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Inflammation and blood ketone

Answered on August 19, 2014
Created August 13, 2013 at 6:51 PM

So I have read somewhere that inflammation could cause a spike in blood sugar.

I suspect I have some yet to be identified food allergies, and it made me wonder if anytime inflammation is triggered in my body, if that wouldn't raise my blood sugar, and by doing so, lower my blood ketone level (my understanding is, the more blood sugar there is, the lower the ketone production)

Or, since my glycogen store is already depleted from the ketogenic diet, is it the ketone level that raises instead of sugar during an inflammatory response? Or would it raise both BG and BK level?

Which seems logical to you guys? any insight is appreciated.

0f44d81f247518d6fc2de0403ff9a68a

on August 28, 2013
at 05:26 AM

Glycogen stores don't get depleted on a ketogenic diet. Because your body doesn't use a lot of glucose on a ketogenic diet, the small amount of carbs + the glucose created from gluconeogenesis are enough to keep sufficient glycogen stores.

Ffb647bad862697f84b08c513807ac16

(10)

on August 14, 2013
at 09:20 PM

Yes I think my body does need more carb/protein when I'm inflamed, because I have cravings after eating cheese, which I suspect I'm allergic to. Of course, I'd be better off avoiding the allergens in the first place. I'm not trying to create controversy, but IMO we can get away with way lower amount of dietary protein than most people here are led to believe, because nutritional ketosis triggers autophagy. Some days I eat close to no protein at all, and I haven't noticed any muscle-loss. Well that's what I observe with my bare eyes, so I can't tell for sure. Thx for the input anyways :)

82166cc32b6cf26de33b69f58fb583b1

on August 14, 2013
at 06:38 PM

Loss of muscle mass is always a risk on a severely ketogenic diet because in order to reach high ketosis, protein has to be restricted. This is true with or without inflammation. Therefore, with or without inflammation, you have to monitor the amount of lean mass in your body to make sure you're not losing more than you're willing to lose. You have to do this regardless of whether there's inflammation or not. If the rat studies apply to humans, you would probably need more protein while inflamed, but this wouldn't change the need to monitor and adjust the diet.

Ffb647bad862697f84b08c513807ac16

(10)

on August 14, 2013
at 02:44 PM

So I could possibly lose muscle mass simply from inflammation if I don't remove the allergens from my diet, unless there is enough dietary carb and protein intake... That's very interesting. Thanks a lot :)

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1 Answers

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82166cc32b6cf26de33b69f58fb583b1

on August 14, 2013
at 11:50 AM

Inflammation lowers ketone levels in rats. I don't know of any studies in humans.

Low stores of glycogen don't stop the body from raising blood glucose because the liver can produce large amounts of glucose. If necessary the body cannibalizes muscle tissue to obtain raw material for this purpose.

See for example Neufeld, H. A., M. V. Kaminski, and R. W. Wannemacher. "Effect of inflammatory and noninflammatory stress on ketone bodies and free fatty acids in rats." The American journal of clinical nutrition 30.8 (1977): 1357-1358.

82166cc32b6cf26de33b69f58fb583b1

on August 14, 2013
at 06:38 PM

Loss of muscle mass is always a risk on a severely ketogenic diet because in order to reach high ketosis, protein has to be restricted. This is true with or without inflammation. Therefore, with or without inflammation, you have to monitor the amount of lean mass in your body to make sure you're not losing more than you're willing to lose. You have to do this regardless of whether there's inflammation or not. If the rat studies apply to humans, you would probably need more protein while inflamed, but this wouldn't change the need to monitor and adjust the diet.

Ffb647bad862697f84b08c513807ac16

(10)

on August 14, 2013
at 02:44 PM

So I could possibly lose muscle mass simply from inflammation if I don't remove the allergens from my diet, unless there is enough dietary carb and protein intake... That's very interesting. Thanks a lot :)

Ffb647bad862697f84b08c513807ac16

(10)

on August 14, 2013
at 09:20 PM

Yes I think my body does need more carb/protein when I'm inflamed, because I have cravings after eating cheese, which I suspect I'm allergic to. Of course, I'd be better off avoiding the allergens in the first place. I'm not trying to create controversy, but IMO we can get away with way lower amount of dietary protein than most people here are led to believe, because nutritional ketosis triggers autophagy. Some days I eat close to no protein at all, and I haven't noticed any muscle-loss. Well that's what I observe with my bare eyes, so I can't tell for sure. Thx for the input anyways :)

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