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Study Suggests Anti-inflammatory Aspirin is Better Cancer Fighter than Other NSAIDs?

Answered on August 19, 2014
Created March 11, 2013 at 2:16 PM

Just saw this study on NPR not a PDF

I think everyone here gets the inflammation-cancer connection, but why would aspirin work better than ibuprofen?

337b24e948ed467fa775b5f56f51560c

on March 11, 2013
at 04:04 PM

Ah. That makes some sense. What do you think is the relative effect of aspirin compared to paleo diet? I was interested in this article because I was thinking "reduced inflammation is related to reduction in cancer, duh." But I've never heard anything linking blood thinning or anti-clotting to paleo lifestyles, so I wonder what's up with that?

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2 Answers

2
Ebb10603524dd22621c1155dd7ddf106

(19150)

on March 11, 2013
at 02:37 PM

Aspirin is the only NSAID that inhibits clotting. IIRC, low dose aspirin is often prescribed by doctors not for NSAID reasons, but for blood-thinning and anti-clotting reasons.

I have no idea what the mechanism against cancer might be, but aspirin is unique in this regard.

337b24e948ed467fa775b5f56f51560c

on March 11, 2013
at 04:04 PM

Ah. That makes some sense. What do you think is the relative effect of aspirin compared to paleo diet? I was interested in this article because I was thinking "reduced inflammation is related to reduction in cancer, duh." But I've never heard anything linking blood thinning or anti-clotting to paleo lifestyles, so I wonder what's up with that?

0
A2c38be4c54c91a15071f82f14cac0b3

(12682)

on March 11, 2013
at 11:22 PM

It's my understanding that aspirin uniquely promotes the synthesis of substances called lipoxins. These lipoxins appear to have some anti-inflammatory and anti-angiogenic properties. Check out the paper "Novel Lipid Mediator Regulators of Endothelial Cell Proliferation and Migration: Aspirin-Triggered-15R-Lipoxin A4 and Lipoxin A4" for info.

Since angiogenesis is the process by which tumors acquire blood vessels to gain a better supply of nutrients, these lipoxins may at least partially explain why aspirin appears to be a more cancer preventative NSAID.

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