2

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excess serotonin & leaky stools

Commented on September 15, 2014
Created August 13, 2012 at 5:07 AM

I an beginning to think a large part of my ibs symptoms are directly due to dysregulation of serotonin in my system, gut and or brain.

The evidence is out there that excess serotonin is present in ibs-d cases. Does anyone have experience with this concept?

Are there ways of flushing serotonin from the system quickly to see if symptoms improve?

I know this seems to fly in the face of serotonin being the happy molecule, but when I get leaky stool I also get depression symptoms, and I can't really figure out what causes them, though I've been food experimenting for years. (I don't have the money to get more tests so confirming ibd isn't an option, unless someone knows a pro bono gastroenterologist)

F7610110b12b2e1ebd9f5fba1b1f217f

(0)

on September 15, 2014
at 02:09 PM

Comment on my post: the last sentence talks about kundalini. Please know that I in no way promote the teachings of this. Was added by accident. Thanks.

F7610110b12b2e1ebd9f5fba1b1f217f

(0)

on September 15, 2014
at 01:56 PM

There can be elevated serotonine due to bacterial overgrowth. I had elevated serotonine and after coffee enema with ground cloves the next day pieces of tape worm turned up. I might have baterial overgrowth as well. Here are other reasons “Another effect of too much ammonia includes an increase in the turnover of serotonin in the brain. Studies show there might be a disturbance in the tryptophan-serotonin metabolism in people with ADD, for the more severe the hyperactivity of ADD, the higher the plasma free tryptophan (serotonin) level. Free serotonin in the plasma can be caused by allergies, low magnesium, toxins from the gut, or free unsaturated fatty acids. Stress, including that caused by low blood sugar, releases fatty acids into the blood. Magnesium stabilizes platelets and mast cells reducing their release of serotonin into the plasma. Yet another form of attention deficit hyperactivity shows excessive dopaminergic activity plus norepinephrine overactivity. Excessive dopaminergic and norepinephrine overactivity can occur when the liver's sulfation pathway is weakened by intestinal inflammation and mercury poisoning. We have to consider that kundalini with its hyperactivated HPA axis and consequent immune suppression may increase intestinal inflammation.”

 

4ef079c57d2140bba4dbf4e30240a645

(4413)

on August 14, 2012
at 07:57 AM

Good to know. I hope you can get the script. You have health insurance but no assess to a doctor? Im sorry about that. Oh - a "useful" doctor. Keep trying. Hopefully you will find a doc who agrees to a TRIAL of Vsl for your chronic diarrhea. It seems reasonable. Hang in.

05055dcbf12c81f1cce777ec365870af

(1791)

on August 14, 2012
at 12:47 AM

Well the dbl strength vsl is scrip only so one could get it via insurance. I didn't get a naltrex scrip, I made my own buying the tablets from India. I am one of many with no access to useful doctors.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on August 13, 2012
at 09:42 PM

I didn't know that ins. would every pay for VSL, unless you had part of your colon removed. Dang, good luck with that. I hope that you can get an Rx. Can you ask the doctor who wrote you the Naltrexone script to write one for VSL. For a trial of VSL. If they will, ask for a lot. Like 4 packets a day (although you may only need two per day.). I hope you win the lottery - truly because its quite possible that just the VSL, in the right dose 2-4 packets per day, would help you. Hang in.

05055dcbf12c81f1cce777ec365870af

(1791)

on August 13, 2012
at 02:36 PM

Jamie, any specific brands or links?

05055dcbf12c81f1cce777ec365870af

(1791)

on August 13, 2012
at 02:34 PM

Korion, dude what's wrong with being too happy? I'm not happy enough. Please email me at dariussohei0 at gmail

05055dcbf12c81f1cce777ec365870af

(1791)

on August 13, 2012
at 02:32 PM

Hey crow, ldn does something... But its so subtle, I can't say forsure it works for me. High dose vsl is way too expensive unless I get a prescription. Any docs willing to help me get a scrip?

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on August 13, 2012
at 01:00 PM

As I mentioned to Korion I beleive, the serenic receptor (5ht1a) does downregulate the rest of the serotonin system. Lotus flower and root, albizzia flowers and bark, the soursop fruit are all proven to have serenic effects. Those are mild herbs and foods and if you wanted to play with downregulating your serotonin system, that would be where Id personally point you.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on August 13, 2012
at 12:57 PM

I would advise against attempts to lower your overall whole body level of all types of serotonin. Its used for too much (sleep, mood, digestion, memory etc).

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on August 13, 2012
at 12:55 PM

BTW gut motility is regulared by serotonin for sure. I doubt that anyones gut problems are due to a general excess of the NT though, more like nerve issues, or specific regulation issues. A specific antagonist, like the 5ht3 ones, from a doctor can help some with IBS. But then again, thats not nessasarily the underlying cause. Even if a 5ht3 helps, it could be nerve damage, or dysregulation of specific nervous system channels thats at fault. Serotonin being the motility regulator is also why people get sore stomachs after taking 5-htp.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on August 13, 2012
at 12:51 PM

^ serotonin antagonists....like what? Do you mean 5-HT3 antagonists?

B0fe7b5a9a197cd293978150cbd9055f

(8938)

on August 13, 2012
at 11:49 AM

Peat talks about this a lot, and my digestion issues seem directly related to serotonin since they disappear when i use serotonin antagonists. I dont take those any ore because they tend to make me too happy, which doesnt work that well in a society :P I recently asked about serotonin and why its called the happy hormone since autists are known to be high in serotonin. And they are not happy.

Bb3d1772b28c02da2426e40dfcb533f5

(5381)

on August 13, 2012
at 10:42 AM

IDK, but digestive distress depresses me, regardless of neurochemicals. Have you tried a GAPS, or fodmaps diet? Often impaired motility is cause by bacterial toxins (not always), according to dr pimental, these toxins can damage the nerves that control motility.

4ef079c57d2140bba4dbf4e30240a645

(4413)

on August 13, 2012
at 06:52 AM

I like your question.. even though the idea of "flushing serotonin" really concerns me. I hope you get some answers. Didn't you look into low dose Naltrexone? Also have your tried high doses of probiotics, like VSL3?

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