Hi. I have recently seen my leptin resistance go away as my appetite has normalised (first time in my life). I'm really enjoying being free from the constant hunger and worry about food. What I wanted to know is if anyone knows how closely leptin and insulin resistance are linked. If my leptin resistance is going, does that mean my insulin resistance is also going?
asked byRiver_Song (10)
Get FREE instant access to our Paleo For Beginners Guide & 15 FREE Recipes!
on August 15, 2013
at 11:25 AM
As far as I know (no doc here, just an educated layperson, based on Dr Kruse ideas and some others), it seems that leptin resistance precedes insulin resistance. Leptin receptors at the hypothalamuns account for the body status of energy. If this sensors do not work well, bad signaling occurs that might lead to fat storage with time, fat also develops more leptin hormone, so more leptin secretion from fat, that signals leptin stronger, that leads to the leptin receptors to become less and less sensitive over time... so more chaos detecting how much energy your body has.
Then your patterns for food seeking behave in the wrong way, you might start to need to eat more and more food and most probably the worst stuff, that coupled with gut damage from the bad dietary choices and high GI carbs that raise blood sugar constantly so insulin is released in huge quantities on a constant fashion that leads to more fat storage and eventually to metabolic syndrome as the gut and the liver build up more and more damage. All this paired with omega 6 PUFA's, gut permeability that allow for proteins to leak and cause immune reactions, so more body circulating levels of cytokines that trigger a lot of inflammation that makes things worse over the time, leading to more chaos at the hypothalamus, liver and gut and other organs sensitive to the inflammation... this inflammation might also raise cortisol a lot which breaks down the normal thyroid and hormonal cascade via the pregnenolone stealth syndrome.. really all the organs and endocrine, digestive system and the brain are pretty much tied toghether in the obesity disease.
It seems that as you regain the leptin sensitivity by trying to revert the previous chaos, insulin sensitivity also raises, the most important mechanisms are stabilizing blood glucose, dieting, so you start getting rid of fat, especially visceral fat, that has a lot of that inflammatory cytokines that lead to general body inflammation that block leptin receptors, if you revert your weight to normal and lower your inflammation and you support the liver, it seems that the brain can start to count back on energy status better and thus T3 production and sex hormones can improve and start seeing overall improvement in all aspects.
But, if you have been so messed up that you destroyed almost all your beta-cells that secrete insulin.. then you might not be able to revert the situation, but it's most likely that you are not so far yet, so I'd say, yep, you can.
I know that the explanation is very messy, that's a general picture wrote down fast, hopefully someone might give you a more well formulated answer :)