that seems reasonable- sorry my initial answer had a typo; please review.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 01:27 AM

Thanks Sage. This was 12.45 pm. T

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3 Answers

1
2353504a9c35c6049c3722cd337737cb

on June 28, 2012
at 01:55 AM

First of all, congratulations on significantly lowering your fasting glucose and insulin levels. It seems that you're making a lot of good dietary choices in order to see those improvements. Dr. Rosedale (drrosedale.com), who I respect a great deal sugests that optimal range for leptin is 4-6 ng/dL, glucose 70-85, HbgA1C <5.4, and insulin <10 IU/mL. If your insulin remains low you shouldn't accumulate fat, but your glucose is still high, which could suggest that you're eating too much carb and/or protein. Excess protein beyond what the body needs will be converted to glucose in the liver via gluconeogenesis. If you've been insulin and leptin resistent for years (chronically high hormone levels leading to cells inability to receive their signals) it will take several weeks to convert from sugar burning to fat burning. I find that if I drop out of keytosis for long (>50g carbs/day) I gain fat quickly. Over the past year I've lost 40lbs of fat (196 down to 156 lbs now) and I see how my 40 years of poor diet have damaged my metabolism. I find that I have to stay VLC (<30g/day), with moderate protein (no more than 20g/meal, 60g/day), and getting most of my calories from healthy fats (70-80%) to stay lean. Everyone's metabolism is in a different state of health, but if you eat 80% calories from fat you will get very lean (or at for sure the leanest you can possibly be).

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 01:57 AM

Thank you Patrick!

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:50 AM

TAhnks Patrick. I know all about Net carbs... thanks

2353504a9c35c6049c3722cd337737cb

(108)

on June 28, 2012
at 02:18 AM

It sounds like you're doing well, just maybe not acheiving your body comp goals. As for healthy carbs, I just substract fiber grams from total carbs. That difference is what turns to sugar in the blood and raises glucose, leptin, and insulin...so the only healthy carbs for me are high fiber leafy greens, broccoli, cauliflower, avocado, and the like. I'm definitely not in the safe starch camp, but I do love my sushi now and then lol.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:07 AM

and the high fat (butter olive coconut and some nuts) has not in fact worked for me and this has been of GREAT disappointment... It getting a FIT assessment by Pathways Genomics per my nutritionist. Some people genetically, it turns out, dont' do well on "high" fat. Of course I have never gone 80% fat. I could stay low carb (not doing vlc anymore) but eat more fat than protein & see if that helps. Too much protein might not be work for me. Although I have felt great but cannot lose weight compared to how it has always been and its not hormones or anything. Im chemcially enhanced (bio-hrt) lol

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:02 AM

Patrick in summary for low carb diets, that is not too high of a fasting Bg. The HBA1c is a more valuable number and mine is OK but barely... which is odd to me given what I eat (rather don't eat).

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 02:01 AM

Thanks! I should add that this is the first time EVER in 20 yrs of yearly labs that my Fbg has been over 85! This corresponds with Primal type of diet for past year!! The changes in the last month are since adding back more (healthy) carbs. I now know from Chris Kresser and others that many low carb folks (I was very low carb at 50 and now am lc at 100) have a higher fasting bg level so that is not the concern. I have monitored post meal and I am averaging 100 at peak. My A1C is OK but barely and that is weird, given the lc/vlc and VERY LOW sugar. I think there are individual differences

1
B4e1fa6a8cf43d2b69d97a99dfca262c

(10255)

on June 28, 2012
at 01:23 AM

leptin concentration starts low in the morning and rises throught the day to peaks at about 2am with a typical range of 4-16 ng/ml. i think the pattern is the important aspect. your level is within this range, but what it means is dependent on the time of day it was sampled i would guess.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 01:49 AM

Got it. Thanks

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 28, 2012
at 01:27 AM

Thanks Sage. This was 12.45 pm. T

B4e1fa6a8cf43d2b69d97a99dfca262c

(10255)

on June 28, 2012
at 01:36 AM

that seems reasonable- sorry my initial answer had a typo; please review.

0
4ef079c57d2140bba4dbf4e30240a645

on June 28, 2012
at 04:33 PM

I finally found something about this online!

tuesdayminute.net/Leptin%20protocol.doc

Leptin of 4-6 ng/dl is Optimal

up to 9 ng/dl is Acceptable 

        10+ is too High.  

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