I had been plagued by this for about the last 20 years. Was able to manage it with certain diet compositions, but I knew there was some nutrient missing. Tried magnesium, zinc, chromium etc. with no perceptible difference. I then decided to try taking a biotin supplement (500mcg d-biotin once a day), and lo and behold, it completely corrected it for me. I don't know if it's because my gut bacteria aren't producing it or I have some failure of biotinidase that is causing it to be insufficiently recycled, but whatever the reason, this supplement has completely corrected it.
I've seen some studies where it's used to help diabetics, so I'd say that if you're having trouble managing your blood glucose in some way or another, you might want to give it a try.
Interestingly, I used to be unable to take vitamin k-2 because even 45mcg for a few days would cause a day of blood sugar episodes until my levels dropped again. I can now take 360mcg a day with zero issues. They're both involved with carboxylation, but I corresponded with a K2 researcher and he wasn't sure why that would occur but said they don't interact at all. No idea, but I'm psyched about being able to carboxylate osteocalcin and MGP.
Lastly, this supplement is most often used by women trying to grow healthier hair and nails, and I definitely noticed that what hair I have grows faster, as do my fingernails. My skin is also much less dry, since it's involved in the processing of EFAs and other fatty acids.
It comes in large doses like 5 and 10mg, but I don't really see the point of taking that much, though I don't know if it'd actually be harmful. I've seen some reports of people getting acne from it, but I think that's simply the result of them finally having adequate sebum production, and because they're deficient in vitamin A and/or zinc, it exacerbates the situation. I noticed no such reaction.
asked byTravis_Culp (39831)
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on May 11, 2013
at 02:48 PM
(I'm going to answer just because this is too big for a comment)
First off, let me get out of the way that this is a very interesting and potentially useful hack. Thanks for sharing it. Second off, let me add the disclaimer that I do not have reactive hypoglycemia personally, and that I am not a doctor (as i'm sure you are aware) so take what I say with a grain of salt (which you should do anyways).
From what I understand about reactive hypoglycemia, is that it occurs when you ingest carbohydrate (or protein without sufficient carbohydrate to balance the insulin rush) and your pancreas overshoots the amount of insulin necessary to transport the glucose to your cells. Then you rebound and end up with low blood sugar, despite having ingested carbs. So, what this means is, if you can circumvent the insulin-carb-transport pathway, and instead take advantage of "non-insulin-dependent glucose-uptake," then your problem may be treated.
One way to take advantage of NIDGC is to stimulate your muscle fibers, and particularly your type II (fast twitch) muscle fibers, and, to a somewhat lesser extent, your type I (slow twitch) fibers as well. These will have the affect of increasing your muscular insulin sensitivity, and increasing insulin sensitivity means requiring LESS insulin to get the same job done (transport x amount of carbs to your cells). So, I invite you to consider the therapeutic efficacy of HIIT/strength/weight/bodyweight training.
Another way to take advantage of NIDGC is to eat your carbs in the beloved "post workout window." This is the diminishing window of time when your muscle cells are most insulin sensitive, and it begins the moment you stop working out and declines there after (although remains elevated among baseline in comparison to "average" people). So, I would suggest that if you do take up my suggestion on point one, to try to consume the majority of your carbs in/around your workout window. Generally as close to finishing weight training as possible. A small pre workout carb meal is fine and perhaps needed, and then 2 larger carb meals post workout should do the trick (one immediately...like fruit) and then another 1-3 hours later (like meat/starch).
Finally, the third way is the use of alpha lipoic acid or r-alpha lipoic acid. This is a "universal antixidant" (both water and fat soluble) and is crucial for blood glucose transport. WHat this nutrient does is fascilitate glucose transport without the need for additional insulin, so it affectively lowers your insulin load. I have been taking this for the past 7 years with my post workout meal, and I do feel that it aids in glycogen replenishment (however, there is the risk for bias and placebo). However, don't take my word for it, I suggest you read up on r-ala and experiment with it yourself.
I really do think all of these will work synergistically to amplify the therapeutic affect, but of course one is better than none, in my opinion. I would invite you to at least consider these options as well.
Thanks for the excellent hack, as usual.
on May 23, 2013
at 04:10 AM
I have reactive hypoglycemia, yes. Unforunately. I am currently working on getting off of Metformin ER, as I feel it may be contributing to the hypoglycemic episodes. I am on week 3 of eating Paleo. Hoping to correct it with my diet, so the info you've given is great! Any other feedback would be awesome.