2

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Are IgG food sensitivity test results useful in the context of reducing leaky gut inflammation?

Commented on November 17, 2014
Created June 01, 2012 at 11:35 PM

The accuracy of IgG allergy tests have been shown to be limited at best, but are there contexts in which the data can be useful? I'm particularly interested in its application as a temporary means to reduce the inflammation of leaky gut, so the stomach can begin the healing process.

Chris Kresser mentioned on a recent podcast that a??colleague drew two blood samples from himself at once, sent them to the lab under two names and got back wildly different results.????Not encouraging. ??Eva also made a good point in a previous PH leaky gut question.

...your body will react negatively to any food that escapes into the body without being properly digested first. ??The more you eat a food, the more likely??particles of that food could have snuck through a leaky gut undigested. ??So the more likely your body has had to make antibodies against that food. ??If??you never ate a food, it would be impossible for you to have antibodies against that food. ??If you rarely eat a food, you would most likely have few??antibodies against that food. ??Your results are actually totally expected. You would expect that your body would have more antibodies against food you??eat more of.

Yup. ??With a few exceptions, the foods the test says I'm sensitive to are foods I eat frequently. ??Beef. ??Chicken. ??Salmon. ??Coconut. ??Eggs. ??Ginger. ??Black pepper. ??Avocado. ??Squash. ??Spinach. ??Lemons. ??Limes. ??Broccoli. ??Lettuce. ??(lettuce? seriously?) The list goes on. So wouldn't it stand to reason that if I limit myself to the few foods the test allows, I'll just start making antibodies to those foods instead?

My understanding of leaky gut/adrenal fatigue/autoimmune disease, is that they're circular reactions driven by chronic inflammation. ??Chronic high cortisol can cause a permeable gut to begin with. ??In my case, we suspect a combination of excessive mercury amalgams (which have since been removed) and a series of about 6 rounds of antibiotics I received in less than a month back in 2008??when I was hospitalized for a badly infected stingray wound. ??Leaky gut causes inflammation, which raises cortisol, which creates more inflammation, which further damages the gut... around and around it goes.

As for the IgG test results, my initial reaction was "what can it hurt - just try it" but since my IgG test showed a reaction to virtually EVERY food I eat, I'm wondering if I'm wasting my time (and money) on tests like this. Is it worth the extreme deprivation?


Some background info:

I have been seeing an endocrinologist for hashimoto's. ??After about 18 months of unimproved health issues, including but not limited to??debilitating chronic fatigue, unexplained weight gain, increasingly foggy memory and skin issues that no amount of thyroid hormone seems to help. ??I am now (also) seeing a functional??medicine doctor who has diagnosed me with??leaky gut and??stage-2 adrenal fatigue. ??I guess it's not terribly surprising since, where there's one autoimmune disease, there are usually more. ??I chose my current functional medicine doctor because he is a student of??Dr. Kharrazian, whose approach to hashimoto's/autoimmune disorders makes more sense to me than anything else I've seen.

I've had a ton of testing done, including:

salivary adrenal stress test (depressed)
cortisol load (19nM)
DHEA (non-adapted, low reserves)
total salivary SIgA (<5 depressed)
stool cu. fungi, isol, & I.D. (light candida)
estrone (depressed)
estradiol (4 pg/ml)
ova & parasites (none)
bacterial stool cu. (moderate gamma hemolytic streptococcus)
helicobacter pylori Ab, IgG (negative)
progesterone (depressed)
free testosterone (normal)
vitamin D (54.0 ng/mL)
Hgb A1c (5.1%)
estimated avg. glucose (99.7 mg/dL)
CBC (normal)
total cholesterol (172.0)
triglycerides (44.0)
direct HDL (70.0)
calculated LDL (93.2)
chol/HDL ratio (2.5)
ferritin (39.0 ng/mL)

Most recently, they ran an IgG Allergens test that showed antibodies to just about every one of the 96 test foods. ??I fully expected to see some positive results, since it's clear I've been reacting to something, but I was shocked to see so many positives. ??I regularly break out in red splotches on my chest and flush so much I look sunburned, but I've never been able to pinpoint a certain food that might be causing it. ??I suspected gluten in the beginning, but religiously avoiding all possible sources of gluten have not improved the weird flushing phenomena.

I've been working with this doctor to heal my leaky gut issues for about six months. ??I've done elimination diets, I've done gut repair protocols. ??Originally, I was started on??Clearvite,??Repairvite??and??GI Synergy, which are part of Dr. Kharrazian's recommended program, but apparently my gut was so messed up that they just made me sick to my stomach. ??We stopped those and I switched to??NeuroScience GI Reset??and??GI Barrier Repair, which I completed prior to the IgG blood test. ??In addition to probiotics, vitamin D, B complex, C, magnesium, adrenal glandular, selenium and zinc, I'm also on a high dose??DHA/EPA blend?? ??The serving size is 1 T, but they have me taking 2-3 T daily. ??I've seen mixed reviews about high-dosing fish oil, so I'm not sure what to think of that. ??We're also trying??topical glutathione cream, aloe juice and colostrum supplements.

Now I've been told to completely eliminate every food that came back "abnormal" on the test, and was given a couple of anti-inflammatory supplements (this??and??this). ??In a few weeks, once my immune system has had a chance to calm down, we're going to begin a new leaky gut repair??protocol, designed for severe cases of intestinal permeability. ??Not clear what that will involve yet. ??Probably more herbs. ??The doctor says that??once we "fix" my leaky gut issues, I should be able to eat most of these foods again someday. ??He said there's a new blood test that can actually confirm??whether the gut lining is still permeable, and we'll run that when we're done with the healing protocol. ??After six months or so, he also wants to rerun this IgG??test to confirm that I'm no longer producing antibodies to these foods.

I'm not afraid of tightening up my diet. ??If this is what needs to be done to get better, then I'm thrilled to do it.????I can survive on turkey, pork and potatoes for awhile. ??I'm just becoming a??little... jaded. ??I get excited about uncovering a new piece of the "puzzle" and optimistically start a new set of supplements or dietary restrictions or whatever. ??I diligently following every instruction, but I'm not seeing any improvement. ??And it's getting expensive. ??I was almost excited to see those allergy test results... finally, something concrete that I can act on! ??But after a little Internet research on the usefulness of IgG tests, now I'm doubting again.

7b9b5de13a30c823dae64a971cb14add

(540)

on March 30, 2014
at 06:28 PM

yes please!

0242b468fe1c97997749db416c92e7ed

(4528)

on August 04, 2012
at 04:31 PM

I should also say that I haven't had the splotchy chest flushes and tingly, numb face/cheeks phenomena once since beginning the elimination diet. I suspect that eggs, coconut and avocado were some of the worst offenders for me - they were also foods I ate with the highest frequency. The real test for me will be if I can successfully reintroduce them at the end of this elimination.

0242b468fe1c97997749db416c92e7ed

(4528)

on August 04, 2012
at 04:26 PM

I'm not sure... They also switched my thyroid medication to Armour, which seems to be helping a lot... There are too many variables to say for certain. I just had another 24-hour saliva test done, so we'll be able to compare how my hormones and adrenals are doing. I feel a LOT better than I did energy-wise, but I'm still anxious to lose the 30 pounds I gained when I first got sick, and that's still not happening. Baby steps, I guess! :)

7841848bd0c27c64353c583fb7971242

(7275)

on August 04, 2012
at 04:09 AM

Kimmie, did the food elimination seem to make a difference?

91882203467f64f68f25f58f1caeee68

(1017)

on June 18, 2012
at 02:21 AM

Have any of you tried PermaVite with any success?

4886d3390cb1de913ecc198e72cc072c

on June 05, 2012
at 04:08 AM

Thanks Crowlover for posting this info! I ordered PermaVite and anxious to try it.

2d090e680d86e2c768edb40b4b433978

(384)

on June 04, 2012
at 07:19 PM

I feel like I could have posted this. I have seen some improvement so long as i follow protocol, but I've had a few deviations, and man, do I pay for them!

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 04, 2012
at 05:00 PM

I shouuld add that I also took a high dose of probiotics a the same time as the PermaVite. I used a combination of VSL3 and Klaire labs. Took 500bill twice a day for a week then cut back. Also took antioxidants (ubiquinol, R-la, and others). I hope this is helpful.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 04, 2012
at 04:56 AM

Sorry ladies. I almost forgot that I had joined here... is there a way to get emails when comments are made to one's comments. Anyway GAPS is great Im sure. Have a friend who did it and helped her immensely. I was on Permative for 3 months. Retested IgG and is negative after 3 postive tests. I took the maximal recommended dose on the jar and per my doc - 3 serving per day. Hope this helps.

345c1755efe005edd162b770dc6fb821

(8767)

on June 02, 2012
at 09:45 PM

basically sulfur and is readily available in onions, garlic and cruciferous vegetables and in protein-containing foods, including nuts, seeds, milk and eggs......sounds like GAPS protocol

345c1755efe005edd162b770dc6fb821

(8767)

on June 02, 2012
at 09:41 PM

the MSM seems to me the only product I'm not sure what is, found this: http://en.wikipedia.org/wiki/Methylsulfonylmethane

4886d3390cb1de913ecc198e72cc072c

on June 02, 2012
at 04:34 PM

I have the same questions Kelly has - please post so others can read more. How long were you on PermaVite? When did you get the IgG test taken? Etc. I looked up the ingredients: L-Glutamine; N-Acetyl-D- Glucosamine (shrimp, crab, lobster); Slippery Elm (Ulmus rubra); (Bark) Powder;Stevia (Stevia rebaudiana) (Leaves) Extract Glandular Complex with Epithelial Growth Factor MSM (Methylsulfonylmethane) $30 on Amazon.

345c1755efe005edd162b770dc6fb821

(8767)

on June 02, 2012
at 12:48 PM

more info about permavite please, what did you take/amt, how long etc. (email me if you can, am very curious: [email protected])

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5 Answers

1
C2450eb7fa11b37473599caf93b461ef

on June 12, 2012
at 09:20 PM

My husband went off to an allergist/immunologist for chronic adult-onset asthma and sinus difficulties (didn't mention the IBS-type symptoms). He tested positively for 39 out of the 40 allergens introduced on the scratch test.

I'm not a doctor. Hell, I'm not even close to being a scientist in any shape or form. That being said, it seems to me that when you test with that many positives, something is going on other than specific allergies. Something has set off the immune system into a chronic cycle of response. I like what you said about circular reactions to chronic inflammation.

Of course, his doc wanted to put him on a steroid inhaler, a corticosteroid nasal spray, and come in for allergy shots once a week for the next three or more years.

1
42e692b555ac61880064d6ebdab23e9b

(10)

on June 12, 2012
at 04:48 PM

I had 173 IGG reactions from 238 foods tested. I found the diet to help but it was also malnourishing. Camel milk helps with IGGs as well as nutrition. It was very helpful. A gastaroligist could also prescribe an IGG blocker if he feels the matter is sever enough (but they often fail to understand the severity) I recon do the diet along with some camel milk.... Stop the diet after a month and continue with the milk, till you feel like dieting again..

I've been feeling pretty ok. In the range of normal. Might have a little bit of fatigue left in the system ( like if I exercise for an hour I'm tied for about 4-5 days, but if I 20 min cycling I'm fine or 30 min walking I'm fine..... So there is a bit of tiredness left, but I was really in a difficult condition at one point... I'm sure I'd be 100 percent ok in about a month and will be able to exercise for an hour, take 1-2 days rest and be ready again (which I would regard as completely normal)

1
4ef079c57d2140bba4dbf4e30240a645

on June 02, 2012
at 08:25 AM

I have used a product by Allergy Research Group called PermaVite to heal my leaky gut and it works! I also eat really healthy too of course.
Several others have also used Permavite.
Good stuff! I no longer test positive for IgG since I healed my gut.

4886d3390cb1de913ecc198e72cc072c

on June 02, 2012
at 04:34 PM

I have the same questions Kelly has - please post so others can read more. How long were you on PermaVite? When did you get the IgG test taken? Etc. I looked up the ingredients: L-Glutamine; N-Acetyl-D- Glucosamine (shrimp, crab, lobster); Slippery Elm (Ulmus rubra); (Bark) Powder;Stevia (Stevia rebaudiana) (Leaves) Extract Glandular Complex with Epithelial Growth Factor MSM (Methylsulfonylmethane) $30 on Amazon.

345c1755efe005edd162b770dc6fb821

(8767)

on June 02, 2012
at 09:41 PM

the MSM seems to me the only product I'm not sure what is, found this: http://en.wikipedia.org/wiki/Methylsulfonylmethane

345c1755efe005edd162b770dc6fb821

(8767)

on June 02, 2012
at 12:48 PM

more info about permavite please, what did you take/amt, how long etc. (email me if you can, am very curious: [email protected])

345c1755efe005edd162b770dc6fb821

(8767)

on June 02, 2012
at 09:45 PM

basically sulfur and is readily available in onions, garlic and cruciferous vegetables and in protein-containing foods, including nuts, seeds, milk and eggs......sounds like GAPS protocol

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 04, 2012
at 04:56 AM

Sorry ladies. I almost forgot that I had joined here... is there a way to get emails when comments are made to one's comments. Anyway GAPS is great Im sure. Have a friend who did it and helped her immensely. I was on Permative for 3 months. Retested IgG and is negative after 3 postive tests. I took the maximal recommended dose on the jar and per my doc - 3 serving per day. Hope this helps.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on June 04, 2012
at 05:00 PM

I shouuld add that I also took a high dose of probiotics a the same time as the PermaVite. I used a combination of VSL3 and Klaire labs. Took 500bill twice a day for a week then cut back. Also took antioxidants (ubiquinol, R-la, and others). I hope this is helpful.

4886d3390cb1de913ecc198e72cc072c

on June 05, 2012
at 04:08 AM

Thanks Crowlover for posting this info! I ordered PermaVite and anxious to try it.

91882203467f64f68f25f58f1caeee68

(1017)

on June 18, 2012
at 02:21 AM

Have any of you tried PermaVite with any success?

1
7b9b5de13a30c823dae64a971cb14add

on June 01, 2012
at 11:43 PM

for me, IgG tests successfully figured out my gluten/wheat intolerance (somehow i have positive gut biopsies even though my celiac genetic test was negative - no one can figure that out) which was then confirmed by biopsies through endoscopy and colonoscopy. tested it several times and oh yes, still sensitive after quite some time away and allegedly healing. now i'm curious to get more IgG tests done and see what they say...

0
D87d3ece76c09be3a1429d7bd5bf4807

on March 24, 2014
at 02:39 AM

@Kmmie can you tell me the name of the test you reference here:

He said there's a new blood test that can actually confirm whether the gut lining is still permeable

Thanks!

7b9b5de13a30c823dae64a971cb14add

(540)

on March 30, 2014
at 06:28 PM

yes please!

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