2

votes

GLA: A Good Omega 6?

Answered on August 19, 2014
Created January 17, 2011 at 12:14 PM

GLA, the LONG CHAIN Omega 6 in Evening Primrose/Borage Oil might be good?

this is the Omega6 equivalent to DHA/EPA (long chain Omega 3s)

and just like short chain Omega 3, ALA, isnt so great, we know short chain Omega 6 like LA is bad...

but is the long chain, post conversion GLA still bad? is it in fact the opposite of the short chain and anti-inflammatory?

Lipoxins and resolvins in inflammatory bowel disease. Weylandt KH, Kang JX, Wiedenmann B, Baumgart DC.

Department of Medicine, Division of Hepatology and Gastroenterology, Charit?? Medical School-Virchow Hospital, Humboldt-University of Berlin, Germany. Abstract Lipid mediators are important messengers in many physiological processes. The pro-inflammatory effect of many prostaglandins, derived from the essential arachidonic acid, are well established. However, there are also anti-inflammatory lipid mediators: lipoxins and resolvins, derived from essential omega-6 and omega-3 polyunsaturated fatty acids (n-3 and n-6 PUFA), have been shown to control and resolve inflammation in a variety of experimental models of inflammatory disorders. Recent research implicates n-6 PUFA-derived lipoxins and their stable analogues as potent anti-inflammatory compounds in models of inflammatory bowel disease. Similarly, n-3 PUFA-derived lipid mediators such as resolvin E1 were shown to protect from experimental colitis in animal models. Some of their anti-inflammatory effects are mediated by dendritic cells. In this article we discuss the emerging knowledge on the effects of lipoxins and resolvins on various inflammatory pathways and why they are promising candidates for novel therapies of human inflammatory bowel disease.

??? Daily supplementation with Evening Primrose oil reduces symptoms of atopic dermatitis. (Andreassi et al; J Int Med Res, 1997 & Senapati et al; Indian J Dermatol Venereol Leprol, 2009 & Hederos et al; Arch Dis Child, 1996)

??? 1.5 g/d of GLA significantly reduced leukotriene production after just one week (thereby reducing inflammation). (Surette et al; Clin Therapeutics, 2003)

??? 1.8g/d of GLA has been shown to improve arthritis pain by reducing the number of tender and swollen joints. (Leventhal et al; Ann Intern Med)

??? GLA has been shown to reduce tumor growth. (Serini et al; Apoptosis, 2009)

Lets hear some opinions :)

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 05, 2011
at 02:38 PM

ALA is actually widely used to reverse polyneuropathy deriving from diabetes. It shows some positive effect but only at a very high dose, again. 600mg is recommended for diabetics with neuropathy but a much higher dose will be required to see any improvement. Biotin is not a mimetic but something you need to take becuz ALA and biotin compete for the same enzymes, just like n-3 and n-6.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 05, 2011
at 02:36 PM

In the most recent teleconference, Dr. B said ALA doesn't show any noticeable improvement. Some of his patients report improvements but many don't. This one is more like Chromium, which may show improvement if you take a high enough dose (but could be toxic for your kidneys) but has minimal effect on BG at a regular (i.e., safe) dose.

1ac8e976f84cb2566ecfbbcce1817351

(211)

on March 14, 2011
at 03:51 AM

I can't seem to find a GLA supplement that is not heavily fused with LA. Any help anyone?

A968087cc1dd66d480749c02e4619ef4

(20436)

on March 05, 2011
at 09:52 AM

Yes, Alpha Lipoic Acid is an insulin mimetic according to Dr. Bernstein. http://www.diabetes-book.com/book/chapter15.shtml

Cf5c9ba3c06cf300ae23c52778dfd317

(545)

on February 14, 2011
at 11:44 PM

ALA as an insulin mimetic? Would that be Alpha Lipoic Acid he is referring to? It's often used in blood sugar control supplements.

4b97e3bb2ee4a9588783f5d56d687da1

(22923)

on January 17, 2011
at 01:10 PM

err smothering a fire with lighter fluid...

4b97e3bb2ee4a9588783f5d56d687da1

(22923)

on January 17, 2011
at 01:09 PM

ALA is a short chain, not fond of it. Id check your EPO and make sure that its Just GLA and not a blend, alot of the standards are 90% LA and 10% GLA, which seems like dipping your vitamins in cyanide.

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3 Answers

2
B14dc4aa1ddefbec3bc09550428ee493

on July 05, 2011
at 12:36 PM

Several years ago I was having terrible mood swings around the time of my period. One minute I'd be snapping your head off and the next I'd burst into tears. Evening primrose oil cured me within the space of a few weeks. So, if you need it, it can be very, very good for you. I think like anything else it's about being in the right balance. Going by the popularity of using antidepressants for PMS, I'd say that many women could benefit from supplementing with evening primrose oil.

0
6e01c5e248d6a30bb7cb07d536aaf5b6

(193)

on May 10, 2011
at 04:50 AM

the Nutrex Hawaii Hawaiian Spirulina is a decent source of GLA, no LA as far as I know, also a good source of natural Beta-Carotene and Zeaxanthin. Since it is a whole food supplement it is probally better than taking borage or evening primrose oil.

0
A968087cc1dd66d480749c02e4619ef4

(20436)

on January 17, 2011
at 12:50 PM

Dr. Bernstein recommends EPO with ALA and Biotin as an insulin mimetic for T2 diabetics. I am on it now, but I don't see a huge improvement over just watching my food and IF and exercise...

I asked the question in another thread about whether I should worry about the n6 in the EPO. Never got any real clarification on that, so this is interesting.

4b97e3bb2ee4a9588783f5d56d687da1

(22923)

on January 17, 2011
at 01:09 PM

ALA is a short chain, not fond of it. Id check your EPO and make sure that its Just GLA and not a blend, alot of the standards are 90% LA and 10% GLA, which seems like dipping your vitamins in cyanide.

4b97e3bb2ee4a9588783f5d56d687da1

(22923)

on January 17, 2011
at 01:10 PM

err smothering a fire with lighter fluid...

Cf5c9ba3c06cf300ae23c52778dfd317

(545)

on February 14, 2011
at 11:44 PM

ALA as an insulin mimetic? Would that be Alpha Lipoic Acid he is referring to? It's often used in blood sugar control supplements.

A968087cc1dd66d480749c02e4619ef4

(20436)

on March 05, 2011
at 09:52 AM

Yes, Alpha Lipoic Acid is an insulin mimetic according to Dr. Bernstein. http://www.diabetes-book.com/book/chapter15.shtml

1ac8e976f84cb2566ecfbbcce1817351

(211)

on March 14, 2011
at 03:51 AM

I can't seem to find a GLA supplement that is not heavily fused with LA. Any help anyone?

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 05, 2011
at 02:38 PM

ALA is actually widely used to reverse polyneuropathy deriving from diabetes. It shows some positive effect but only at a very high dose, again. 600mg is recommended for diabetics with neuropathy but a much higher dose will be required to see any improvement. Biotin is not a mimetic but something you need to take becuz ALA and biotin compete for the same enzymes, just like n-3 and n-6.

3c6b4eed18dc57f746755b698426e7c8

(5147)

on July 05, 2011
at 02:36 PM

In the most recent teleconference, Dr. B said ALA doesn't show any noticeable improvement. Some of his patients report improvements but many don't. This one is more like Chromium, which may show improvement if you take a high enough dose (but could be toxic for your kidneys) but has minimal effect on BG at a regular (i.e., safe) dose.

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