2

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Is there any serious, controlled study that shows that low serum cholesterol increase cardio or infectious risk

Answered on August 19, 2014
Created August 24, 2011 at 7:52 PM

are you aware of any serious, controlled study in which there is evidence showing that low or very low serum cholesterol will result in higher cardiovascular risk or infectious disease risk? I mean any study based on a group on a diet that results in low serum cholesterol where they perform significantly worse that a similar group on a diet that results in high or medium serum cholesterol ? The question arises because in a recent question that I made about why some modern paleo have very high total cholesterol another paleohacker showed population statistics in which the different levels of total cholesterol per country are regressed against cardiovascular and other risks. I do not consider that study important, because obviously if you compare, for instance (as they do) the rates of infectious diseases in Denmark or Norway with those in Angola or Malawi, there are many factors beyond diet that will be extremely important, such as access to antibiotics or modern medicine. So I am looking for some serious evidence of that sort, if there is any!

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on August 25, 2011
at 05:14 AM

A 2008 study published in the "Canadian Medical Association Journal" found a V-shaped association between LDL cholesterol levels and cancer in patients with Type 2 diabetes. In other words, both low and high levels of LDL cholesterol were associated with an increased cancer risk. Patients with LDL cholesterol levels below 2.80 mmol/L, or 108 mg/dL, and above 3.80mmol/L, or 146.6 mg/dL, had a greater risk of cancer within the study's five-year period.

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on August 25, 2011
at 04:59 AM

Diet studies can show a corelation between two numbers such as LDL and mortality rates. However they do not show causation. Most overlook that another variable might be responsible for both the LDL level and the mortality rate.

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on August 25, 2011
at 04:51 AM

THis helps a little but stops short of pointing out the real flaw in some of these studies which is that overall mortality increased under a low LDL diet. http://www.omen.com/corr.html

100fd85230060e754fc13394eee6d6f1

(18706)

on August 24, 2011
at 11:07 PM

There could be a lot of confounders, though. For example, TC isn't a very good predictor of cardiovascular risk, but triglycerides and HDL are. So if they found a diet that consistently lowers TC, it would likely have consistent effects on those, too.

100fd85230060e754fc13394eee6d6f1

(18706)

on August 24, 2011
at 11:04 PM

I see. That's an interesting question. :-)

Ac1e55cf06c2180f4008ff01953d10dd

(3524)

on August 24, 2011
at 10:47 PM

I slightly rephrased the question to make it more clear

Ac1e55cf06c2180f4008ff01953d10dd

(3524)

on August 24, 2011
at 10:43 PM

Ambimorph I am asking about a serious, group study that may have compared two groups, with one group being fed a diet that results in very low serum cholesterol and another that may have medium,or average serum cholesterol based on their diet. I am not asking about cholesterol intake but rather about serum cholesterol as a result of the diet (amount of fat, carbs, etc)

Ac1e55cf06c2180f4008ff01953d10dd

(3524)

on August 24, 2011
at 10:42 PM

Ambimorph I am asking about a seious, group study that may have compared two groups, with one group being fed a diet that results in very low serum cholesterol and another that may have medium,or average serum cholesterol based on their diet. I am not asking about cholesterol intake but rather about serum cholesterol as a result of the diet (amount of fat, carbs, etc)

100fd85230060e754fc13394eee6d6f1

(18706)

on August 24, 2011
at 10:20 PM

I'm a little confused. Your question starts out about consuming low amounts of dietary cholesterol, but the population statistics are about having low serum cholesterol. A clinical test could be made for the former, but not really for the latter. The latter would have to be observational, and, as you rightly pointed out, any links evinced would be associational not causal. So are you asking for a clinical study comparing dietary cholesterol and infectious disease rates, or about somehow inducing low serum cholesterol in the lab?

Ac1e55cf06c2180f4008ff01953d10dd

(3524)

on August 24, 2011
at 09:46 PM

I did not find any study showing adverse effects of a low cholesterol diet on cancer. I found this one who seems to show the opposite: medwire-news.md/46/92431/Oncology/… and then this one on the negative effects of statins, no on low cholesterol from diet medindia.net/news/

Ac1e55cf06c2180f4008ff01953d10dd

(3524)

on August 24, 2011
at 09:44 PM

I did not find any stuy showing adverse effects of a low cholesterol diet on cancer. I found this one who seems to show the opposite: http://www.medwire-news.md/46/92431/Oncology/Low-cholesterol_diet_may_aid_cancer_prevention.html and then this one on the negative effects of statins, no on low cholesterol from diet http://www.medindia.net/news/Low-Cholesterol-Levels-can-Increase-Cancer-Risk-Study-56042-1.htm

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on August 24, 2011
at 09:40 PM

i recently wrote about that .........and I will tell you that the biologic response of the cell to stress is to make more cholesterol not less......so when you have less around it stresses the cell and favors the epigenetic pathways that favor oncogenesis. Cholesterol is used to in stress for two main cellular functions. Making steroids for the brain's response and to stabilize mitochondrial membranes due to increased demand. There are thousands of articles on this.

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2 Answers

1
A0c5c2476efb58a1dd43c47a0e39e7d8

on November 17, 2011
at 10:18 AM

This Serious study showed that moderately elevated cholesterol (by current standards) may prove to be not only harmless but even beneficial. Does that help?

0
1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on August 24, 2011
at 08:08 PM

Cancer rates did increase with lower ldl. Should be easy to find.

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on August 25, 2011
at 04:59 AM

Diet studies can show a corelation between two numbers such as LDL and mortality rates. However they do not show causation. Most overlook that another variable might be responsible for both the LDL level and the mortality rate.

Ed71ab1c75c6a9bd217a599db0a3e117

(25472)

on August 24, 2011
at 09:40 PM

i recently wrote about that .........and I will tell you that the biologic response of the cell to stress is to make more cholesterol not less......so when you have less around it stresses the cell and favors the epigenetic pathways that favor oncogenesis. Cholesterol is used to in stress for two main cellular functions. Making steroids for the brain's response and to stabilize mitochondrial membranes due to increased demand. There are thousands of articles on this.

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on August 25, 2011
at 05:14 AM

A 2008 study published in the "Canadian Medical Association Journal" found a V-shaped association between LDL cholesterol levels and cancer in patients with Type 2 diabetes. In other words, both low and high levels of LDL cholesterol were associated with an increased cancer risk. Patients with LDL cholesterol levels below 2.80 mmol/L, or 108 mg/dL, and above 3.80mmol/L, or 146.6 mg/dL, had a greater risk of cancer within the study's five-year period.

Ac1e55cf06c2180f4008ff01953d10dd

(3524)

on August 24, 2011
at 09:46 PM

I did not find any study showing adverse effects of a low cholesterol diet on cancer. I found this one who seems to show the opposite: medwire-news.md/46/92431/Oncology/… and then this one on the negative effects of statins, no on low cholesterol from diet medindia.net/news/

Ac1e55cf06c2180f4008ff01953d10dd

(3524)

on August 24, 2011
at 09:44 PM

I did not find any stuy showing adverse effects of a low cholesterol diet on cancer. I found this one who seems to show the opposite: http://www.medwire-news.md/46/92431/Oncology/Low-cholesterol_diet_may_aid_cancer_prevention.html and then this one on the negative effects of statins, no on low cholesterol from diet http://www.medindia.net/news/Low-Cholesterol-Levels-can-Increase-Cancer-Risk-Study-56042-1.htm

1a98a40ba8ffdc5aa28d1324d01c6c9f

(20378)

on August 25, 2011
at 04:51 AM

THis helps a little but stops short of pointing out the real flaw in some of these studies which is that overall mortality increased under a low LDL diet. http://www.omen.com/corr.html

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