Alpha Lipoic Acid, Biotin, Insulin Resistant and Hypoglycemia

Answered on August 19, 2014
Created May 16, 2013 at 9:16 PM

Hello -

I am insulin resistant, ketogenic paleo, 35 year old woman. I have 15-30 pounds to lose. I lost the first 10 after going keto but now it won't budge. Doesn't matter what I do - lower carbs, higher, more exercise, couch potato, weights - nothing. Ugh!

Doctor says I'm insulin resistant after being hypoglycemic most my life. He put me on glucophage but I got weird pins and needles in my arm, so I stopped.

I'm trying 600 mg of ALA because it's supposed to be the good for insulin resistance. I read that it will deplete Biotin so I'm taking 6 mg of biotin a day too.

I got pins and needles but the biotin makes it go away. It also makes me feel great. Chronic muscle and back aches are completely gone.

I'm also taking L-Carnitine & CoQ10.

I guess my question is this...

-Anyone have a bad experience with these vitamins? The dosages are high, so I'm concerned.

I would go back to the doctor but I don't trust him since he said I should ignore the pins and needles I got with Glucophage.

I would appreciate any feedback. I half-wonder if I should drop the others and just take biotin. I've been reading how it fixes Hypoglycemia and since that's what I started with, I just wonder if it will fix it.



on May 23, 2013
at 01:43 AM

Try adding in Thiamine in the form of Benfotiamine, supposed to help with diabetic neuropathy.

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2 Answers



on June 05, 2013
at 08:23 PM

The insulin resistance is very likely due to being ketogenic. When you are on a ketogenic diet, the liver still puts glucose out into the blood for the brain. Now, this glucose would not get to the brain were it not for insulin resistance. This kind of insulin resistance is okay and actually healthy in the context of a ketogenic diet.

So, they get us into the doctor's office, where we are nervous in the first place, and then hit us with a whack of 75g glucose.

What they should do is have us gradually reintroduce carbs over a few weeks, and then test.

You are probably okay with your current supplements. It would certainly be cheaper if you find out the biotin is what is making you feel better. I am a little worried about the ALA in your case because if you are actually hypoglycemic, well ALA tends to lower blood sugar. So it could put you too low, and could contribute to you passing out for no apparent reason.

Anyway, I'd suggest being patient. Your happy reaction to biotin suggests a nutritive deficiency, which means you need to focus on getting enough nutrition, not on weight loss. Now, I can't make any gaurantees, but I have heard tales of people getting their nutrition right, only to find out they do end up losing the weight. The body isn't too happy about giving up a resource (those pounds of fat) when it isn't seeing what it needs coming in via diet. So relax, and focus on eating nutritious things, and not on calories, carbs, etc... As long as you follow the paleo framework, you ought to get there eventually.


on May 22, 2013
at 04:33 PM

I would stick with the ALA, ALC, CoQ 10 and Biotin. They are good for alot of things including insulin resistance. You might be able to get by with 200 mg of a solubilized ALA (thiogel), or 400 mg at most.

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